{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:52:35Z","timestamp":1777909955520,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"\n Purpose:<\/jats:title>\n To compare the effectiveness of topical surfactant and 3% sodium chloride (NaCl) in the treatment of corneal edema occurring after cataract surgery.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Ninety eyes of 90 patients with no corneal disease who underwent cataract surgery were included in the study. Thirty eyes without corneal edema comprised group 1. Patients with corneal edema were divided into two groups: those treated with 3% NaCl (group 2, 30 eyes) and those treated with surfactant drop (group 3, 30 eyes).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The mean age was 70.8\u2009\u00b1\u20096.6 years, with no significant age difference between the groups. Preoperatively, there was no significant difference in mean central corneal thickness (CCT) or mean endothelial cell count (ECC) among the groups (\n P<\/jats:italic>\n \u2009=\u20090.999). On postoperative day 1, CCT was significantly lower in group 1 (\n P<\/jats:italic>\n \u2009<\u20090.001) but did not differ between groups 2 and 3 (\n P<\/jats:italic>\n \u2009=\u20090.999). There was no significant difference between groups in terms of ECC (\n P<\/jats:italic>\n \u2009>\u20090.05). At postoperative day 7 and 14, CCT differed significantly between groups 1 and 2 (\n P<\/jats:italic>\n \u2009<\u20090.001) and between groups 2 and 3 (\n P<\/jats:italic>\n \u2009=\u20090.001), with no significant difference between groups 1 and 3 (\n P<\/jats:italic>\n \u2009=\u20090.474). ECC was significantly higher in group 1 (\n P<\/jats:italic>\n \u2009<\u20090.05), whereas there was no significant difference between groups 2 and 3 (\n P<\/jats:italic>\n \u2009>\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Topical pulmonary surfactant may be a more effective treatment option than 3% hypertonic NaCl for the treatment of corneal edema that develops after cataract surgery.<\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/jop.2020.0121","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T15:20:55Z","timestamp":1612797655000},"page":"209-214","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Pulmonary Surfactant in the Treatment of Corneal Edema"],"prefix":"10.1177","volume":"37","author":[{"given":"Tuncay","family":"Artu\u00e7","sequence":"first","affiliation":[{"name":"Nusaybin Public Hospital, Eye Clinic, Mardin, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed","family":"Batur","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Van Y\u00fcz\u00fcnc\u00fc Y\u0131l University, Van, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erbil","family":"Seven","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Van Y\u00fcz\u00fcnc\u00fc Y\u0131l University, Van, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serek","family":"Tekin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Van Y\u00fcz\u00fcnc\u00fc Y\u0131l University, Van, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammet Derda","family":"\u00d6zer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Van Y\u00fcz\u00fcnc\u00fc Y\u0131l University, Van, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,5,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1076\/soph.17.3.110.14783"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30544-5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2012.03.006"},{"key":"e_1_3_3_5_2","first-page":"1135","article-title":"Pseudophakic bullous keratopathy","volume":"91","author":"Rao G.N.","year":"1984","unstructured":"Rao G.N., , Aquavella J.V., , Goldberg S.H., , and Berk S.L. Pseudophakic bullous keratopathy. Relationship to preoperative corneal endothelial status. Ophthalmology., 91:1135\u20131140, 1984.","journal-title":"Relationship to preoperative corneal endothelial status. Ophthalmology."},{"key":"e_1_3_3_6_2","first-page":"155","volume-title":"Ophthalmology","author":"Yanoff M.","year":"2018","unstructured":"Yanoff M., and Duker J.S. Ophthalmology, 5th Edition. Philadelphia, PA: Elsevier, 2018; pp.155\u2013159.","edition":"5"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(82)34746-6"},{"key":"e_1_3_3_8_2","first-page":"L567","article-title":"Phosphatidylcholine molecular species of calf lung surfactant","volume":"269","author":"Kahn M.C.","year":"1995","unstructured":"Kahn M.C., , Anderson G.J., , Anyan W.R., , and Hall S.B. Phosphatidylcholine molecular species of calf lung surfactant. Am. J. Physiol. 269:L567\u2013L573, 1995.","journal-title":"Am. J. Physiol"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2011.02.002"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2015.03.012"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.611384"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000228"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.11.5866"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/02713680701694369"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0201"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.10.033"},{"key":"e_1_3_3_17_2","first-page":"448","article-title":"Hyperbaric oxygen therapy in the treatment of secondary keratoendotheliosis","volume":"24","author":"Recupero S.M.","year":"1992","unstructured":"Recupero S.M., , Cruciani F., , Picardo V., , Sposato P.A., , Tamanti N., , and Abdolrahimzadeh S. Hyperbaric oxygen therapy in the treatment of secondary keratoendotheliosis. Ann. Ophthalmol. 24:448\u2013452, 1992.","journal-title":"Ann. Ophthalmol"},{"key":"e_1_3_3_18_2","first-page":"405","article-title":"Therapeutic efficacy of 5% NaCl hypertonic solution in patients with bullous keratopathy","volume":"30","author":"Knezovic I.","year":"2006","unstructured":"Knezovic I., , Dekaris I., , Gabric J., , Barisic A., , Bosnar D., , Rastegorac P., et al. Therapeutic efficacy of 5% NaCl hypertonic solution in patients with bullous keratopathy. Coll. Antropol. 30:405\u2013408, 2006.","journal-title":"Coll. Antropol"},{"key":"e_1_3_3_19_2","first-page":"81","article-title":"Therapeutic efficacy of 3% NaCl hypertonic solution in postoperative corneal edema","volume":"11","author":"Khripun K.V.","year":"2018","unstructured":"Khripun K.V., , Nizametdinova Yush., , and Varganova T.S. Therapeutic efficacy of 3% NaCl hypertonic solution in postoperative corneal edema. Ophthalmology Journal. 11:81\u201386, 2018.","journal-title":"Ophthalmology Journal"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000214225.98366.83"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001502"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.04.010"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)73923-6"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(03)00648-5"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(96)80121-0"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.02.013"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(99)00462-9"}],"container-title":["Journal of Ocular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jop.2020.0121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jop.2020.0121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jop.2020.0121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:44:21Z","timestamp":1777646661000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jop.2020.0121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,1]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,5,1]]}},"alternative-id":["10.1089\/jop.2020.0121"],"URL":"https:\/\/doi.org\/10.1089\/jop.2020.0121","relation":{},"ISSN":["1080-7683","1557-7732"],"issn-type":[{"value":"1080-7683","type":"print"},{"value":"1557-7732","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,1]]}}}