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In the past 20 years, the conservative management of progressive corneal ectasia has changed, thanks to this procedure that produces strengthening of the corneal tissue through the photochemical reaction generated by the combined action of riboflavin and ultraviolet A radiation. Many modified protocols have been implemented to halt the progression of the disease and to delay or prevent visual loss and surgical procedures such as corneal transplantation. Because of the variety of different protocols that are currently used, the results that are being reported are very variable, and could generate some confusion in relation to the true efficacy of the procedure. The aim of this review was to provide an overview of the aforementioned protocols that are designed to maintain the efficacy of CXL in halting the progression of the disease but avoiding the major limitations of the procedure.<\/jats:p>","DOI":"10.1089\/jop.2018.0144","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T10:34:57Z","timestamp":1569321297000},"page":"475-490","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Invasive Pharmacology Outcomes with Different Corneal Cross-Linking Protocols: A Review"],"prefix":"10.1177","volume":"35","author":[{"given":"Diego Alejandro","family":"Valera-Cornejo","sequence":"first","affiliation":[{"name":"Cl\u00ednica Vista, Cataract and Refractive Surgery Department, Lima, Peru."},{"name":"Miguel Hernandez University, Alicante, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Vega-Estrada","sequence":"additional","affiliation":[{"name":"Miguel Hernandez University, Alicante, Spain."},{"name":"VIssum Ophthalmic Corporation, Alicante, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge L.","family":"Alio","sequence":"additional","affiliation":[{"name":"Miguel Hernandez University, Alicante, Spain."},{"name":"VIssum Ophthalmic Corporation, Alicante, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,11,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700652"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(97)00119-7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/795738"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2013.01.002"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02220-1"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.10.028"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.196493"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2014.962176"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.188342"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.164228"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/869015"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2014.06.001"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2013.03.026"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20100212-09"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.02.005"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2013.05.022"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12595"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12235"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20141021-06"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13032"},{"key":"e_1_3_3_22_2","first-page":"306","article-title":"Photochemical researches, part V: on the measurement of the chemical action of direct and diffuse sunlight","volume":"12","author":"Bunsen R.W.","year":"1862","unstructured":"Bunsen R.W., , and Roscoe H.E. 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