{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T19:52:24Z","timestamp":1778097144710,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To compare equal concentrations (0.5%) of moxifloxacin and gatifloxacin ophthalmic solutions with regard to conjunctival bacterial reduction as well as anterior chamber penetration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>One hundred patients were divided into 2 groups. Group A received moxifloxacin 0.5% ophthalmic solution and group B received gatifloxacin 0.5% ophthalmic solution 4 times a day for 3 days before surgery and 5 times with 30\u2009min intervals on the day of surgery. Two conjunctival swabs were obtained: one before instillation of antibiotic and the second 30\u2009min after instillation of the last antibiotic drop. Specimens were sent for culture and susceptibility testing. At the time of surgery, 0.1\u2009mL of aqueous fluid was aspired, and aqueous concentration of fluoroquinolones was identified using reverse-phase high-pressure liquid chromatography assay technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The most common flora isolated was coagulase-negative\n                      <jats:italic toggle=\"yes\">Staphylococcus<\/jats:italic>\n                      (32.9%), followed by\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      (24.8%) and\n                      <jats:italic toggle=\"yes\">Corynebacterium diphtheria<\/jats:italic>\n                      (19.1%). Moxifloxacin aqueous concentration was higher compared with gatifloxacin [1.75\u2009\u00b1\u20090.98 standard deviation (SD) and 0.75\u2009\u00b1\u20090.22 SD, respectively]. This 2.3-fold difference in aqueous humor antibiotic concentrations was statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009\u2264\u20090.001). There was significant difference between the means of conjunctival colony-forming unit after antibiotic administration in both the study groups (2.17\u2009\u00b1\u20091.54 SD in group A and 1.56\u2009\u00b1\u20091.09 SD in group B).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Moxifloxacin 0.5% was found to penetrate anterior chamber more than gatifloxacin 0.5%, enforcing its use for prophylaxis before intraocular surgeries. However, gatifloxacin 0.5% eye drops were able to reduce conjunctival bacterial load, more supporting its use before extraocular and refractive surgeries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2018.0088","type":"journal-article","created":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T10:13:31Z","timestamp":1554459211000},"page":"315-318","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparative Study Between Topical Gatifloxacin 0.5% and Moxifloxacin 0.5% as a Prophylactic Measure Before Intraocular Surgery"],"prefix":"10.1177","volume":"35","author":[{"given":"Asser Ahmed Ehsan","family":"Abdel-Meguid","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Fayoum University Faculty of Medicine, Fayoum, Egypt."},{"name":"Department of Ophthalmology, Cairo University Kasr Alaini Faculty of Medicine, Cairo, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Fathy","family":"Gabr","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Aswan University Faculty of Medicine, Aswan, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Mostafa","family":"Said","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Fayoum University Faculty of Medicine, Fayoum, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Abd El Hamid","family":"Nassef","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Fayoum University Faculty of Medicine, Fayoum, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek Mohamed Ibrahim","family":"Elmenofy","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Fayoum University Faculty of Medicine, Fayoum, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,6,3]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"CD006364","article-title":"Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery","volume":"2","author":"Gower E.W.","year":"2017","unstructured":"Gower E.W., , Lindsley K., , Tulenko S.E., , Nanji A.A., , Leyngold I., , and McDonnell P.J. 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