{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:49:20Z","timestamp":1777909760145,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2014,10,6]],"date-time":"2014-10-06T00:00:00Z","timestamp":1412553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To compare the 24-h changes of intraocular pressure (IOP) and mean ocular perfusion pressure (MOPP) obtained with tafluprost versus travoprost in patients with normal-tension glaucoma (NTG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study is a randomized crossover study of 50 patients newly diagnosed with NTG who received either tafluprost or travoprost given once at 9 PM for 2 months, after which they were crossed over to the other medication for another 2 months. IOP and blood pressure were measured for 24\u2009h before starting the treatment and after finishing the first and second treatment periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Forty-one patients completed the study. The mean (\u00b1standard deviation) 24-h IOP was 16.8\u00b12.0\u2009mmHg at baseline, 14.4\u00b12.2\u2009mmHg on tafluprost, and 13.6\u00b11.8\u2009mmHg on travoprost. Both prostaglandin monotherapies significantly reduced mean 24-h IOP as compared with baseline (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001, respectively), and travoprost demonstrated a lower mean 24-h IOP than tafluprost (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.044). Both treatments significantly reduced the IOP from baseline at every point over 24\u2009h. At 3 individual time points, travoprost provided a lower IOP than tafluprost: at 4 PM (13.8\u00b12.7 vs. 14.8\u00b12.6\u2009mmHg,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.041), at 6 PM (13.5\u00b12.5 vs. 14.4\u00b12.5\u2009mmHg,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.006), and at 8 PM (13.3\u00b12.5 vs. 14.5\u00b12.4\u2009mmHg,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.029). Both tafluprost and travoprost significantly increased the 24-h MOPP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.008,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.002, respectively), and travoprost demonstrated a greater 24-h MOPP than tafluprost (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.027).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Both tafluprost and travoprost were effective in lowering IOP and increasing MOPP throughout 24\u2009h in NTG. However, travoprost reduced IOP greater than tafluprost in the late afternoon and evening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2014.0034","type":"journal-article","created":{"date-parts":[[2014,10,6]],"date-time":"2014-10-06T14:24:53Z","timestamp":1412605493000},"page":"803-809","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The Circadian Changes of Intraocular Pressure and Ocular Perfusion Pressure After Tafluprost Compared with Travoprost in Normal Tension Glaucoma"],"prefix":"10.1177","volume":"30","author":[{"given":"Jonghoon","family":"Shin","sequence":"first","affiliation":[{"name":"Pusan National University"},{"name":"Pusan National University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Woong","family":"Lee","sequence":"additional","affiliation":[{"name":"Pusan National University"},{"name":"Pusan National University Hospital"},{"name":"University of California Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beom-Seok","family":"Choi","sequence":"additional","affiliation":[{"name":"Pusan National University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Young","family":"Yun","sequence":"additional","affiliation":[{"name":"Pusan National University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Ho","family":"Jung","sequence":"additional","affiliation":[{"name":"Pusan National University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"University of California Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Caprioli","sequence":"additional","affiliation":[{"name":"University of California Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,10,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.10.016"},{"key":"e_1_3_2_3_2","first-page":"97","article-title":"Collaborative Normal-Tension Glaucoma Study Group","volume":"126","author":"Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures","year":"1998","unstructured":"Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures. 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