{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:51:50Z","timestamp":1777909910765,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Treatment of persistent ocular discomfort in patients with Cogan's epithelial basement membrane dystrophy (EBMD) is a challenge for ophthalmologists. This study aimed to determine the efficacy of a topical heparan sulfate mimetic polymer (HSMP) in reducing ocular discomfort in EBMD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective, noninterventional study included 22 consecutive patients in 3 tertiary ophthalmological units with spontaneous, recurrent, acute ocular pain, resistant to various topical lubricants. After EBMD diagnosis, HSMP treatment was initiated while lubricating eye drops were continued. The main study outcome was the change in ocular discomfort assessed using the ocular surface disease index (OSDI) from initiation of treatment to last follow-up visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean OSDI decreased from 46.7\u2009\u00b1\u200922.3 to 31.6\u2009\u00b1\u200917.4 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001) at first visit and 32.5\u2009\u00b1\u200917.9 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.01) at last visit. The rate of patients with severe ocular surface disease (OSDI &gt;33) decreased from 68.2% to 36.4% at first visit and 42.9% at last visit. After a median follow-up of 8.5 months, 7 (31.8%) patients discontinued the HSMP treatment due to a marked improvement in ocular surface comfort and no recurrence of ocular pain, 5 (22.7%) due to lack of efficacy, and 1 (4.5%) due to an ocular adverse event (not treatment related). Eight patients continued treatment after the last visit and 1 patient was lost to follow-up. Globally, HSMP prevented acute painful episodes in 11 (61.1%) of 18 patients followed for \u223c4 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Topical HSMP may be an option for alleviating ocular discomfort in patients with EBMD resistant to standard symptomatic treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2019.0015","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T09:25:00Z","timestamp":1561109100000},"page":"359-365","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of a Topical Heparan Sulfate Mimetic Polymer on Ocular Surface Discomfort in Patients with Cogan's Epithelial Basement Membrane Dystrophy"],"prefix":"10.1177","volume":"35","author":[{"given":"Marc","family":"Labetoulle","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Bic\u00eatre Hospital, APHP, South Paris University, Le Kremlin Bic\u00eatre, France."},{"name":"IMVA (Centre for Immunology of Viral Infections and Autoimmune Diseases), UMR 1184, INSERM, CEA, South Paris University, Fontenay aux Rosex, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bic\u00eatre Hospital, APHP, South Paris University, Le Kremlin Bic\u00eatre, France."},{"name":"IMVA (Centre for Immunology of Viral Infections and Autoimmune Diseases), UMR 1184, INSERM, CEA, South Paris University, Fontenay aux Rosex, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"M'Garrech","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bic\u00eatre Hospital, APHP, South Paris University, Le Kremlin Bic\u00eatre, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godefroy","family":"Kaswin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bic\u00eatre Hospital, APHP, South Paris University, Le Kremlin Bic\u00eatre, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9n\u00e9dicte","family":"Dupas","sequence":"additional","affiliation":[{"name":"CHNO Quinze-Vingts, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Baudouin","sequence":"additional","affiliation":[{"name":"CHNO Quinze-Vingts, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Barreau","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bic\u00eatre Hospital, APHP, South Paris University, Le Kremlin Bic\u00eatre, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tristan","family":"Bourcier","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, New Civil Hospital, Strasbourg University Hospital, FMTS, Strasbourg, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Chiambaretta","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Clermont-Ferrand, Gabriel-Montpied Hospital, Clermont-Ferrand, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,7,24]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"213","article-title":"Microcystic dystrophy of the corneal epithelium","volume":"62","author":"Cogan D.G.","year":"1964","unstructured":"Cogan D.G., , Donaldson D.D., , Kuwabara T., , and Marshall D. Microcystic dystrophy of the corneal epithelium. Trans. Am. Ophthalmol. Soc. 62:213\u2013225, 1964.","journal-title":"Trans. Am. Ophthalmol. Soc"},{"key":"e_1_3_3_3_2","first-page":"320","article-title":"Observations on Cogan's microcystic dystrophy on the corneal epithelium","volume":"63","author":"Guerry D.","year":"1965","unstructured":"Guerry D. Observations on Cogan's microcystic dystrophy on the corneal epithelium. Trans. Am. Ophthalmol. Soc. 63:320\u2013334, 1965.","journal-title":"Trans. Am. Ophthalmol. Soc"},{"key":"e_1_3_3_4_2","first-page":"897","volume-title":"Cornea. Fundamentals, Diagnosis and Management","author":"Laibson P","year":"2005","unstructured":"Laibson P. Anterior corneal dystrophies. In: Krachmer J.H., , Mannis M.J., , Holland E.J., eds.. Cornea. Fundamentals, Diagnosis and Management. 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