{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:53:00Z","timestamp":1777909980357,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To identify 24-h changes in ocular biometric parameters in subjects with ocular hypertension (OHT), and to determine if an intraocular pressure (IOP)-lowering drug alters these parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Thirty volunteers with OHT (58.6\u2009\u00b1\u20099.2 years of age) were enrolled in this randomized, double-masked, placebo-controlled, crossover study. Participants self-administered 0.2% brimonidine or placebo 3 times daily for 6 weeks. Measurements of seated and supine IOP, central cornea thickness (CCT), anterior chamber depth (ACD), axial length (AXL), and lens thickness were made at 8 am, 3 pm, 8 pm, and 3 am. Statistical tests were Student's 2-tailed paired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -tests or 2-way analysis of variance (ANOVA) followed by one-way ANOVA and post hoc testing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Time of day had a significant effect on IOP, CCT, ACD, and AXL. In placebo-treated eyes, CCT was greater at 3 am than at any other time (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.01), ACD and AXL were greater at 3 am and 8 pm than at 3 pm (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.01). Daytime IOPs were higher than nighttime (seated,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.007; supine,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.018), and supine IOP at night was higher than seated IOP during the day (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Brimonidine did not lower IOP at night nor did it alter the 24-h patterns of CCT, ACD, and AXL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Ocular biometric parameters exhibit characteristic 24-h fluctuations in patients with OHT. At night compared with day, the supine IOP increases, the cornea thickens, the anterior chamber deepens, and the AXL increases. Brimonidine does not alter these parameters at times when it lowers IOP (day) nor when it does not (night). Clinical Trial Registration number: NCT0132419.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2021.0132","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T09:46:27Z","timestamp":1658310387000},"page":"489-495","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Changes in Ocular Biometric Parameters Over a 24-Hour Period in Ocular Hypertensive Patients"],"prefix":"10.1177","volume":"38","author":[{"given":"Shan","family":"Fan","sequence":"first","affiliation":[{"name":"Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Gulati","sequence":"additional","affiliation":[{"name":"Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna G.","family":"Neely","sequence":"additional","affiliation":[{"name":"Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austin","family":"Andersen","sequence":"additional","affiliation":[{"name":"Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3794-6142","authenticated-orcid":false,"given":"Carol B.","family":"Toris","sequence":"additional","affiliation":[{"name":"Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA."},{"name":"Department of Ophthalmology and Visual Science, The Ohio State University, Omaha, Nebraska, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e32834cd63e"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.80.12.1068"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31814b9922"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25389"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12633"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10709"},{"issue":"13","key":"e_1_3_4_8_2","first-page":"2796","volume":"39","author":"Liu JH","year":"1998","unstructured":"Liu JH, , Farid H. 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