{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:15:26Z","timestamp":1792790126155,"version":"4.5.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Prostaglandin-associated periorbitopathy in patients with glaucoma is reportedly not caused by EP2 agonist, but it has been a cosmetic problem with prostaglandin F receptor (FP) agonists. In this study, patients with prostaglandin-associated periorbitopathy on FP agonists were switched to EP2 agonist and changes were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients complaining of prostaglandin-associated periorbitopathy were included. The FP agonist was switched to EP2 agonist (omidenepag isopropyl), and patients were followed up for 7 months. Frontal photographs were taken at every visit, and objective changes in deepening of the upper eyelid sulcus were assessed by three observers. Subjective questionnaires (self-awareness of deepening of the upper eyelid sulcus, eyelid\/peri-eyelid skin pigmentation, eyelash elongation, and conjunctival hyperemia) were acquired at the start and the endpoint. Factors associated with the change of prostaglandin-associated periorbitopathy were investigated using logistic regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Included were 23 eyes of 23 patients (17 women; 60.6 years). At 7 months, objective deepening of the upper eyelid sulcus improved by 76%. The subjective questionnaires showed that deepening of the upper eyelid sulcus improved in 95%, eyelid\/peri-eyelid skin pigmentation in 76%. The less extent of myopia was a significant factor in the eyes with improved eyelid\/peri-eyelid skin pigmentation. After switching, no change in intraocular pressure or visual acuity was observed (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009\u2265\u20090.22).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Switching to omidenepag isopropyl increased patient satisfaction and might be the first step to lightening deepening of the upper eyelid sulcus and eyelid\/peri-eyelid skin pigmentation. It was suggested that pigmentation may be more easily improved in nonmyopic eyes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2022.0096","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T12:56:58Z","timestamp":1667307418000},"page":"63-69","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Prostaglandin-Associated Periorbitopathy Symptom Alleviation After Switching Prostaglandin F Receptor Agonist to EP2 Receptor Agonist in Patients with Glaucoma"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1411-1476","authenticated-orcid":false,"given":"Rei","family":"Sakata","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Graduate of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan."},{"name":"Yotsuya Shirato Eye Clinic, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Fujishiro","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Graduate of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan."},{"name":"Yotsuya Shirato Eye Clinic, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Graduate of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan."},{"name":"Yotsuya Shirato Eye Clinic, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Graduate of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan."},{"name":"Yotsuya Shirato Eye Clinic, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Honjo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Graduate of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan."},{"name":"Yotsuya Shirato Eye Clinic, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiroaki","family":"Shirato","sequence":"additional","affiliation":[{"name":"Yotsuya Shirato Eye Clinic, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuyo","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Santen Pharmaceutical Co., Ltd., Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Yamada","sequence":"additional","affiliation":[{"name":"Santen Pharmaceutical Co., Ltd., Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Aihara","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Graduate of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan."},{"name":"Yotsuya Shirato Eye Clinic, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3192"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-021-00844-6"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014548569"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2008.08.004"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12163"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/08820538.2021.2003824"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.224"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-011-0075-6"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-010-0904-z"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/01676830.2010.527028"},{"issue":"5","key":"e_1_3_7_12_2","first-page":"472","article-title":"Bimatoprost-induced chemical blepharoplasty","volume":"14","author":"Sarnoff DS","year":"2015","unstructured":"Sarnoff DS, , Gotkin RH. 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