{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:40:03Z","timestamp":1791841203998,"version":"4.3.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Disturbances that affect the inside of the eyeball tend to be highly harmful since they compromise the homeostasis of this organ. Alongside this, the eyeball has several anatomical barriers that prevent the entry of substances. This way, diseases that affect the retina are among those that present greater difficulty in the treatment. In many cases, abnormal proliferation of blood vessels (neovascularization) occurs from the lower layers of the retina. This process damages its structure physiologically and anatomically, causing the rapid and irreversible loss of visual capacity. This work aims to develop nanosuspensions of quantum dots (QDs) conjugated to bevacizumab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Two types of QDs were produced by aqueous route, stabilized with chitosan conjugated to bevacizumab. The antiangiogenic activity was evaluated in the chorioallantoic membrane model, in which results indicated discrete activity at the doses tested. Samples were assessed for their biosafety in animals, after intravitreal administration, by means of electroretinography (ERG), intraocular pressure (IOP) measurement, histological, morphometric, and immunohistochemical evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>No significant alterations were detected in ERG that suggests damage to retinal function by the samples. No significant changes in IOP were also detected. The histological sections did not show signs of acute inflammation, although there was evidence of late retinal damage. The immunohistochemical analysis did not detect any apoptotic bodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Preliminary results suggest that QDs present potential applicability in ocular therapy, and it is necessary to better characterize their\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      behavior and to optimize their dosage.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2019.0108","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T22:15:35Z","timestamp":1591827335000},"page":"467-483","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Bevacizumab-Conjugated Quantum Dots:\n                    <i>In Vitro<\/i>\n                    Antiangiogenic Potential and Biosafety in Rat Retina"],"prefix":"10.1177","volume":"36","author":[{"given":"Cleildo P.","family":"Santana","sequence":"first","affiliation":[{"name":"Technology Center in Medicine Development\u2014CT-Tecnologia Farmac\u00eautica, Faculty of Pharmacy, Federal University of Minas Gerais\u2014UFMG, Belo Horizonte, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra A.P.","family":"Mansur","sequence":"additional","affiliation":[{"name":"Center of Nanoscience, Nanotechnology and Innovation\u2014CeNano, 2I, School of Engineering, Federal University of Minas Gerais\u2014UFMG, Belo Horizonte, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman S.","family":"Mansur","sequence":"additional","affiliation":[{"name":"Center of Nanoscience, Nanotechnology and Innovation\u2014CeNano, 2I, School of Engineering, Federal University of Minas Gerais\u2014UFMG, Belo Horizonte, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Armando da","family":"Silva-Cunha","sequence":"additional","affiliation":[{"name":"Technology Center in Medicine Development\u2014CT-Tecnologia Farmac\u00eautica, Faculty of Pharmacy, Federal University of Minas Gerais\u2014UFMG, Belo Horizonte, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,7,24]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/582842"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/582060"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31822480f9"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3310\/hta19780"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.07.041"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.15.47"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2017.11.010"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1483"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochemrev.2017.01.002"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S138624"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-9745"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1109\/TNB.2007.891883"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2019.06.022"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.05.093"},{"key":"e_1_3_4_16_2","first-page":"1","article-title":"Corosolic acid: antiangiogenic activity and safety of intravitreal injection in rats eyes","author":"Toledo C.R.","year":"2019","unstructured":"Toledo C.R., , Pereira V.V., , Dourado L.F.N., , Paiva M.R.B., , and Silva-Cunha A. Corosolic acid: antiangiogenic activity and safety of intravitreal injection in rats eyes. Doc. Ophthalmol. 1\u201314, 2019","journal-title":"Doc. Ophthalmol"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-017-9599-5"},{"key":"e_1_3_4_18_2","first-page":"1667","article-title":"Effects of two new synthesized heterocyclic compounds on proliferation and tube formation of endothelial cells and on angiogenesis in chicken chorioallantoic membrane","volume":"74","author":"Iranmanesh M.","year":"2017","unstructured":"Iranmanesh M., , Mashkani B., , Sadeghnia H.R., et al. Effects of two new synthesized heterocyclic compounds on proliferation and tube formation of endothelial cells and on angiogenesis in chicken chorioallantoic membrane. Acta Pol. Pharm. 74:1667\u20131673, 2017.","journal-title":"Acta Pol. Pharm"},{"key":"e_1_3_4_19_2","first-page":"1","article-title":"Evaluation of anti-angiogenic activities of aqueous extracts of regular and selenium-rich green teas using chick chorioallantoic membrane as an experimental model","volume":"7","author":"Molan A.L.","year":"2019","unstructured":"Molan A.L., , Wei W.H., , and Vuthijumnonk J. Evaluation of anti-angiogenic activities of aqueous extracts of regular and selenium-rich green teas using chick chorioallantoic membrane as an experimental model. Am. J. L. Sci. Res. 7:1\u20138, 2019.","journal-title":"Am. J. L. Sci. Res"},{"key":"e_1_3_4_20_2","first-page":"60","article-title":"Folic acid and zinc inhibit angiogenesis in chicken chorioallontoic membrane model via angiogenic factor genes","volume":"60","author":"\u00c7oban Z.D.","year":"2018","unstructured":"G\u00fcran, \u015e., \u00c7oban Z.D., , Fermanli O., , Ayding\u00f6z E., , and \u0130pek E. Folic acid and zinc inhibit angiogenesis in chicken chorioallontoic membrane model via angiogenic factor genes. Gulhane Med. J. 60:60\u201367, 2018.","journal-title":"Gulhane Med. J"},{"key":"e_1_3_4_21_2","first-page":"609","article-title":"Conjugation of cell-penetrating peptides with poly (lactic-co-glycolic acid)-polyethylene glycol nanoparticles improves ocular drug delivery","volume":"10","author":"Vasconcelos A.","year":"2015","unstructured":"Vasconcelos A., , Vega E., , P\u00e9rez Y., et al. Conjugation of cell-penetrating peptides with poly (lactic-co-glycolic acid)-polyethylene glycol nanoparticles improves ocular drug delivery. Int. J. Nanomed. 10:609, 2015.","journal-title":"Int. J. Nanomed"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2017.sE21"},{"key":"e_1_3_4_23_2","first-page":"1","article-title":"Ocular safety assessment of sodium iodate in cynomolgus monkeys: characterization of a classic retinal toxicant","author":"Liu C.N.","year":"2017","unstructured":"Liu C.N., , Peng Q., , Yates D.W., et al. Ocular safety assessment of sodium iodate in cynomolgus monkeys: characterization of a classic retinal toxicant. Toxicol. Res. Appl. 1, 2017.","journal-title":"Toxicol. Res. Appl"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/0192623318770379"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2017.1302590"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2017.12.002"},{"key":"e_1_3_4_27_2","unstructured":"Fishman G.A. Birch D.G. Holder G.E. and Brigell M.G. Electrophysiologic testing in disorders of the retina optic nerve and visual pathway. The Foundation of the American Academy of Ophthalmology 2001."},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00683-x"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-22429"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12414"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523804214043"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(85)90214-7"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-006-0326-0"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-016-3531-7"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2017.0063"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.06.050"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2018.0021"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1111-y"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2018.11.010"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-23120"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21742"}],"container-title":["Journal of Ocular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jop.2019.0108","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jop.2019.0108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jop.2019.0108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:43:41Z","timestamp":1777646621000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jop.2019.0108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,1]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,7,1]]}},"alternative-id":["10.1089\/jop.2019.0108"],"URL":"https:\/\/doi.org\/10.1089\/jop.2019.0108","relation":{},"ISSN":["1080-7683","1557-7732"],"issn-type":[{"value":"1080-7683","type":"print"},{"value":"1557-7732","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,1]]}}}