{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:38:41Z","timestamp":1782488321299,"version":"3.54.5"},"reference-count":32,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To compare the safety and efficacy of an intraoperative transzonular injection of triamcinolone\u2013moxifloxacin (Imprimis' Tri-Moxi 15\u2009mg\/1\u2009mg\/mL) to topical drops in patients undergoing cataract surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Between January 2017 and October 2017, patients undergoing phacoemulsification cataract surgery by a single surgeon at the Penn State Eye Center were offered a single intraoperative injection of transzonular triamcinolone\u2013moxifloxacin in lieu of perioperative drops. Between November 2017 and July 2018, the transzonular injection was not offered, and all patients who underwent surgery by the same surgeon received a drop regimen consisting of polymyxin b\/trimethoprim and prednisolone acetate 1%. Patients were seen 1 day, 1 week, and 6\u20139 weeks postoperatively. Outcome measures included incidence of intraoperative complications, postoperative breakthrough inflammation, cystoid macular edema, and infectious sequela.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the 198 eyes, 99 from 73 patients received the injection and 99 from 82 patients received topical drops. One (1%) intraoperative posterior capsule tear occurred in each group. Eleven (11.1%) eyes in the injection group and 3 (3%) in the drop group experienced symptomatic breakthrough inflammation necessitating treatment (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.0488). One (1%) eye in the injection group and zero (0%) in the drop group developed clinically significant macular edema (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20091.0). No instances of elevated intraocular pressure or infectious sequela occurred in either group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20091.0).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Transzonular injection of triamcinolone\u2013moxifloxacin may be associated with an increased incidence of breakthrough inflammation compared to topical drops.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2019.0097","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T16:26:33Z","timestamp":1571156793000},"page":"565-570","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Transzonular Triamcinolone\u2013Moxifloxacin Versus Topical Drops for the Prophylaxis of Postoperative Inflammation After Cataract Surgery"],"prefix":"10.1177","volume":"35","author":[{"given":"Rishi","family":"Singhal","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Penn State College of Medicine, Hershey, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Penn State College of Medicine, Hershey, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"O'Rourke","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Penn State College of Medicine, Hershey, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid U.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Penn State College of Medicine, Hershey, Pennsylvania."},{"name":"Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth M.","family":"Pantanelli","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Penn State College of Medicine, Hershey, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,12,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(13)80071-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.iae.0000249577.92800.c0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.10.051"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joco.2016.05.002"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000216"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e32835b0716"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/21.3.168"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.02.037"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000329"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20140605-01"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.03.016"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(85)34001-0"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1995.01100060051031"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(00)00832-4"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(01)01185-3"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.12.1380"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(04)80113-9"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-005-1126-9"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01433.x"},{"key":"e_1_3_3_21_2","first-page":"1499","article-title":"A prospective, open-label study to compare the efficacy and the safety of topical loteprednol etabonate and topical flurbiprofen sodium in patients with post-operative inflammation after cataract extraction","volume":"6","author":"Bannale S.G.","year":"2012","unstructured":"Bannale S.G., , Pundarikaksha H.P., , and Sowbhagya H.N. 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