{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:53:12Z","timestamp":1777909992795,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Regression of the refractive outcome is a major concern of LASIK procedures mainly in presbyopic patients. The purpose of this study was to evaluate the long-term efficacy of the pharmacological treatment of presbyopia performed with Benozzi's method, in combination with hyperopic LASIK surgery in presbyopic population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A nonrandomized case series was developed, including presbyopic patients who underwent bilateral \u201cHyperopic LASIK surgery\u201d and were pharmacologically treated with Benozzi's Method from January 2011 to August 2018, with at least 2 years of follow-up, at two private ophthalmological clinics of Argentina. Main outcomes were spherical equivalent (SE), uncorrected distance visual acuity (UDVA), and uncorrected near visual acuity (UNVA).<\/jats:p>\n                    <jats:p>Measurements were evaluated at baseline and postoperative at 1 month (without Benozzi's treatment), 2 months (starting with Benozzi's treatment), and 2 years. The SE stability across the time was statistically compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 84 eyes of 42 patients, with a mean age at the time of the surgery of 51.07\u2009\u00b1\u20094.5 (42\u201359), were found following 2 years of follow-up. Patients have improved and maintained UDVA, achieving Jaeger 1 in the second postoperative month, which was maintained up to the last year of follow-up. Refractive stability across the time is observed comparing first month after surgery with the last year of follow-up, without statistical significant difference (p: 0.11).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Hyperopic presbyopic patients that underwent LASIK surgery and 1 month after surgery started with the pharmacological treatment of presbyopia (Benozzi's method) results in excellent UNVA and UDVA that is stable over time without refractive regression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2022.0095","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T17:18:55Z","timestamp":1667323135000},"page":"48-54","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Hyperopic LASIK Enhanced by Pharmacological Treatment of Presbyopia"],"prefix":"10.1177","volume":"39","author":[{"given":"Mart\u00edn Eugenio","family":"Cortina","sequence":"first","affiliation":[{"name":"Instituto Oftalmol\u00f3gico Cortina, Santa Rosa, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Benozzi","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Avanzada Para la Presbicia, Buenos Aires, Argentina."},{"name":"C\u00e1tedra de Farmacolog\u00eda, Facultad de Odontolog\u00eda, Universidad de Buenos Aires, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4584-4739","authenticated-orcid":false,"given":"Betina","family":"Orman","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Farmacolog\u00eda, Facultad de Odontolog\u00eda, Universidad de Buenos Aires, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.09.019"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20150928-06"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.13315"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-021-00346-1"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20180726-02"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_32_20"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000162"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20200618-01"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(01)00981-6"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S99098"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20180228-02"},{"issue":"1","key":"e_1_3_5_13_2","first-page":"3","article-title":"Presbyopia: A new potential pharmacological treatment","volume":"1","author":"Benozzi J","year":"2012","unstructured":"Benozzi J, , Benozzi G, , Orman B. 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