{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:07:29Z","timestamp":1792789649140,"version":"4.5.0"},"reference-count":322,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:p>Age-related macular degeneration (AMD) is a major leading cause of irreversible visual impairment in the world with limited therapeutic interventions. Histological, biochemical, genetic, and epidemiological studies strongly implicate dysregulated lipid metabolism in the retinal pigmented epithelium (RPE) in AMD pathobiology. However, effective therapies targeting lipid metabolism still need to be identified and developed for this blinding disease. To test lipid metabolism-targeting therapies, preclinical AMD mouse models are needed to establish therapeutic efficacy and the role of lipid metabolism in the development of AMD-like pathology. In this review, we provide a comprehensive overview of current AMD mouse models available to researchers that could be used to provide preclinical evidence supporting therapies targeting lipid metabolism for AMD. Based on previous studies of AMD mouse models, we discuss strategies to modulate lipid metabolism as well as examples of studies evaluating lipid-targeting therapeutics to restore lipid processing in the RPE. The use of AMD mouse models may lead to worthy lipid-targeting candidate therapies for clinical trials to prevent the blindness caused by AMD.<\/jats:p>","DOI":"10.1089\/jop.2021.0067","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T17:14:52Z","timestamp":1637169292000},"page":"3-32","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["Targeting Lipid Metabolism for the Treatment of Age-Related Macular Degeneration: Insights from Preclinical Mouse Models"],"prefix":"10.1177","volume":"38","author":[{"given":"Michael","family":"Landowski","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, University of Wisconsin-Madison, Madison, Wisconsin, USA."},{"name":"McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, Wisconsin, USA."},{"name":"Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Bowes Rickman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Duke University Medical Center, Durham, North Carolina, USA."},{"name":"Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70145-1"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0801537"},{"key":"e_1_3_4_4_2","first-page":"933","article-title":"Prevalence of age-related maculopathy","volume":"99","author":"Klein R.","year":"1992","unstructured":"Klein R., , Klein B.E., , and Linton K.L. Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology. 99:933\u2013943, 1992.","journal-title":"The Beaver Dam Eye Study. Ophthalmology"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)31034-2"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.10.018"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12757"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.09.041"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.11.1570"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/jovr.jovr_125_18"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S2151"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.10.018"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2015.1057565"},{"key":"e_1_3_4_14_2","first-page":"5397","article-title":"Intravitreal anti-VEGF injections for treating wet age-related macular degeneration: a systematic review and meta-analysis","volume":"9","author":"Ba J.","year":"2015","unstructured":"Ba J., , Peng R.S., , Xu D., , Li Y.H., , Shi H., , Wang Q., , and Yu J. Intravitreal anti-VEGF injections for treating wet age-related macular degeneration: a systematic review and meta-analysis. Drug Des. Devel. Ther. 9:5397\u20135405, 2015.","journal-title":"Drug Des. Devel. Ther"},{"key":"e_1_3_4_15_2","first-page":"1857","article-title":"Resistance to anti-VEGF therapy in neovascular age-related macular degeneration: a comprehensive review","volume":"10","author":"Yang S.","year":"2016","unstructured":"Yang S., , Zhao J., , and Sun X. Resistance to anti-VEGF therapy in neovascular age-related macular degeneration: a comprehensive review. Drug Des. Devel. Ther. 10:1857\u20131867, 2016.","journal-title":"Drug Des. Devel. Ther"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2016.208"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.10.1417"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000046"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-090413-025610"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2009.11.003"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1814014116"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1424391112"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.09.001"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.012305"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2014.03.002"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2018.04.006"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2018.09.023"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.TR120000979"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.06.003"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.6636"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.03.013"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1721033115"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.4.519"},{"key":"e_1_3_4_34_2","first-page":"31","article-title":"Mitochondrial dysfunction in the aging retina","volume":"8","author":"Eells J.T.","year":"2019","unstructured":"Eells J.T. Mitochondrial dysfunction in the aging retina. Biology (Basel). 8: 31, 2019.","journal-title":"Biology (Basel)"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-300344"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1994.01090150132035"},{"key":"e_1_3_4_37_2","first-page":"171","article-title":"Aging changes in Bruch's membrane","volume":"97","author":"Pauleikhoff D.","year":"1990","unstructured":"Pauleikhoff D., , Harper C.A., , Marshall J., , and Bird A.C. Aging changes in Bruch's membrane. A histochemical and morphologic study. Ophthalmology. 97:171\u2013178, 1990.","journal-title":"A histochemical and morphologic study. Ophthalmology"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00961-2"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.14.7.835"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010329"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1446"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63836-9"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.08.025"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-304226"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2007.04.002"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.222551899"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2019.100825"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2011.10.016"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2018.0504"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx189"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M073684"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.09.045"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.06.020"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1159\/000323815"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-20083"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300306-JLR200"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1109703108"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3448"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2017.06.002"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1086\/301901"},{"key":"e_1_3_4_61_2","first-page":"287","article-title":"Association of the apolipoprotein E gene with age-related macular degeneration: possible effect modification by family history, age, and gender","volume":"6","author":"Schmidt S.","year":"2000","unstructured":"Schmidt S., , Saunders A.M., , De La Paz M.A., , Postel E.A., , Heinis R.M., , Agarwal A., , Scott W.K., , Gilbert J.R., , McDowell J.G., , Bazyk A., , Gass J.D., , Haines J.L., , and Pericak-Vance M.A. Association of the apolipoprotein E gene with age-related macular degeneration: possible effect modification by family history, age, and gender. Mol. Vis. 6:287\u2013293, 2000.","journal-title":"Mol. Vis"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-1253"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21577"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912702107"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912019107"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep15711"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.45100"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.179283"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/413150"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13763"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13420"},{"key":"e_1_3_4_72_2","first-page":"1518","article-title":"Smoking and age-related maculopathy","volume":"114","author":"Smith W.","year":"1996","unstructured":"Smith W., , Mitchell P., , and Leeder S.R. Smoking and age-related maculopathy. The Blue Mountains Eye Study. Arch Ophthalmol. 114:1518\u20131523, 1996.","journal-title":"The Blue Mountains Eye Study. Arch Ophthalmol"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100140393005"},{"key":"e_1_3_4_74_2","first-page":"171","article-title":"Overview of risk factors for age-related macular degeneration (AMD)","volume":"10","author":"Armstrong R.A.","year":"2015","unstructured":"Armstrong R.A., , and Mousavi M. Overview of risk factors for age-related macular degeneration (AMD). J. Stem Cells. 10:171\u2013191, 2015.","journal-title":"J. Stem Cells"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.10.047"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370110106"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036198"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2009.01.017"},{"key":"e_1_3_4_79_2","first-page":"1891","article-title":"Effects of cholesterol and apolipoprotein E on retinal abnormalities in ApoE-deficient mice","volume":"42","author":"Ong J.M.","year":"2001","unstructured":"Ong J.M., , Zorapapel N.C., , Rich K.A., , Wagstaff R.E., , Lambert R.W., , Rosenberg S.E., , Moghaddas F., , Pirouzmanesh A., , Aoki A.M., , and Kenney M.C. Effects of cholesterol and apolipoprotein E on retinal abnormalities in ApoE-deficient mice. Invest. Ophthalmol. Vis. Sci. 42:1891\u20131900, 2001.","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M090043"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503015102"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100901108"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-11636"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15166"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.032698"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.2.209"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.8.1191"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.12.1728"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.7.995"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14715-z"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn167"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20919"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.19"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4239-09.2010"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2007.03.023"},{"key":"e_1_3_4_96_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-4184-5"},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12447"},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.1006\/exer.2000.0835"},{"key":"e_1_3_4_99_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-014-9546-7"},{"key":"e_1_3_4_100_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2007.00351.x"},{"key":"e_1_3_4_101_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.131928"},{"key":"e_1_3_4_102_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15195"},{"key":"e_1_3_4_103_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1307574110"},{"key":"e_1_3_4_104_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1702302114"},{"key":"e_1_3_4_105_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8545"},{"key":"e_1_3_4_106_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1709"},{"key":"e_1_3_4_107_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1472"},{"key":"e_1_3_4_108_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405146101"},{"key":"e_1_3_4_109_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705079104"},{"key":"e_1_3_4_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.08.026"},{"key":"e_1_3_4_111_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4457"},{"key":"e_1_3_4_112_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01903"},{"key":"e_1_3_4_113_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-020-00491-4"},{"key":"e_1_3_4_114_2","doi-asserted-by":"crossref","first-page":"e0173716","DOI":"10.1371\/journal.pone.0173716","article-title":"Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice","volume":"12","author":"Huang H.","year":"2017","unstructured":"Huang H., , Liu Y., , Wang L., , and Li W. Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice. PLoS One. 12:e0173716, 2017.","journal-title":"PLoS One"},{"key":"e_1_3_4_115_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1906643116"},{"key":"e_1_3_4_116_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070730"},{"key":"e_1_3_4_117_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602131103"},{"key":"e_1_3_4_118_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0432"},{"key":"e_1_3_4_119_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14633"},{"key":"e_1_3_4_120_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14453"},{"key":"e_1_3_4_121_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1909761117"},{"key":"e_1_3_4_122_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.12.16"},{"key":"e_1_3_4_123_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2000339117"},{"key":"e_1_3_4_124_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101031"},{"key":"e_1_3_4_125_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2016.03.021"},{"key":"e_1_3_4_126_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2898"},{"key":"e_1_3_4_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2005.08.002"},{"key":"e_1_3_4_128_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.135"},{"key":"e_1_3_4_129_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102853108"},{"key":"e_1_3_4_130_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022959"},{"key":"e_1_3_4_131_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2103617118"},{"key":"e_1_3_4_132_2","doi-asserted-by":"crossref","first-page":"e0133032","DOI":"10.1371\/journal.pone.0133032","article-title":"Lack of acid sphingomyelinase induces age-related retinal degeneration","volume":"10","author":"Wu B.X.","year":"2015","unstructured":"Wu B.X., , Fan J., , Boyer N.P., , Jenkins R.W., , Koutalos Y., , Hannun Y.A., , and Crosson C.E. Lack of acid sphingomyelinase induces age-related retinal degeneration. PLoS One. 10:e0133032, 2015.","journal-title":"PLoS One"},{"key":"e_1_3_4_133_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003119"},{"key":"e_1_3_4_134_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2717"},{"key":"e_1_3_4_135_2","first-page":"503725","article-title":"Infiltration of proinflammatory m1 macrophages into the outer retina precedes damage in a mouse model of age-related macular degeneration","volume":"2013","author":"Cruz-Guilloty F.","year":"2013","unstructured":"Cruz-Guilloty F., , Saeed A.M., , Echegaray J.J., , Duffort S., , Ballmick A., , Tan Y., , Betancourt M., , Viteri E., , Ramkhellawan G.C., , Ewald E., , Feuer W., , Huang D., , Wen R., , Hong L., , Wang H., , Laird J.M., , Sene A., , Apte R.S., , Salomon R.G., , Hollyfield J.G., , and Perez V.L. Infiltration of proinflammatory m1 macrophages into the outer retina precedes damage in a mouse model of age-related macular degeneration. Int. J. Inflam. 2013:503725, 2013.","journal-title":"Int. J. Inflam"},{"key":"e_1_3_4_136_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.14.11"},{"key":"e_1_3_4_137_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6207"},{"key":"e_1_3_4_138_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080927"},{"key":"e_1_3_4_139_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-23134"},{"key":"e_1_3_4_140_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012060570"},{"key":"e_1_3_4_141_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-24133"},{"key":"e_1_3_4_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2020.108061"},{"key":"e_1_3_4_143_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00351"},{"key":"e_1_3_4_144_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.09.011"},{"key":"e_1_3_4_145_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1041699"},{"key":"e_1_3_4_146_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20683"},{"key":"e_1_3_4_147_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.01.015"},{"key":"e_1_3_4_148_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.4433"},{"key":"e_1_3_4_149_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31692"},{"key":"e_1_3_4_150_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.3.338"},{"key":"e_1_3_4_151_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.204701"},{"key":"e_1_3_4_152_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.6.795"},{"key":"e_1_3_4_153_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.036"},{"key":"e_1_3_4_154_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09830"},{"key":"e_1_3_4_155_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902593106"},{"key":"e_1_3_4_156_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-21255"},{"key":"e_1_3_4_157_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43906-z"},{"key":"e_1_3_4_158_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep20636"},{"key":"e_1_3_4_159_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.303"},{"key":"e_1_3_4_160_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2004.05.002"},{"key":"e_1_3_4_161_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-080-9_6"},{"key":"e_1_3_4_162_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.09.032"},{"key":"e_1_3_4_163_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-0719"},{"key":"e_1_3_4_164_2","first-page":"675","article-title":"Retinal compensatory changes after light damage in albino mice","volume":"18","author":"Montalb\u00e1n-Soler L.","year":"2012","unstructured":"Montalb\u00e1n-Soler L., , Alarc\u00f3n-Mart\u00ednez L., , Jim\u00e9nez-L\u00f3pez M., , Salinas-Navarro M., , Galindo-Romero C., , Bezerra de S\u00e1 F., , Garc\u00eda-Ayuso D., , Avil\u00e9s-Trigueros M., , Vidal-Sanz M., , Agudo-Barriuso M., , and Villegas-P\u00e9rez M.P. Retinal compensatory changes after light damage in albino mice. Mol. Vis. 18:675\u2013693, 2012.","journal-title":"Mol. Vis"},{"key":"e_1_3_4_165_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.191866"},{"key":"e_1_3_4_166_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69076"},{"key":"e_1_3_4_167_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80602-9"},{"key":"e_1_3_4_168_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-11688"},{"key":"e_1_3_4_169_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr080"},{"key":"e_1_3_4_170_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17166"},{"key":"e_1_3_4_171_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt395"},{"key":"e_1_3_4_172_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv287"},{"key":"e_1_3_4_173_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm198"},{"key":"e_1_3_4_174_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm199"},{"key":"e_1_3_4_175_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13198"},{"key":"e_1_3_4_176_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407698102"},{"key":"e_1_3_4_177_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0353"},{"key":"e_1_3_4_178_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.013763"},{"key":"e_1_3_4_179_2","first-page":"2732","article-title":"A mouse model for Sorsby fundus dystrophy","volume":"43","author":"Weber B.H.","year":"2002","unstructured":"Weber B.H., , Lin B., , White K., , Kohler K., , Soboleva G., , Herterich S., , Seeliger M.W., , Jaissle G.B., , Grimm C., , Reme C., , Wenzel A., , Asan E., , and Schrewe H. A mouse model for Sorsby fundus dystrophy. Invest. Ophthalmol. Vis. Sci. 43:2732\u20132740, 2002.","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"e_1_3_4_180_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2010.05.003"},{"key":"e_1_3_4_181_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15067"},{"key":"e_1_3_4_182_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1401191111"},{"key":"e_1_3_4_183_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196037"},{"key":"e_1_3_4_184_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21796"},{"key":"e_1_3_4_185_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1148"},{"key":"e_1_3_4_186_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-1113-z"},{"key":"e_1_3_4_187_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010112"},{"key":"e_1_3_4_188_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.09.036"},{"key":"e_1_3_4_189_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu7075229"},{"key":"e_1_3_4_190_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1085"},{"key":"e_1_3_4_191_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-0855"},{"key":"e_1_3_4_192_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.307558"},{"key":"e_1_3_4_193_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg289"},{"key":"e_1_3_4_194_2","doi-asserted-by":"publisher","DOI":"10.1038\/9722"},{"key":"e_1_3_4_195_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1294-352"},{"key":"e_1_3_4_196_2","doi-asserted-by":"publisher","DOI":"10.1038\/83817"},{"key":"e_1_3_4_197_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5333.1805"},{"key":"e_1_3_4_198_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3944"},{"key":"e_1_3_4_199_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M900322200"},{"key":"e_1_3_4_200_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-9662"},{"key":"e_1_3_4_201_2","doi-asserted-by":"publisher","DOI":"10.1038\/347677a0"},{"key":"e_1_3_4_202_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.7.2955"},{"key":"e_1_3_4_203_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.11.040"},{"key":"e_1_3_4_204_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.035360"},{"key":"e_1_3_4_205_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2017.10.029"},{"key":"e_1_3_4_206_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125631"},{"key":"e_1_3_4_207_2","first-page":"1236","article-title":"Photoreceptor loss in age-related macular degeneration","volume":"37","author":"Curcio C.A.","year":"1996","unstructured":"Curcio C.A., , Medeiros N.E., , and Millican C.L. Photoreceptor loss in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 37:1236\u20131249, 1996.","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"e_1_3_4_208_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.07.002"},{"key":"e_1_3_4_209_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2001776117"},{"key":"e_1_3_4_210_2","first-page":"4376","article-title":"Transcriptome analysis reveals rod\/cone photoreceptor specific signatures across mammalian retinas","volume":"25","author":"Mustafi D.","year":"2016","unstructured":"Mustafi D., , Kevany B.M., , Bai X., , Golczak M., , Adams M.D., , Wynshaw-Boris A., , and Palczewski K. Transcriptome analysis reveals rod\/cone photoreceptor specific signatures across mammalian retinas. Hum. Mol. Genet. 25:4376\u20134388, 2016.","journal-title":"Hum. Mol. Genet"},{"key":"e_1_3_4_211_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100846"},{"key":"e_1_3_4_212_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141597"},{"key":"e_1_3_4_213_2","first-page":"S39","article-title":"Of mice and men","volume":"6","author":"Demetrius L.","year":"2005","unstructured":"Demetrius L. Of mice and men. When it comes to studying ageing and the means to slow it down, mice are not just small humans. EMBO Rep. 6 Spec No:S39\u2013S44, 2005.","journal-title":"When it comes to studying ageing and the means to slow it down, mice are not just small humans"},{"key":"e_1_3_4_214_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.28899"},{"key":"e_1_3_4_215_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037926"},{"key":"e_1_3_4_216_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M053439"},{"key":"e_1_3_4_217_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-4959(03)00046-0"},{"key":"e_1_3_4_218_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R027011"},{"key":"e_1_3_4_219_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b00213"},{"key":"e_1_3_4_220_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.11.2499"},{"key":"e_1_3_4_221_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2014.01.015"},{"key":"e_1_3_4_222_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2019.04.012"},{"key":"e_1_3_4_223_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2014.05.003"},{"key":"e_1_3_4_224_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.667880"},{"key":"e_1_3_4_225_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019456"},{"key":"e_1_3_4_226_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2018.03.001"},{"key":"e_1_3_4_227_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110189"},{"key":"e_1_3_4_228_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110359"},{"key":"e_1_3_4_229_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501536102"},{"key":"e_1_3_4_230_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1109557"},{"key":"e_1_3_4_231_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.149.8.2592"},{"key":"e_1_3_4_232_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.20.10996"},{"key":"e_1_3_4_233_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng912"},{"key":"e_1_3_4_234_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306022200"},{"key":"e_1_3_4_235_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.04.008"},{"key":"e_1_3_4_236_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10385"},{"key":"e_1_3_4_237_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2376"},{"key":"e_1_3_4_238_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M400428-JLR200"},{"key":"e_1_3_4_239_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M087361"},{"key":"e_1_3_4_240_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.08.103"},{"key":"e_1_3_4_241_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903596"},{"key":"e_1_3_4_242_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25786"},{"key":"e_1_3_4_243_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2007.10.009"},{"key":"e_1_3_4_244_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-018-0037-x"},{"key":"e_1_3_4_245_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000143422.83209.be"},{"key":"e_1_3_4_246_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.02.014"},{"key":"e_1_3_4_247_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.13.6393"},{"key":"e_1_3_4_248_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0003-4"},{"key":"e_1_3_4_249_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.36184"},{"key":"e_1_3_4_250_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115764"},{"key":"e_1_3_4_251_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202974"},{"key":"e_1_3_4_252_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021115-105045"},{"key":"e_1_3_4_253_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(02)01369-X"},{"key":"e_1_3_4_254_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2012.05.013"},{"key":"e_1_3_4_255_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2013.37"},{"key":"e_1_3_4_256_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44303"},{"key":"e_1_3_4_257_2","first-page":"1","article-title":"Loss of PGC-1\u03b1 in RPE induces mesenchymal transition and promotes retinal degeneration","volume":"2","author":"Rosales M.A.B.","year":"2019","unstructured":"Rosales M.A.B., , Shu D.Y., , Iacovelli J., , and Saint-Geniez M. Loss of PGC-1\u03b1 in RPE induces mesenchymal transition and promotes retinal degeneration. Life Sci. Alliance. 2:1\u201317, 2019.","journal-title":"Life Sci. Alliance"},{"key":"e_1_3_4_258_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0199-y"},{"key":"e_1_3_4_259_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.26281"},{"key":"e_1_3_4_260_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-75402-4_61"},{"key":"e_1_3_4_261_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1198-1"},{"key":"e_1_3_4_262_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI79766"},{"key":"e_1_3_4_263_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2234"},{"key":"e_1_3_4_264_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2014.11.005"},{"key":"e_1_3_4_265_2","doi-asserted-by":"publisher","DOI":"10.4161\/15384101.2014.991572"},{"key":"e_1_3_4_266_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.19-27512"},{"key":"e_1_3_4_267_2","doi-asserted-by":"publisher","DOI":"10.1038\/77004"},{"key":"e_1_3_4_268_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.15.10303"},{"key":"e_1_3_4_269_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0997-15"},{"key":"e_1_3_4_270_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-5635-4_8"},{"key":"e_1_3_4_271_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708714104"},{"key":"e_1_3_4_272_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.130110497"},{"key":"e_1_3_4_273_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17402-1"},{"key":"e_1_3_4_274_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2009.09.006"},{"key":"e_1_3_4_275_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1805039115"},{"key":"e_1_3_4_276_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-3209-8_57"},{"key":"e_1_3_4_277_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217251110"},{"key":"e_1_3_4_278_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M021386"},{"key":"e_1_3_4_279_2","doi-asserted-by":"publisher","DOI":"10.1080\/13816810.2018.1430240"},{"key":"e_1_3_4_280_2","first-page":"1185","article-title":"DHA does not protect ELOVL4 transgenic mice from retinal degeneration","volume":"15","author":"Li F.","year":"2009","unstructured":"Li F., , Marchette L.D., , Brush R.S., , Elliott M.H., , Le Y.Z., , Henry K.A., , Anderson A.G., , Zhao C., , Sun X., , Zhang K., , and Anderson R.E. DHA does not protect ELOVL4 transgenic mice from retinal degeneration. Mol. Vis. 15:1185\u20131193, 2009.","journal-title":"Mol. Vis"},{"key":"e_1_3_4_281_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8569"},{"key":"e_1_3_4_282_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.256073"},{"key":"e_1_3_4_283_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.4997"},{"key":"e_1_3_4_284_2","first-page":"8","article-title":"High-density lipoprotein cholesterol and cardiovascular disease","volume":"79","author":"Gordon D.J.","year":"1989","unstructured":"Gordon D.J., , Probstfield J.L., , Garrison R.J., , Neaton J.D., , Castelli W.P., , Knoke J.D., , Jacobs D.R., , Bangdiwala S., , and Tyroler H.A. High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation. 79:8\u201315, 1989.","journal-title":"Four prospective American studies. Circulation"},{"key":"e_1_3_4_285_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300133"},{"key":"e_1_3_4_286_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.187518"},{"key":"e_1_3_4_287_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M011098"},{"key":"e_1_3_4_288_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2020.08.004"},{"key":"e_1_3_4_289_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu171"},{"key":"e_1_3_4_290_2","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12487"},{"key":"e_1_3_4_291_2","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2017.1370118"},{"key":"e_1_3_4_292_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194807"},{"key":"e_1_3_4_293_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08702-7"},{"key":"e_1_3_4_294_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.03.012"},{"key":"e_1_3_4_295_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161209787315684"},{"key":"e_1_3_4_296_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083759"},{"key":"e_1_3_4_297_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.01.033"},{"key":"e_1_3_4_298_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.8"},{"key":"e_1_3_4_299_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.10.027"},{"key":"e_1_3_4_300_2","first-page":"615","article-title":"Statin and aspirin therapy are associated with decreased rates of choroidal neovascularization among patients with age-related macular degeneration","volume":"137","author":"Wilson H.L.","year":"2004","unstructured":"Wilson H.L., , Schwartz D.M., , Bhatt H.R., , McCulloch C.E., , and Duncan J.L. Statin and aspirin therapy are associated with decreased rates of choroidal neovascularization among patients with age-related macular degeneration. Am. J. Ophthalmol. 137:615\u2013624, 2004.","journal-title":"Am. J. Ophthalmol"},{"key":"e_1_3_4_301_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0195-z"},{"key":"e_1_3_4_302_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318276e0cf"},{"key":"e_1_3_4_303_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2019.60.7.679"},{"key":"e_1_3_4_304_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.08.028"},{"key":"e_1_3_4_305_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00309"},{"key":"e_1_3_4_306_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.05.027"},{"key":"e_1_3_4_307_2","doi-asserted-by":"publisher","DOI":"10.3109\/09286586.2011.560746"},{"key":"e_1_3_4_308_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.12.037"},{"key":"e_1_3_4_309_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.06.055"},{"key":"e_1_3_4_310_2","doi-asserted-by":"publisher","DOI":"10.1080\/02713680902741670"},{"key":"e_1_3_4_311_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.02.047"},{"key":"e_1_3_4_312_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.11.021"},{"key":"e_1_3_4_313_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.1.33"},{"key":"e_1_3_4_314_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.064477"},{"key":"e_1_3_4_315_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.8.1151"},{"key":"e_1_3_4_316_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.118.083345"},{"key":"e_1_3_4_317_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.109.2.387"},{"key":"e_1_3_4_318_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05211.x"},{"key":"e_1_3_4_319_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2010.537427"},{"key":"e_1_3_4_320_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.4128"},{"key":"e_1_3_4_321_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18663"},{"key":"e_1_3_4_322_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.10.028"},{"key":"e_1_3_4_323_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2014.927507"}],"container-title":["Journal of Ocular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jop.2021.0067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jop.2021.0067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jop.2021.0067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:44:41Z","timestamp":1777646681000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jop.2021.0067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,1]]},"references-count":322,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1,1]]}},"alternative-id":["10.1089\/jop.2021.0067"],"URL":"https:\/\/doi.org\/10.1089\/jop.2021.0067","relation":{},"ISSN":["1080-7683","1557-7732"],"issn-type":[{"value":"1080-7683","type":"print"},{"value":"1557-7732","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,1]]}}}