{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T23:09:00Z","timestamp":1783552140979,"version":"3.55.0"},"reference-count":68,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the effect of reducing blood pressure (BP) by atenolol and amlodipine on (1) intraocular pressure (IOP) and (2) ophthalmic artery blood flow (OAF) velocity in new hypertensives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A prospective, observational cohort study conducted at a tertiary care center in India after IRB approval. New hypertensives treated with atenolol 25\u2009mg or amlodipine 5\u2009mg were divided into 2 groups of 30 patients each. BP, IOP by Goldmann applanation tonometry and OAF velocity by transcranial doppler sonography was performed before medication and post medication on day 1, 7, and 30.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There was a significant decrease in IOP with both drugs; the effect was greater with atenolol. Atenolol: premedication IOP - 16.06\u2009\u00b1\u20092.13\u2009mmHg and day 30\u201312.46\u2009\u00b1\u20091.94 (22.4%) [\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001], amlodipine: premedication IOP-15.13\u2009\u00b1\u20092.55\u2009mmHg and day 30- 13.06\u2009\u00b1\u20092.14 (13.68%) [\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001]. A decrease of 0.5\u2009mmHg in IOP with every 10\u2009mmHg (95% CI: 0.121\u20130.826,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value\u2009=\u20090.01) decrease in systolic BP was noted after oral atenolol. The OAF peak systolic velocity and mean flow velocity were equally reduced with both drugs (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001). The end-diastolic velocity, reduced only with atenolol (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.049) but returned to baseline with amlodipine at 1 month.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>BP reduction by atenolol and amlodipine led to decreases in IOP and OAF velocity, greater with atenolol. The IOP decrease was likely due to reduced blood flow. A slight decrease in the diastolic flow of the ophthalmic artery was noted with atenolol.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2021.0096","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T09:26:02Z","timestamp":1640769962000},"page":"148-155","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Blood Pressure Reduction on Intraocular Pressure and Ophthalmic Artery Blood Flow Velocity in Hypertension"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0893-9090","authenticated-orcid":false,"given":"Geeta","family":"Behera","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Jawaharlal Institute of Post-Graduate Medical Education and Research (JIPMER), Puducherry, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gururaj Alur","family":"Nagaraj","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Indira Gandhi Government General Hospital and Post Graduate Institute (IGGGH&amp;PGI), Puducherry, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh Chidambaram","family":"Thirunavukarasu","sequence":"additional","affiliation":[{"name":"Department of Neurology, and Indira Gandhi Government General Hospital and Post Graduate Institute (IGGGH&amp;PGI), Puducherry, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Jayaraman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Indira Gandhi Government General Hospital and Post Graduate Institute (IGGGH&amp;PGI), Puducherry, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeswari","family":"Murugesan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Jawaharlal Institute of Post-Graduate Medical Education and Research (JIPMER), Puducherry, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anandaraja","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Indira Gandhi Government General Hospital and Post Graduate Institute (IGGGH&amp;PGI), Puducherry, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(02)00008-3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12298"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00919280"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70067-4"},{"key":"e_1_3_3_6_2","first-page":"54","article-title":"Primary open-angle glaucoma, intraocular pressure, and systemic blood pressure in the general elderly population","volume":"102","author":"Dielemans I.","year":"1995","unstructured":"Dielemans I., , Vingerling J.R., , Algra D., , Hofman A., , Grobbee D.E., , and de Jong P.T. 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