{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:00:55Z","timestamp":1791219655708,"version":"4.1.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T00:00:00Z","timestamp":1434672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T00:00:00Z","timestamp":1434672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2015,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To compare the efficacy and safety of 0.3% hydroxypropyl methylcellulose\/dextran (HPMC\/dextran) and 0.18% sodium hyaluronate (SH) in the treatment of ocular surface disease in patients using antiglaucoma drugs containing preservatives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This was a double-blind, randomized, parallel-group study in 70 glaucoma patients with Ocular Surface Disease Index (OSDI) score greater than 20 points and\/or presence of ocular signs. Patients were randomized to receive either preservative-free 0.3% HPMC\/dextran (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =35) or preservative-free 0.18% SH (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =35). Treatment was 1 drop in each eye, 4 times a day. Data were collected at baseline, at day 7 and day 28.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The groups were homogeneous at baseline. At day 28, both treatments showed significant improvements (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05) in the mean OSDI score, lid skin and lid margin inflammation, conjunctival injection, and expressibility of meibomian glands, corneal staining score, fluorescein tear breakup time (FBUT), and Schirmer I test. However, the mean OSDI score, lid margin inflammation and conjunctival injection showed significant improvements (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05) in the SH group at days 7 and 28, compared to the HPMC\/dextran group. FBUT and the Schirmer I test also showed significant improvements (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05) in the SH group compared to the HPMC\/dextran group, at day 28. No adverse reactions were observed in either group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Preservative-free artificial tear, 0.3% HPMC\/dextran, and 0.18% SH, caused a significant relief of the ocular surface disease in glaucoma patients. However, 0.18% SH led to a greater improvement in ocular signs and symptoms than 0.3% HPMC\/dextran.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2014.0115","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T15:51:42Z","timestamp":1434729102000},"page":"323-329","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of 0.3% Hydroxypropyl Methylcellulose\/Dextran Versus 0.18% Sodium Hyaluronate in the Treatment of Ocular Surface Disease in Glaucoma Patients: A Randomized, Double-Blind, and Controlled Study"],"prefix":"10.1177","volume":"31","author":[{"given":"Pinnita","family":"Prabhasawat","sequence":"first","affiliation":[{"name":"Mahidol University","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngamkae","family":"Ruangvaravate","sequence":"additional","affiliation":[{"name":"Mahidol University","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nattaporn","family":"Tesavibul","sequence":"additional","affiliation":[{"name":"Mahidol University","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maneerat","family":"Thewthong","sequence":"additional","affiliation":[{"name":"Mahidol University","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,6,19]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"The First Visual Impairment Project in Thailand-TVIP The Fourth National Survey of Blindness Low Vision and Major Eye Disease in Thailand 2006\u20132007."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.081224"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(89)32888-0"},{"key":"e_1_3_3_5_2","first-page":"3442","article-title":"Basal tear turnover and topical timolol in glaucoma patients and healthy controls by fluorophotometry","volume":"33","author":"Kuppens E.V.","year":"1992","unstructured":"Kuppens E.V., , Stolwijk T.R., , de Keizer R.J., , and van Best J.A. 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