{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:25:22Z","timestamp":1788200722337,"version":"build-2803163510"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Many researchers have reported that vitamin A (VA) deficiency is related to chalazion. The purpose of this article is to clarify the effects of VA supplementation on chalazion in young children with VA deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Forty-eight young children with VA deficiency suffering from chalazia were enrolled from our previous studies and were followed continuously for 1 year. Serum VA levels and recurrence of chalazion were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean serum VA levels increased after supplementation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20092.17E-15). The mean serum VA levels of subjects who experienced recurrence were lower than those without recurrence (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.015). The recurrence rate and the mean recurrent frequency after supplementation were lower than before supplementation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.01,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20096E-6); the mean time to the first recurrence of subjects without recurrence was longer after supplementation than before supplementation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Oral VA supplementation could reduce the recurrence of chalazion in young children with preexisting VA deficiency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2020.0115","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T11:44:12Z","timestamp":1622115852000},"page":"354-359","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The Effect of Oral Vitamin A Supplementation on Chalazion in Young Children with Vitamin A Deficiency: A Pilot Study"],"prefix":"10.1177","volume":"37","author":[{"given":"Xu","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Bishan Hospital of Chongqing, Chongqing, China."},{"name":"Department of Ophthalmology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Basis of Child Development and Critical Disorders, Chongqing Engineering Research Center of Stem Cell Therapy, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Basis of Child Development and Critical Disorders, Chongqing Engineering Research Center of Stem Cell Therapy, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Basis of Child Development and Critical Disorders, Chongqing Engineering Research Center of Stem Cell Therapy, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(96)80064-6"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.83.12.e1409"},{"key":"e_1_3_4_4_2","volume-title":"Chalazion","author":"Jordan G.A.","year":"2020","unstructured":"Jordan G.A., , and Beier K. Chalazion. Treasure Island, FL: StatPearls; 2020."},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0181-5512(04)96109-8"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31821de36f"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.07.033"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(68)80052-1"},{"key":"e_1_3_4_9_2","first-page":"245","article-title":"Solving the micronutrient problem in the Asia Pacific region","volume":"7","author":"Darnton-Hill I.","year":"1998","unstructured":"Darnton-Hill I. Solving the micronutrient problem in the Asia Pacific region. Asia Pac. J. Clin. Nutr. 7:245\u2013255, 1998.","journal-title":"Asia Pac. J. Clin. Nutr"},{"key":"e_1_3_4_10_2","unstructured":"World Health Organization. EN Nutrition\u2014Publications\u2014Micronutrients\u2014Vitamin A deficiency\u2014Global prevalence of vitamin A deficiency in populations at risk 1995\u20132005. Geneva: World Health Organization;. 2009."},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-020-00589-x"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.3.446-464.2005"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2013.08.016"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(68)80053-3"},{"key":"e_1_3_4_15_2","first-page":"63","article-title":"Serum vitamin A levels in patients with chalazion","volume":"6","author":"Malekahmadi M.","year":"2017","unstructured":"Malekahmadi M., , Farrahi F., , and Tajdini A. Serum vitamin A levels in patients with chalazion. Med. Hypothesis Discov. Innov. Ophthalmol. J. 6:63\u201366, 2017.","journal-title":"Med. Hypothesis Discov. Innov. Ophthalmol. J"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.02.020"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c4044"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(92)90143-5"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6997c"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000960305"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6997e"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.94053"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.3928\/01913913-20160929-03"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu9020159"}],"container-title":["Journal of Ocular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jop.2020.0115","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jop.2020.0115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jop.2020.0115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:44:19Z","timestamp":1777646659000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jop.2020.0115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,28]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,8,1]]}},"alternative-id":["10.1089\/jop.2020.0115"],"URL":"https:\/\/doi.org\/10.1089\/jop.2020.0115","relation":{},"ISSN":["1080-7683","1557-7732"],"issn-type":[{"value":"1080-7683","type":"print"},{"value":"1557-7732","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,28]]}}}