{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:52:14Z","timestamp":1777909934621,"version":"3.51.4"},"reference-count":51,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This study aims to compare subfoveal choroidal thicknesses (SFCTs) after intravitreal dexamethasone (IVD) or intravitreal aflibercept (IVA) treatment in patients with persistent diabetic macular edema (DME) unresponsive to intravitreal ranibizumab (IVR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study consisted of patients with DME unresponsive to IVR treatment in which 37 were administered 1 dose IVD (group A) and 34 patients who were administered 3 doses of IVA (group B), as well as 35 healthy individuals (group C). Detailed ophthalmological examination and optical coherence tomography parameters of group A and group B, including central retinal thickness and SFCT, were retrospectively evaluated before and after treatment. Results from preinjection, and 1, 2, and 3 months after injection were analyzed. Results of group A and group B were compared within themselves and also compared with group C.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      SFCT measurements were compared within group A and group B (1\u2009=\u2009preinjection; 2\u2009=\u20091 month postinjection; 3\u2009=\u20092 months postinjection; 4\u2009=\u20093 months postinjection). There was significant thinning in SFCT between 1\u20132, 1\u20133, 1\u20134, 2\u20133, 2\u20134, and 3\u20134 time intervals within both group A and group B (both\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Comparison of SFCT measurements showed preinjection, 1-, and 2-month values of group A were significantly thicker than those of group C (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas there was no significant difference between 3-month values (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.09). Preinjection, 1-, and 2-month values of group B were significantly thicker than those of group C (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas there was no significant difference between 3-month values (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.06).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Three month follow-up showed thinning in SFCT measurements in patients with persistent DME unresponsive to IVR who were applied IVD or IVA treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2020.0004","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T22:57:46Z","timestamp":1590620266000},"page":"629-635","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Choroidal Thickness After Dexamethasone Implant or Aflibercept in Patients with Diabetic Macular Edema Persistent to Ranibizumab"],"prefix":"10.1177","volume":"36","author":[{"given":"Mustafa","family":"Aksoy","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Baskent University, Ankara, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gursel","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Baskent University, Ankara, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irfan","family":"Vardarli","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Knappschaftskrankenhaus, Klinikum Vest GmbH, Academic Teaching Hospital, Ruhr-University Bochum, Recklinghausen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imren","family":"Akkoyun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Baskent University, Ankara, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,10,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)00033-1"},{"key":"e_1_3_3_3_2","first-page":"1953","article-title":"Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells","volume":"47","author":"Antonetti D.A.","year":"1998","unstructured":"Antonetti D.A., , Barber A.J., , Khin S., et al. 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