{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:17:08Z","timestamp":1789906628709,"version":"4.0.1"},"reference-count":85,"publisher":"SAGE Publications","issue":"1-2","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1089\/jop.2017.0121","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T12:33:05Z","timestamp":1512477185000},"page":"141-153","source":"Crossref","is-referenced-by-count":92,"title":["Intravitreal, Subretinal, and Suprachoroidal Injections: Evolution of Microneedles for Drug Delivery"],"prefix":"10.1177","volume":"34","author":[{"given":"Rachel R.","family":"Hartman","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uday B.","family":"Kompella","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado."},{"name":"Department of Ophthalmology, University of Colorado Anschutz Medical Campus, Aurora, Colorado."},{"name":"Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, Colorado."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.1.1.99"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01977971"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2010.19"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/IIO.0000000000000062"},{"key":"B5","first-page":"62","volume":"21","author":"Williams G.A.","year":"2014","journal-title":"Rev. Ophthalmol."},{"key":"B6","first-page":"45","volume-title":"EyeNet Magazine","author":"Wilson M.E.","year":"2013"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000399"},{"key":"B8","first-page":"271","volume":"56","author":"Rivera A.M.","year":"2005","journal-title":"Acta Anaesthesiol. Belg."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2010.0082"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmecsci.2012.09.014"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-3801(99)90187-8"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181b094cf"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2005.09.022"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200410001-00002"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12026"},{"key":"B17","first-page":"81","volume":"21","author":"Karth P.A.","year":"2014","journal-title":"Rev. Opthalmol."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.4103\/2320-3897.174429"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.370"},{"key":"B20","first-page":"473","volume":"32","author":"Doshi R.R.","year":"2012","journal-title":"Retina"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.227"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1517\/14656560903081752"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.304"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.02.014"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.04.013"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2012.0144"},{"key":"B27","first-page":"1131","volume":"28","author":"Lopez R.","year":"1987","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3727\/000000001783986710"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1989.4"},{"key":"B30","first-page":"3341","volume":"33","author":"Wongpichedchai S.","year":"1992","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(92)90025-9"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-007-0718-y"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2908"},{"key":"B34","first-page":"1835","volume":"15","author":"Petersen-Jones S.M.","year":"2009","journal-title":"Mol. Vis."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002103"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30371-3"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-010-0271-y"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-008-9756-3"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-9920-7_14"},{"key":"B40","volume-title":"Apparatus and Methods for Drug Delivery Using Microneedles","author":"Prausnitz M.R.A.","year":"2015"},{"key":"B41","volume-title":"Apparatus and Methods for Ocular Injection","author":"Andino R.V.G.","year":"2015"},{"key":"B42","first-page":"2","volume":"56","author":"Eaton A.M.","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B43","first-page":"56","author":"Eaton A.M.","year":"2012","journal-title":"Retina Today"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.04.005"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1159\/000336045"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807027105"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2009.086"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0903652"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15895"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2008.107"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1007685"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412965"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2006.17.845"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2006.03.005"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.11.048"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-11-40"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/ng0501-92"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.08.008"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57377"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.17.9920"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802315"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61836-5"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.277"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802268"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414221"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1167\/15.15.20"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002865"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1512590113"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60028-2"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61376-3"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62117-0"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30783-8"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-20230"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18364"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-015-2976-4"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-016-1637-y"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-17121-0_35"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2011.169"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.11.016"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00345-1"},{"key":"B81","first-page":"1533","volume":"43","author":"Einmahl S.","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.05.045"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-9872"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-11747"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.5.6.14"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201300696"}],"container-title":["Journal of Ocular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.liebertpub.com\/doi\/full-xml\/10.1089\/jop.2017.0121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/jop.2017.0121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:42:14Z","timestamp":1777646534000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/jop.2017.0121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":85,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1089\/jop.2017.0121"],"URL":"https:\/\/doi.org\/10.1089\/jop.2017.0121","relation":{},"ISSN":["1080-7683","1557-7732"],"issn-type":[{"value":"1080-7683","type":"print"},{"value":"1557-7732","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}