{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:49:16Z","timestamp":1777909756786,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T00:00:00Z","timestamp":1411344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2015,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate corneal and conjunctival sensitivity changes following intravitreal ranibizumab (IVR) injection in eyes with diabetic retinopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Forty-six eyes of 46 patients with diabetic macular edema who underwent intravitreal injection of ranibizumab were included in this prospective study. Fifty eyes of 50 type 2 diabetes mellitus patients served as controls. Each participant underwent a complete ophthalmological examination. Fundus florescein angiography and optical coherence tomography were performed to assess the posterior segment details. IVR (0.5\u2009mg\/0.05\u2009mL) was injected from the lower temporal quadrant. Corneal and conjunctival sensitivities were measured using the Cochet-Bonnet esthesiometer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Corneal sensitivity (CS) increased significantly on the first day in temporal and nasal corneas in treated eyes (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.005 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.000, respectively). At week one the increase continued and the difference was significant in central, temporal, and nasal corneas (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.000). In fellow eyes, CS increased significantly only in nasal cornea (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.004). Only nasal conjunctival sensitivity increased significantly both in treated and fellow eyes at week one (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.000 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.005, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>IVR may have a potential to increase corneal and conjunctival sensitivities in diabetic retinopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2014.0017","type":"journal-article","created":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T15:39:35Z","timestamp":1411400375000},"page":"37-42","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Corneal and Conjunctival Sensitivity Changes Following Intravitreal Ranibizumab Injection in Diabetic Retinopathy"],"prefix":"10.1177","volume":"31","author":[{"given":"Nurg\u00fcl","family":"\u00d6rnek","sequence":"first","affiliation":[{"name":"K\u0131r\u0131kkale University School of Medicine","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kemal","family":"\u00d6rnek","sequence":"additional","affiliation":[{"name":"K\u0131r\u0131kkale University School of Medicine","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130nci Elif","family":"Erbah\u00e7eci","sequence":"additional","affiliation":[{"name":"K\u0131r\u0131kkale University School of Medicine","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,9,22]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903360405"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)00995-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004397-199838020-00004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/157339912800840479"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1396"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0938.2012.00743.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-225185"},{"key":"e_1_3_2_9_2","first-page":"573","article-title":"VEGF as an angiogenic, neurotrophic, and neuroprotective factor","volume":"59","author":"Namieci'nska M.","year":"2005","unstructured":"Namieci'nska M., , Marciniak K., , and Nowak J.Z. VEGF as an angiogenic, neurotrophic, and neuroprotective factor. Postepy Hig. Med. Dosw., 59:573\u2013583, 2005.","journal-title":"Postepy Hig. Med. Dosw."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.08.014"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1129"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.12.001"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-14-05731.1999"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.061237"},{"key":"e_1_3_2_15_2","first-page":"1083","article-title":"VEGF-induced neuroprotection, neurogenesis and angiogenesis after focal cerebral ischemia","volume":"107","author":"Sun Y.","year":"2001","unstructured":"Sun Y., , Jin K., , Xie L., , Childs J., , Mao X.O., , Logvinova A., , and Greenberg D.A. VEGF-induced neuroprotection, neurogenesis and angiogenesis after focal cerebral ischemia. J. Clin. Invest., 107:1083\u20131092, 2001.","journal-title":"J. Clin. Invest."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12188"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000337152"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1418"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.02.013"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.01927.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200111000-00004"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00599-6"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.39.10.1305"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200301000-00004"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04482"},{"key":"e_1_3_2_26_2","first-page":"157","article-title":"Inhibition of neuroretinal cell death by insulin-like growth factor-1 and its analogs","volume":"6","author":"Seigel G.M.","year":"2000","unstructured":"Seigel G.M., , Chiu L., , and Paxhia A. Inhibition of neuroretinal cell death by insulin-like growth factor-1 and its analogs. Mol Vis., 6:157\u2013163, 2000.","journal-title":"Mol Vis."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1974.03900060182003"},{"key":"e_1_3_2_28_2","first-page":"2915","article-title":"Corneal structure and sensitivity in type 1 diabetes mellitus","volume":"41","author":"Rosenberg M.E.","year":"2000","unstructured":"Rosenberg M.E., , Tervo T.M.T., , Immonen I.J., , M\u00fcller L.J., , Gronhagen-Riska C., , and Vesaluoma M.H. Corneal structure and sensitivity in type 1 diabetes mellitus. Invest. Ophthalmol. Vis Sci., 41:2915\u20132921, 2000.","journal-title":"Invest. Ophthalmol. Vis Sci."},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.03.047"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11308"},{"key":"e_1_3_2_31_2","first-page":"2610","article-title":"Influence of culture conditions on the androgen control of secretory component production by acinar cells from the rat lacrimal gland","volume":"32","author":"Hann L.E.","year":"1991","unstructured":"Hann L.E., , Kelleher R.S., , and Sullivan D.A. Influence of culture conditions on the androgen control of secretory component production by acinar cells from the rat lacrimal gland. Invest. Ophthalmol. Vis. Sci., 32:2610\u20132621, 1991.","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_2_32_2","first-page":"532e539","article-title":"Reliability of the noncontact corneal aesthesiometer and its comparison with the Cochete Bonnet aesthesiometer","volume":"18","author":"Murphy P.J.","year":"1998","unstructured":"Murphy P.J., , Lawrenson J.G., , Patel S., , and Marshall J. Reliability of the noncontact corneal aesthesiometer and its comparison with the Cochete Bonnet aesthesiometer. Ophthalmic. Physiol. Opt., 18:532e539, 1998.","journal-title":"Ophthalmic. Physiol. Opt."},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(96)00027-4"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2006.04.018"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.20.4.A266-a"}],"container-title":["Journal of Ocular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jop.2014.0017","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jop.2014.0017","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jop.2014.0017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:39:35Z","timestamp":1777646375000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jop.2014.0017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,22]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2,1]]}},"alternative-id":["10.1089\/jop.2014.0017"],"URL":"https:\/\/doi.org\/10.1089\/jop.2014.0017","relation":{},"ISSN":["1080-7683","1557-7732"],"issn-type":[{"value":"1080-7683","type":"print"},{"value":"1557-7732","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,22]]}}}