{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:49:04Z","timestamp":1777909744004,"version":"3.51.4"},"reference-count":121,"publisher":"SAGE Publications","issue":"2-3","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Microfibrils are macromolecular aggregates located in the extracellular matrix of both elastic and nonelastic tissues that have essential functions in formation of elastic fibers and control of signaling through the transforming growth factor beta (TGF\u03b2) family of cytokines. Elevation of systemic TGF\u03b2 and chronic activation of TGF\u03b2 signal transduction are associated with diseases caused by mutations in microfibril-associated genes, including\n                    <jats:italic toggle=\"yes\">FBN1<\/jats:italic>\n                    . A role for microfibrils in glaucoma is suggested by identification of risk alleles in\n                    <jats:italic toggle=\"yes\">LOXL1<\/jats:italic>\n                    for exfoliation glaucoma and mutations in\n                    <jats:italic toggle=\"yes\">LTBP2<\/jats:italic>\n                    for primary congenital glaucoma, both of which are microfibril-associated genes. Recent identification of a mutation in another microfibril-associated gene,\n                    <jats:italic toggle=\"yes\">ADAMTS10<\/jats:italic>\n                    , in a dog model of primary open-angle glaucoma led us to form the microfibril hypothesis of glaucoma, which in general states that defective microfibrils may be an underlying cause of glaucoma. Microfibril defects could contribute to glaucoma through alterations in biomechanical properties of tissue and\/or through effects on signaling through TGF\u03b2, which is well established to be elevated in the aqueous humor of glaucoma patients. Recent work has shown that diseases caused by microfibril defects are associated with increased concentrations of TGF\u03b2 protein and chronic activation of TGF\u03b2-mediated signal transduction. In analogy with other microfibril-related diseases, defective microfibrils could provide a mechanism for the elevation of TGF\u03b22 in glaucomatous aqueous humor. If glaucoma shares mechanisms with other diseases caused by defective microfibrils, such as Marfan syndrome, therapeutic interventions to inhibit chronic activation of TGF\u03b2 signaling used in those diseases may be applied to glaucoma.\n                  <\/jats:p>","DOI":"10.1089\/jop.2013.0184","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T17:11:05Z","timestamp":1392225065000},"page":"170-180","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["The Microfibril Hypothesis of Glaucoma: Implications for Treatment of Elevated Intraocular Pressure"],"prefix":"10.1177","volume":"30","author":[{"given":"John","family":"Kuchtey","sequence":"first","affiliation":[{"name":"Vanderbilt University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel W.","family":"Kuchtey","sequence":"additional","affiliation":[{"name":"Vanderbilt University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,2,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001306"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1146554"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp338"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.03.017"},{"key":"e_1_3_3_6_2","first-page":"111","article-title":"Glaucoma in the Marfan syndrome","volume":"90","author":"Izquierdo N.J.","year":"1992","unstructured":"Izquierdo N.J., , Traboulsi E.I., , Enger C., , and Maumenee I.H. Glaucoma in the Marfan syndrome. Trans. Am. Ophthalmol. Soc., 90:111\u2013117; discussion 118\u2013122, 1992.","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/520125"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(05)70012-7"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2009.05.005"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-009-0822-x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2011.12.008"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvs089"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(54)90008-2"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(58)90049-2"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091420205"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.40.2.366"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2010.03.009"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.103.6.2499"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20101320"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033560"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511599200"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-11619"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200608167"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.073437"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2006.12.006"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23385"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2012.01.006"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2010.08.002"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200611044"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.841981"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1116"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200422715"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-12-0874"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002425"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.05.012"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.199"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000488"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22165"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.45"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.029819"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e08-08-0830"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110723"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420641"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2840"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.40.5.257"},{"key":"e_1_3_3_46_2","first-page":"144","article-title":"Light and electron microscopy of the presumed elastic components of the trabeculae and scleral spur of the human eye","volume":"3","author":"Iwamoto T.","year":"1964","unstructured":"Iwamoto T. Light and electron microscopy of the presumed elastic components of the trabeculae and scleral spur of the human eye. Invest. Ophthalmol., 3:144\u2013156, 1964.","journal-title":"Invest. Ophthalmol."},{"key":"e_1_3_3_47_2","first-page":"574","article-title":"The fine structure of the cribriform meshwork in normal and glaucomatous eyes as seen in tangential sections","volume":"21","author":"Rohen J.W.","year":"1981","unstructured":"Rohen J.W., , Futa R., , and Lutjen-Drecoll E. The fine structure of the cribriform meshwork in normal and glaucomatous eyes as seen in tangential sections. Invest. Ophthalmol. Vis. Sci., 21:574\u2013585, 1981.","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-1002"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713688908997400"},{"key":"e_1_3_3_50_2","first-page":"563","article-title":"Ultrahistochemical studies on tangential sections of the trabecular meshwork in normal and glaucomatous eyes","volume":"21","author":"Lutjen-Drecoll E.","year":"1981","unstructured":"Lutjen-Drecoll E., , Futa R., , and Rohen J.W. Ultrahistochemical studies on tangential sections of the trabecular meshwork in normal and glaucomatous eyes. Invest. Ophthalmol. Vis. Sci., 21:563\u2013573, 1981.","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_3_51_2","first-page":"1068","article-title":"Distribution of myocilin and extracellular matrix components in the juxtacanalicular tissue of human eyes","volume":"43","author":"Ueda J.","year":"2002","unstructured":"Ueda J., , Wentz-Hunter K., , and Yue B.Y. Distribution of myocilin and extracellular matrix components in the juxtacanalicular tissue of human eyes. Invest. Ophthalmol. Vis. Sci., 43:1068\u20131076, 2002.","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5620"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.11.025"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2008"},{"key":"e_1_3_3_55_2","first-page":"486","article-title":"Localization of elastin in the normal and glaucomatous human trabecular meshwork","volume":"35","author":"Umihira J.","year":"1994","unstructured":"Umihira J., , Nagata S., , Nohara M., , Hanai T., , Usuda N., , and Segawa K. Localization of elastin in the normal and glaucomatous human trabecular meshwork. Invest. Ophthalmol. Vis. Sci., 35:486\u2013494, 1994.","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1995.01100010105028"},{"key":"e_1_3_3_57_2","first-page":"970","article-title":"Increased extracellular deposition of fibrillin-containing fibrils in pseudoexfoliation syndrome","volume":"38","author":"Schlotzer-Schrehardt U.","year":"1997","unstructured":"Schlotzer-Schrehardt U., , von der Mark K., , Sakai L.Y., , and Naumann G.O. Increased extracellular deposition of fibrillin-containing fibrils in pseudoexfoliation syndrome. Invest Ophthalmol Vis Sci, 38:970\u2013984, 1997.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00496153"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(86)90004-7"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1993.1085"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.157776"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ijg.0000131757.63542.24"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2011.03.011"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.17.7.076026"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90405-7"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3118"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1297"},{"key":"e_1_3_3_68_2","first-page":"265","article-title":"Variations in LOXL1 associated with exfoliation glaucoma do not affect amine oxidase activity","volume":"18","author":"Kim S.","year":"2012","unstructured":"Kim S., , and Kim Y. Variations in LOXL1 associated with exfoliation glaucoma do not affect amine oxidase activity. Mol. Vis., 18:265\u2013270, 2012.","journal-title":"Mol. Vis."},{"key":"e_1_3_3_69_2","first-page":"333","article-title":"Contribution of the latent transforming growth factor-beta binding protein 2 gene to etiology of primary open angle glaucoma and pseudoexfoliation syndrome","volume":"19","author":"Jelodari-Mamaghani S.","year":"2013","unstructured":"Jelodari-Mamaghani S., , Haji-Seyed-Javadi R., , Suri F., et al. Contribution of the latent transforming growth factor-beta binding protein 2 gene to etiology of primary open angle glaucoma and pseudoexfoliation syndrome. Mol. Vis., 19:333\u2013347, 2013.","journal-title":"Mol. Vis."},{"key":"e_1_3_3_70_2","first-page":"2424","article-title":"Spontaneous mutations In LTBP2 are associated with congenital glaucoma in cats","volume":"52","author":"Kuehn M.H.","year":"2011","unstructured":"Kuehn M.H., , McLellan G.J., , Pfleging A., , Snella E.M., , and Ellinwood N.M. Spontaneous mutations In LTBP2 are associated with congenital glaucoma in cats. Invest. Ophthalmol. Vis. Sci., 52:2424, 2011.","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601768"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10796"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409036200"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.231571"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1086\/425231"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.1.34"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20289"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199007193230303"},{"key":"e_1_3_3_79_2","first-page":"1135","article-title":"Clinical manifestations of inherited glaucoma in the beagle","volume":"16","author":"Gelatt K.N.","year":"1977","unstructured":"Gelatt K.N., , Peiffer R.L.Jr., , Gwin R.M., , Gum G.G., , and Williams L.W. Clinical manifestations of inherited glaucoma in the beagle. Invest. Ophthalmol. Vis. Sci., 16:1135\u20131142, 1977.","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.01.028"},{"key":"e_1_3_3_81_2","first-page":"1757","article-title":"Cornea in Marfan disease: orbscan and in vivo confocal microscopy analysis","volume":"43","author":"Sultan G.","year":"2002","unstructured":"Sultan G., , Baudouin C., , Auzerie O., , De Saint Jean M., , Goldschild M., , and Pisella P.J. Cornea in Marfan disease: orbscan and in vivo confocal microscopy analysis. Invest. Ophthalmol. Vis. Sci., 43:1757\u20131764, 2002.","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.6.714"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181ca7708"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.07.058"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1994.1158"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004170000241"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-5155(01)00523-8"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004170000252"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1006\/exer.2001.1084"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:INTE.0000018524.48581.79"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1159\/000083019"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2006.20.3.162"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-011-1274-7"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0796"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1060"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3380"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4567"},{"key":"e_1_3_3_98_2","first-page":"684","article-title":"Altered expression of transforming growth factor beta 1 and matrix metalloproteinase-9 results in elevated intraocular pressure in mice","volume":"19","author":"Robertson J.V.","year":"2013","unstructured":"Robertson J.V., , Siwakoti A., , and West-Mays J.A. Altered expression of transforming growth factor beta 1 and matrix metalloproteinase-9 results in elevated intraocular pressure in mice. Mol. Vis., 19:684\u2013695, 2013.","journal-title":"Mol. Vis."},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2005.10.011"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.01.013"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124287"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1536"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31337"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199805000-00012"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.06.024"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq409"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1192152"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2013.830104"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000182521.44440.c5"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.6.789"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41709"},{"key":"e_1_3_3_112_2","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-11-3"},{"key":"e_1_3_3_113_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890802043924"},{"key":"e_1_3_3_114_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200008000-00005"},{"key":"e_1_3_3_115_2","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.23.2.133.5473"},{"key":"e_1_3_3_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2004.11.012"},{"key":"e_1_3_3_117_2","doi-asserted-by":"publisher","DOI":"10.1006\/exer.2000.0866"},{"key":"e_1_3_3_118_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S15971"},{"key":"e_1_3_3_119_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1192149"},{"key":"e_1_3_3_120_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2008.042002"},{"key":"e_1_3_3_121_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066082"},{"key":"e_1_3_3_122_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11427"}],"container-title":["Journal of Ocular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jop.2013.0184","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jop.2013.0184","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jop.2013.0184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:39:09Z","timestamp":1777646349000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jop.2013.0184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,12]]},"references-count":121,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2014,3,1]]}},"alternative-id":["10.1089\/jop.2013.0184"],"URL":"https:\/\/doi.org\/10.1089\/jop.2013.0184","relation":{},"ISSN":["1080-7683","1557-7732"],"issn-type":[{"value":"1080-7683","type":"print"},{"value":"1557-7732","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,12]]}}}