{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T02:15:45Z","timestamp":1781230545161,"version":"3.54.1"},"reference-count":35,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the longitudinal changes of axial length (AL) and factors associated with AL growth in myopic children receiving 0.05% atropine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This single-center retrospective study included children aged 4\u201313 years with myopia of at least \u22120.5 diopters (D) treated with 0.05% atropine eye drops from November 2016 to May 2021. Predictive factors for AL change were evaluated using linear mixed models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 109 patients (218 eyes), 58 (53.2%) were male and the mean age at treatment was 8.5\u2009\u00b1\u20092.0 years. At baseline measurement, the mean spherical equivalent was \u22124.05\u2009\u00b1\u20092.34 diopters (D), and AL was 25.00\u2009\u00b1\u20090.97\u2009mm. The mean follow-up duration was 25.4 (12\u201358) months, and the mean AL elongation was 0.23\u2009\u00b1\u20090.17\u2009mm\/year during the follow-up periods. AL shortening of \u22650.05\u2009mm at subsequent visit occurred in 18 patients (26 eyes). The mean AL change in the group without initial AL shortening was statistically larger than that in the group with initial AL shortening (0.26\u2009\u00b1\u20090.16\u2009mm\/year vs. 0.02\u2009\u00b1\u20090.17\u2009mm\/year,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001). In linear mixed model, the age at atropine treatment and initial AL shortening were significantly associated with respect to AL growth (beta coefficient: \u22120.032 and \u22120.122, respectively,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001 for both).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our study found that older age and initial AL shortening are predictors of favorable response after 0.05% atropine treatment. Children with AL shortening at initial subsequent visit may be associated with good long-term response, and younger children may require higher concentration of atropine for optimal response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2022.0036","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T12:41:12Z","timestamp":1666356072000},"page":"703-708","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Factors Related to Axial Length Elongation in Myopic Children Who Received 0.05% Atropine Treatment"],"prefix":"10.1177","volume":"38","author":[{"given":"Hyuna","family":"Cho","sequence":"first","affiliation":[{"name":"Institute of Vision Research, Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Seo","sequence":"additional","affiliation":[{"name":"Institute of Vision Research, Department of Ophthalmology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sueng-Han","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Vision Research, Department of Ophthalmology, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8607-6625","authenticated-orcid":false,"given":"Jinu","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Vision Research, Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000499"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-019-1220-0"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1313.2011.00884.x"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.4.49"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-314101"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.12.019"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12346"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2020.6239"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/diseases6040092"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/09273972.2017.1421675"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.05.062"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.05.029"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0139-7"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/APO.0000000000000256"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.07.031"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.01.029"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.12.036"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01081"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19971030)16:20<2349::AID-SIM667>3.0.CO;2-E"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-021-05254-5"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-96414-4"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69710-8"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.06.004"},{"key":"e_1_3_6_25_2","first-page":"1","article-title":"Change and recovery of choroid thickness after short-term application of 1% atropine gel and its influencing factors in 6-7-year-old children","author":"Jiang Y","year":"2021","unstructured":"Jiang Y, , Zhang Z, , Wu Z, et al. 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