{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:49:21Z","timestamp":1777909761775,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T00:00:00Z","timestamp":1411344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of gatifloxacin 0.5% ophthalmic solution administered twice daily for treatment of acute bacterial conjunctivitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Two identically designed, double-masked, multicenter studies in the United States and India enrolled patients 1 year or older with acute bacterial conjunctivitis. Patients were randomized to gatifloxacin 0.5% or vehicle treatment for 5 days. Clinical success in clearing conjunctival hyperemia and discharge at day 6 (primary endpoint) and day 4 and microbiological cure were determined. Isolates from positive conjunctival samples were tested for sensitivity and susceptibility. Safety measures included adverse events (AEs). Data from these 2 studies were pooled for these analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the 1437 randomized patients, 658 constituted the modified intent-to-treat population. Patient characteristics were similar between the pooled treatment groups. Clinical success occurred for 58.0% of gatifloxacin 0.5%-treated versus 45.5% vehicle-treated patients at day 6 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.001) and for 23.7% versus 15.4% in the respective groups at day 4 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.007). Microbiological cure was higher with gatifloxacin 0.5% than vehicle at days 4 and 6 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001 for both time points). The combined minimum inhibitory concentration required to inhibit 90% of isolates for gatifloxacin 0.5% was 2.0\u2009\u03bcg\/mL for gram-positive and gram-negative organisms. AEs were reported by 11.6% and 13.3% of patients in the gatifloxacin 0.5% and vehicle safety populations, respectively. One patient in each treatment group experienced a serious AE; neither was treatment related.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The 0.5% concentration of gatifloxacin ophthalmic solution was safe and effective for treatment of acute bacterial conjunctivitis with twice-daily administration for 5 days.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2014.0040","type":"journal-article","created":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T15:40:22Z","timestamp":1411400422000},"page":"815-822","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Gatifloxacin 0.5% Administered Twice Daily for the Treatment of Acute Bacterial Conjunctivitis in Patients One Year of Age or Older"],"prefix":"10.1177","volume":"30","author":[{"given":"Warren","family":"Heller","sequence":"first","affiliation":[{"name":"Arizona Center for Clinical Trials"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilou","family":"Cruz","sequence":"additional","affiliation":[{"name":"Premier Health Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin Rusi","family":"Bhagat","sequence":"additional","affiliation":[{"name":"St. George's Hospital","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse M.","family":"De Leon","sequence":"additional","affiliation":[{"name":"J&L De Leon Medical Corp"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Felix","sequence":"additional","affiliation":[{"name":"Allergan, Inc."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Villanueva","sequence":"additional","affiliation":[{"name":"Allergan, Inc."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Hollander","sequence":"additional","affiliation":[{"name":"Allergan, Inc."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"Jensen","sequence":"additional","affiliation":[{"name":"Allergan, Inc."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,9,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2415-9-13"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.75.7.507"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S10162"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-010-1426-6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2007.01006.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-011-0167-y"},{"key":"e_1_3_3_8_2","unstructured":"Britt H. 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