{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:52:11Z","timestamp":1777909931545,"version":"3.51.4"},"reference-count":76,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Cataracts are the leading cause of blindness worldwide, resulting in over 30 million surgeries each year. These cases are expected to double within the next 10 years. About 25% of all patients develop secondary cataracts or posterior capsule opacification (PCO) postsurgery. PCO is a vision impairment disorder that develops from myofibroblasts migration and contraction that deforms the capsule surrounding the lens. Currently, Nd:YAG laser therapy is used to treat PCO; however, laser is not available worldwide and adverse side effects may arise. Thus, there is a considerable unmet need for more efficacious and convenient preventive treatments for PCO. Our work focuses on engineering an innovative, prophylactic sustained release platform for DNA-based nanocarriers to further reduce the incidence of PCO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Novel, optically clear, self-assembled poly(\n                      <jats:sc>d<\/jats:sc>\n                      ,\n                      <jats:sc>l<\/jats:sc>\n                      -lactic-\n                      <jats:italic toggle=\"yes\">co<\/jats:italic>\n                      -glycolic acid)-\n                      <jats:italic toggle=\"yes\">b<\/jats:italic>\n                      -poly(ethylene glycol) (PLGA-PEG) triblock copolymer hydrogels were used for the sustained release of the DNA-based nanocarriers (3DNA\n                      <jats:sub>\u00ae<\/jats:sub>\n                      ) loaded with cytotoxic doxorubicin (DOX) and targeted with a monoclonal antibody called G8 (3DNA:DOX:G8), which is specific to cells responsible for PCO.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The 29 (w\/v)% polymer hydrogels with the 3DNA nanocarriers presented over 80% of light transmittance, soft mechanical properties (&lt;350 Pa), and sustained release for 1 month.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In this work, we show for the first time that the hydrophobic PLGA-PEG-PLGA hydrogels can be used as platforms for sustained delivery of nucleic acid-based nanocarriers. This work demonstrates that polymeric formulations can be used for the extended delivery of ocular therapeutics and other macromolecules to treat a variety of ocular conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2019.0145","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T23:01:31Z","timestamp":1590706891000},"page":"447-457","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Extended Release of Doxorubicin-Loaded 3DNA Nanocarriers from\n                    <i>In-Situ<\/i>\n                    Forming, Self-Assembled Hydrogels"],"prefix":"10.1177","volume":"36","author":[{"given":"Laura L.","family":"Osorno","sequence":"first","affiliation":[{"name":"Biomimetic and Biohybrid Materials, Biomedical Devices, and Drug Delivery Laboratories, Department of Biomedical Engineering, Rowan University, Glassboro, New Jersey, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie D.R.","family":"Medina","sequence":"additional","affiliation":[{"name":"Biomimetic and Biohybrid Materials, Biomedical Devices, and Drug Delivery Laboratories, Department of Biomedical Engineering, Rowan University, Glassboro, New Jersey, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel E.","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Biomimetic and Biohybrid Materials, Biomedical Devices, and Drug Delivery Laboratories, Department of Biomedical Engineering, Rowan University, Glassboro, New Jersey, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Mosley","sequence":"additional","affiliation":[{"name":"Biomimetic and Biohybrid Materials, Biomedical Devices, and Drug Delivery Laboratories, Department of Biomedical Engineering, Rowan University, Glassboro, New Jersey, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Biomimetic and Biohybrid Materials, Biomedical Devices, and Drug Delivery Laboratories, Department of Biomedical Engineering, Rowan University, Glassboro, New Jersey, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,24]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1586\/17512433.1.1.145"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-016-0339-2"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2005.09.004"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2006.07.024"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2004.12.006"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2014.923065"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092830"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/b605640g"},{"key":"e_1_3_4_10_2","first-page":"48678","article-title":"Amphiphilic PLGA-PEG-PLGA triblock copolymer nanogels varying in gelation temperature and modulus for the extended and controlled release of hyaluronic acid. 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