{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:40:14Z","timestamp":1788813614704,"version":"build-2803163510"},"reference-count":39,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To compare the clinical outcome of intravitreal dexamethasone implant versus oral acetazolamide in patients with cystoid macular edema (CME) secondary to retinitis pigmentosa (RP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Multicenter, prospective, propensity-score-matched, comparative study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Eyes with RP and CME were treated either with intravitreal dexamethasone implant or with oral acetazolamide (500\u2009mg\/day). Patients were evaluated monthly and followed up for 12 months. Primary outcome measures were changes in central retinal thickness and best corrected visual acuity (BCVA). Adverse events were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Propensity score matching resulted in 2 groups of 30 eyes each. All patients completed 12 months of follow-up. Mean central retinal thickness decreased from 535\u2009\u03bcm at baseline to 208\u2009\u03bcm at month 12 in the dexamethasone implant group and from 519 to 339\u2009\u03bcm in the oral acetazolamide group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001, Student's\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test). Mean BCVA average change from baseline during the study (area-under-the-curve approach) was \u22120.084 logarithm of the minimum angle of resolution (logMAR) (+4.2 letters) in the dexamethasone implant group and \u22120.032 (+1.6 letters) in the oral acetazolamide group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.05, Mann\u2013Whitney\n                      <jats:italic toggle=\"yes\">U<\/jats:italic>\n                      test). Patients in the dexamethasone implant group required on average 1.7 treatments during 1 year of therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In this study, intravitreal dexamethasone implant produced better anatomic and functional improvements over oral acetazolamide in patients affected by CME secondary to RP. Larger, randomized clinical trials with longer follow-up are warranted to confirm these data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2018.0153","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T10:16:01Z","timestamp":1577700961000},"page":"190-197","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Dexamethasone Implant Produces Better Outcomes than Oral Acetazolamide in Patients with Cystoid Macular Edema Secondary to Retinitis Pigmentosa"],"prefix":"10.1177","volume":"36","author":[{"given":"Daniele","family":"Veritti","sequence":"first","affiliation":[{"name":"Department of Medicine\u2014Ophthalmology and University of Udine, Udine, Italy."},{"name":"Istituto Europeo di Microchirurgia Oculare\u2014IEMO, Udine, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Sarao","sequence":"additional","affiliation":[{"name":"Department of Medicine\u2014Ophthalmology and University of Udine, Udine, Italy."},{"name":"Istituto Europeo di Microchirurgia Oculare\u2014IEMO, Udine, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"De Nadai","sequence":"additional","affiliation":[{"name":"Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy."},{"name":"Center for Retinitis Pigmentosa of Veneto Region, Camposampiero Hospital, Azienda ULSS 6 Euganea, Padova, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzio","family":"Chizzolini","sequence":"additional","affiliation":[{"name":"Center for Retinitis Pigmentosa of Veneto Region, Camposampiero Hospital, Azienda ULSS 6 Euganea, Padova, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Parmeggiani","sequence":"additional","affiliation":[{"name":"Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy."},{"name":"Center for Retinitis Pigmentosa of Veneto Region, Camposampiero Hospital, Azienda ULSS 6 Euganea, Padova, Italy."},{"name":"Center for the Study of Inflammation, University of Ferrara, Ferrara, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Perissin","sequence":"additional","affiliation":[{"name":"Department of Department of Medicine, University of Udine, Udine, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Lanzetta","sequence":"additional","affiliation":[{"name":"Department of Medicine\u2014Ophthalmology and University of Udine, Udine, Italy."},{"name":"Istituto Europeo di Microchirurgia Oculare\u2014IEMO, Udine, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,4,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920211795860107"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69740-7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920211795860125"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.110"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004170050175"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.07.008"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.iae.0000254897.86389.a5"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00446-2"},{"key":"e_1_3_3_10_2","first-page":"211","article-title":"Quantification of disorders of the blood-aqueous humor barrier in retinitis pigmentosa\u2014initial results","volume":"204","author":"K\u00fcchle M.","year":"1994","unstructured":"K\u00fcchle M., , Nguyen N.X., , Schalnus R., et al. 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