{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:51:33Z","timestamp":1777909893275,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To investigate the anti-(lymph)angiogenic and anti-inflammatory effects of albendazole and to study whether these effects are additive with bevacizumab therapy in a murine corneal suture model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Corneal neovascularization (NV) and lymphangiogenesis (LY) were compared in a corneal suture model after administration of a subconjunctival injection of albendazole, bevacizumab, dexamethasone, or phosphate-buffered saline (PBS). Immunohistochemical staining and analysis were performed in each group. Real-time polymerase chain reaction (RT-PCR) was performed to quantify the expression of inflammatory cytokines (tumor necrosis factor [TNF]-alpha and interleukin-6), vascular endothelial growth factor (VEGF)-A, VEGF-C, vascular endothelial growth factor receptor (VEGFR)-2, and VEGFR-3. To evaluate the additive effect of albendazole, corneal NV and LY were also analyzed in a combined group of albendazole and bevacizumab therapy and the additive effect was compared with that in the group of double dose of bevacizumab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The albendazole group showed less NV and less LY compared with the PBS control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.01). When albendazole was combined with bevacizumab therapy, a significant decrease in NV and LY was seen compared with bevacizumab treatment alone, and with albendazole alone (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      values &lt;0.05). The combination group showed better antilymphangiogenesis effect than the group of double dose bevacizumab. The albendazole-treated group showed reduced expression of VEGF-A, VEGF-C, TNF-alpha, and VEGFR-2 compared with corneas from the PBS group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value &lt;0.05 in all respective comparisons).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Albendazole significantly decreased NV and LY in the cornea. This beneficial effect is additively enhanced when combined with bevacizumab treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2018.0103","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T11:25:06Z","timestamp":1556537106000},"page":"254-261","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Antiangiogenesis Effect of Albendazole on the Cornea"],"prefix":"10.1177","volume":"35","author":[{"given":"Yang Kyung","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Young","family":"Shin","sequence":"additional","affiliation":[{"name":"Research Institute of Medical Science, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Uehara","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Utah School of Medicine, Salt Lake City, Utah."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balamurali","family":"Ambati","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Utah School of Medicine, Salt Lake City, Utah."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05249"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2018"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20465"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.42"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23874"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2013.01.001"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0570"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-1380"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0027"},{"key":"e_1_3_3_11_2","first-page":"680","article-title":"Repurposing drugs in oncology (ReDO)-propranolol as an anti-cancer agent","volume":"10","author":"Pantziarka P.","year":"2016","unstructured":"Pantziarka P., , Bouche G., , Sukhatme V., et al. 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