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In addition, DMSO is used for its various therapeutic and pharmaceutical properties, such as anti-inflammatory, local and systemic analgesic, antibacterial, antifungal, antiviral, and membrane penetration enhancement agents. DMSO treatment can be given orally, intravenously, or topically for a wide range of indications. The administration of DMSO exhibits favorable outcomes in human eye diseases with low to none observed ocular or systemic ocular toxicity. Nevertheless, DMSO is an essential and nonpatentable potential therapeutic agent that remains underexplored and ignored by pharmaceutical developers and ophthalmologists. This current review takes data from experimental and clinical studies that have been published to substantiate the potential therapeutic efficacy of DMSO and stimulate the research of its application in clinical ophthalmology. Given that DMSO is inexpensive, safe, and easily formulated into therapeutic medicinal products and conventional ophthalmological drugs, this compound should be further explored and studied in the treatment of a variety of acute and chronic ocular disorders.<\/jats:p>","DOI":"10.1089\/jop.2021.0043","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T17:14:50Z","timestamp":1627406090000},"page":"441-451","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Application of Dimethyl Sulfoxide as a Therapeutic Agent and Drug Vehicle for Eye Diseases"],"prefix":"10.1177","volume":"37","author":[{"given":"Cuong","family":"Hoang","sequence":"first","affiliation":[{"name":"Department of Training and Social Relationship, National Ophthalmological Hospital, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh Kim","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Inventive Medical Foundation, South El Monte, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thai Q.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Thai Minh Pharmaceutical, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Fang","sequence":"additional","affiliation":[{"name":"Western University of Health Sciences, Pomona, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Surgery, Keck School of Medicine University of Southern California, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ba X.","family":"Hoang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Keck School of Medicine University of Southern California, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hau D.","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Oncology, National Children Hospital, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.12.040172.002033"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005298426614"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(09)70026-X"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp200743w"},{"key":"e_1_3_4_6_2","first-page":"134","article-title":"Dimethyl sulfoxide (DMSO): a new concept in","volume":"6","author":"Jacob S.W.","year":"1964","unstructured":"Jacob S.W., , Bischel M., , and Herschler R.J. 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