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This OHT is due to increased aqueous humor (AH) outflow resistance in the trabecular meshwork (TM) caused by GC-mediated changes in TM structure and function. GCs may also play a role in the development of primary open-angle glaucoma (POAG). Elevated cortisol levels in the AH or enhanced GC sensitivity may be one of the reasons for elevated intraocular pressure in POAG patients. The GC OHT responder population is at greater risk of developing POAG compared with non-responders. We recently have gained insight into the molecular mechanisms responsible for this differential GC responsiveness, which is attributed to differences in GC receptor isoform expression in the TM. This article summarizes current knowledge on alternative GC receptor splicing to generate GC receptor alpha (GR\u03b1) and GR\u03b2 and their roles in the regulation of GC responsiveness in normal and glaucoma TM.<\/jats:p>","DOI":"10.1089\/jop.2013.0239","type":"journal-article","created":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T16:04:09Z","timestamp":1391789049000},"page":"121-127","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Role of the Alternatively Spliced Glucocorticoid Receptor Isoform GR\u03b2 in Steroid Responsiveness and Glaucoma"],"prefix":"10.1177","volume":"30","author":[{"given":"Ankur","family":"Jain","sequence":"first","affiliation":[{"name":"University of North Texas Health Science Center"},{"name":"University of North Texas Health Science Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Wordinger","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center"},{"name":"University of North Texas Health Science Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Yorio","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center"},{"name":"University of North Texas Health Science Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbot F.","family":"Clark","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center"},{"name":"University of North Texas Health Science Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,2,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.10.004"},{"key":"e_1_3_3_3_2","first-page":"478","article-title":"Dexamethasone-induced ocular hypertension in perfusion-cultured human eyes","volume":"36","author":"Clark A.F.","year":"1995","unstructured":"Clark A.F., , Wilson K., , de Kater A.W., , Allingham R.R., , and McCartney M.D. Dexamethasone-induced ocular hypertension in perfusion-cultured human eyes. 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