{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:52:33Z","timestamp":1777909953122,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the effects of a single dose of oral 5-mg tadalafil on macular microcirculation as measured using optical coherence tomography (OCT) and angiography (OCTA) in healthy volunteers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twenty-two healthy, middle-aged, sexually active, and male health care worker volunteers were included in this prospective study. All volunteers have a history of occasionally using off-label 5\u2009mg tadalafil to enhance sexual performance. Superficial and deep capillary plexus vascular densities, foveal avascular zone parameters, outer retina, and choriocapillaris flow areas were performed using the OCTA, and subfoveal-choroidal thickness (CT) was performed by using the OCT. Measurements were performed preintake, 30\u2009min, 1, 4, 24\u2009h, 2, 3, 4, and 7 days after the intake of tadalafil off-label.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Twenty-two eyes of 22 male volunteers were included in the study. The mean age was 37.16\u2009\u00b1\u20094.52 years. At 30\u2009min, 1\u2009h, and 4\u2009h after intake, a statistically significant increase was observed in the choriocapillaris flow area and CT compared with preintake (\n                      <jats:italic toggle=\"yes\">Friedman test<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.034 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study showed that a single dose of oral 5-mg tadalafil causes an increase in choriocapillaris flow and CT. To evaluate the effects of tadalafil on the retina and choroid, an OCTA assessment may be helpful.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2020.0124","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T14:23:53Z","timestamp":1624026233000},"page":"421-429","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of Retinal and Choroidal Microcirculation Alterations After a Single Dose of Oral 5-mg Tadalafil: A Prospective Pilot Optical Coherence Tomography Angiography Study"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0958-9961","authenticated-orcid":false,"given":"Mehmet Cem","family":"Sabaner","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Bafra State Hospital, Samsun, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7237-9847","authenticated-orcid":false,"given":"Mustafa","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4846-312X","authenticated-orcid":false,"given":"Muberra","family":"Akdogan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1420-4536","authenticated-orcid":false,"given":"Serdar","family":"Karadag","sequence":"additional","affiliation":[{"name":"Department of Urology, Bakirkoy Sadi Konuk Training and Research Hospital, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9028-2421","authenticated-orcid":false,"given":"Ismail Umut","family":"Onur","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bakirkoy Sadi Konuk Training and Research Hospital, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6943-6676","authenticated-orcid":false,"given":"Ali \u0130hsan","family":"Tasci","sequence":"additional","affiliation":[{"name":"Department of Urology, Bakirkoy Sadi Konuk Training and Research Hospital, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0176-1509","authenticated-orcid":false,"given":"Fadime Ulviye","family":"Yigit","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bakirkoy Sadi Konuk Training and Research Hospital, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.02.020"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2013.38"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2015.4"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702908"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2009.01627.x"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901208"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-017-1644-5"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.389189"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1250756"},{"key":"e_1_3_5_11_2","doi-asserted-by":"crossref","first-page":"7174540","DOI":"10.1155\/2017\/7174540","article-title":"Changes in retinal and choroidal vascular blood flow after oral sildenafil: an optical coherence tomography angiography study","volume":"2017","author":"Berrones D.","year":"2017","unstructured":"Berrones D., , Salcedo-Villanueva G., , Morales-Cant\u00f3n V., , and Velez-Montoya R. 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