{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:22:37Z","timestamp":1778628157835,"version":"3.51.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"2-3","license":[{"start":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T00:00:00Z","timestamp":1390435200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To determine whether interleukin-20 receptors (IL-20R) are expressed in trabecular meshwork cells and the effect of a T104M mutation in IL-20R2 on downstream cellular functions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Evaluation of signal transducer and activator of transcription (STAT)3 phosphorylation and generic matrix metalloproteinase (MMP) activity in primary open angle glaucoma (POAG) dermal fibroblasts (pHDF) with the T104M IL-20R2 mutation were compared with normal human dermal fibroblasts (HDF). Expression of IL-20R1 and IL-20R2 in human trabecular meshwork (HTM) cells was determined by immunohistochemistry and western immunoblotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A T104M mutation in IL20-R2 was identified in a large POAG family in which the\n                      <jats:italic toggle=\"yes\">GLC1C<\/jats:italic>\n                      locus was originally mapped. pHDFs harboring this mutation had significantly increased phosphorylated STAT3 (pSTAT3) activity compared with normal HDFs. However, stimulation with either IL-19 or IL-20 for 15\u2009min resulted in significantly decreased levels of pSTAT3 in pHDFs compared with controls. Generic MMP activity was significantly decreased in pHDFs compared with controls after stimulation with IL-20 for 24\u2009h. Both IL-20R1 and IL-20R2 receptors were expressed in HTM cells by western immunoblot and immunofluorescence, and they appeared to be up-regulated in response to cytokine treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A T104M mutation in IL-20R2 significantly impacts the function of this receptor as shown by decreased pSTAT3 levels and generic MMP activity. Reduced MMP activity may affect the ability of glaucoma patients to alter outflow resistance in response to elevated intraocular pressure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2013.0187","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T11:12:20Z","timestamp":1390475540000},"page":"267-276","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Interleukin-20 Receptor Expression in the Trabecular Meshwork and Its Implication in Glaucoma"],"prefix":"10.1177","volume":"30","author":[{"given":"Kate E.","family":"Keller","sequence":"first","affiliation":[{"name":"Oregon Health & Sciences University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Feng","family":"Yang","sequence":"additional","affiliation":[{"name":"Oregon Health & Sciences University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying Ying","family":"Sun","sequence":"additional","affiliation":[{"name":"Oregon Health & Sciences University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee","family":"Sykes","sequence":"additional","affiliation":[{"name":"Oregon Health & Sciences University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie Donna","family":"Gaudette","sequence":"additional","affiliation":[{"name":"Oregon Health & Sciences University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Samples","sequence":"additional","affiliation":[{"name":"Oregon Health & Sciences University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ted S.","family":"Acott","sequence":"additional","affiliation":[{"name":"Oregon Health & Sciences University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary K.","family":"Wirtz","sequence":"additional","affiliation":[{"name":"Oregon Health & Sciences University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.06.004"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61423-7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2005.11.001"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6339"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000978"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr120"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq144"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.824"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.661"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/338709"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.020024"},{"key":"e_1_3_3_13_2","first-page":"264","article-title":"Single nucleotide polymorphism of MYOC affected the severity of primary open angle glaucoma","volume":"6","author":"Zhou X.M.","year":"2013","unstructured":"Zhou X.M., , Yin Y., , Fan N., et al. Single nucleotide polymorphism of MYOC affected the severity of primary open angle glaucoma. Int. J. Ophthalmol., 6:264\u2013268, 2013.","journal-title":"Int. J. Ophthalmol."},{"key":"e_1_3_3_14_2","first-page":"3064","article-title":"Compound heterozygote myocilin mutations in a pedigree with high prevalence of primary open-angle glaucoma","volume":"18","author":"Young T.K.","year":"2012","unstructured":"Young T.K., , Souzeau E., , Liu L., et al. Compound heterozygote myocilin mutations in a pedigree with high prevalence of primary open-angle glaucoma. Mol. Vis., 18:3064\u20133069, 2012.","journal-title":"Mol. Vis."},{"key":"e_1_3_3_15_2","first-page":"3243","article-title":"Myocilin mutations among POAG patients from two populations of Tamil Nadu, South India, a comparative analysis","volume":"17","author":"Rose R.","year":"2011","unstructured":"Rose R., , Balakrishnan A., , Muthusamy K., , Arumugam P., , Shanmugam S., , and Gopalswamy J. Myocilin mutations among POAG patients from two populations of Tamil Nadu, South India, a comparative analysis. Mol. Vis., 17:3243\u20133253, 2011.","journal-title":"Mol. Vis."},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-7938"},{"key":"e_1_3_3_17_2","first-page":"352","article-title":"Genes upregulated in the human trabecular meshwork in response to elevated intraocular pressure","volume":"41","author":"Gonzalez P.","year":"2000","unstructured":"Gonzalez P., , Epstein D.L., , and Borras T. Genes upregulated in the human trabecular meshwork in response to elevated intraocular pressure. Invest. Ophthalmol. Vis. Sci., 41:352\u2013361, 2000.","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5317"},{"key":"e_1_3_3_19_2","first-page":"534","article-title":"Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells","volume":"15","author":"Luna C.","year":"2009","unstructured":"Luna C., , Li G., , Liton P.B., , Epstein D.L., , and Gonzalez P. Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells. Mol. Vis., 15:534\u2013544, 2009.","journal-title":"Mol. Vis."},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)01138-2"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1994.1158"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004170000241"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5216"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8434"},{"key":"e_1_3_3_25_2","first-page":"431","article-title":"Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes","volume":"18","author":"Chua J.","year":"2012","unstructured":"Chua J., , Vania M., , Cheung C.M., et al. Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes. Mol. Vis., 18:431\u2013438, 2012.","journal-title":"Mol. Vis."},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12274"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767050500440986"},{"key":"e_1_3_3_28_2","first-page":"647","article-title":"Potent antitumor effect elicited by RGD-mda-7, an mda-7\/IL-24 mutant, via targeting the integrin receptor of tumor cells","volume":"26","author":"Zhang B.F.","unstructured":"Zhang B.F., , Liu J.J., , Pei D.S., et al. Potent antitumor effect elicited by RGD-mda-7, an mda-7\/IL-24 mutant, via targeting the integrin receptor of tumor cells. Cancer Biother. Radiopharm., 26:647\u2013655.","journal-title":"Cancer Biother. Radiopharm."},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00187-8"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.7.3545"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi0354583"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205114200"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.24.14400"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301330"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363714"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208602200"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102843"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.11.023"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr572"},{"key":"e_1_3_3_40_2","first-page":"296","article-title":"Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q","volume":"60","author":"Wirtz M.K.","year":"1997","unstructured":"Wirtz M.K., , Samples J.R., , Kramer P.L., et al. Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q. Am. J. Hum. Genet., 60:296\u2013304, 1997.","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.64.4.232"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1974.tb00367.x"},{"key":"e_1_3_3_43_2","first-page":"1043","article-title":"Human trabecular cells. I. Establishment in tissue culture and growth characteristics","volume":"18","author":"Polansky J.R.","year":"1979","unstructured":"Polansky J.R., , Weinreb R.N., , Baxter J.D., , and Alvarado J. Human trabecular cells. I. Establishment in tissue culture and growth characteristics. Invest. Ophthalmol. Vis. Sci., 18:1043\u20131049, 1979.","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1977.03280160022005"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713689508998409"},{"key":"e_1_3_3_46_2","first-page":"1639","article-title":"Ankyrin repeat and suppressor of cytokine signaling box containing protein-10 is associated with ubiquitin-mediated degradation pathways in trabecular meshwork cells","volume":"19","author":"Keller K.E.","year":"2013","unstructured":"Keller K.E., , Yang Y.F., , Sun Y.Y., , Sykes R., , Acott T.S., , and Wirtz M.K. Ankyrin repeat and suppressor of cytokine signaling box containing protein-10 is associated with ubiquitin-mediated degradation pathways in trabecular meshwork cells. Mol. Vis., 19:1639\u20131655, 2013.","journal-title":"Mol. Vis."},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1666"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048523"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/j..2004.00182.x"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117551109"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1593\/neo.06820"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.45"},{"key":"e_1_3_3_53_2","first-page":"1505","article-title":"Effects of mechanical stretching on trabecular matrix metalloproteinases","volume":"42","author":"Bradley J.M.","year":"2001","unstructured":"Bradley J.M., , Kelley M.J., , Zhu X., , Anderssohn A.M., , Alexander J.P., , and Acott T.S. Effects of mechanical stretching on trabecular matrix metalloproteinases. Invest. Ophthalmol. Vis. Sci., 42:1505\u20131513, 2001.","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_3_54_2","first-page":"2649","article-title":"Effect of matrix metalloproteinases activity on outflow in perfused human organ culture","volume":"39","author":"Bradley J.M.","year":"1998","unstructured":"Bradley J.M., , Vranka J., , Colvis C.M., et al. Effect of matrix metalloproteinases activity on outflow in perfused human organ culture. Invest. Ophthalmol. Vis. Sci., 39:2649\u20132658, 1998.","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Journal of Ocular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jop.2013.0187","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jop.2013.0187","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jop.2013.0187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:39:10Z","timestamp":1777646350000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jop.2013.0187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,23]]},"references-count":53,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2014,3,1]]}},"alternative-id":["10.1089\/jop.2013.0187"],"URL":"https:\/\/doi.org\/10.1089\/jop.2013.0187","relation":{},"ISSN":["1080-7683","1557-7732"],"issn-type":[{"value":"1080-7683","type":"print"},{"value":"1557-7732","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,23]]}}}