{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:10:46Z","timestamp":1787008246768,"version":"build-2736575974"},"reference-count":30,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Prostaglandin (PG) receptor agonists are the first-line eyedrop medication treatment for glaucoma. The pathophysiology of this disease is not completely known, and elevated intraocular pressure (IOP) is the key risk factor. The membranes of the axons (of the retinal ganglion cells) passing through the optic nerve (ON) head experience significant damage. Lipids are an essential component of the cell's membranes, and their profile changes owing to neurodegeneration. In this investigation, three agonists for distinct PG receptors were used to lower IOP and to determine their effect on the ON lipids. We utilized DBA\/2J mice as a model of progressive IOP increase and C57BL\/6J mice as a model of ON crush.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>DBA\/2J and C57BL\/6J mice were treated daily for 2 weeks with Latanoprost, PF-04217329, or Rivenprost. The IOP was measured every 2 days and pattern electroretinogram was conducted for DBA\/2J throughout the study. Lipidomics of ONs were performed for each model and treatment group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the tested compounds, Latanoprost and Rivenprost were the most effective agents decreasing IOP in DBA\/2J mice. Triglyceride levels increased in the ONs of DBA\/2J mouse model, but phosphatidylethanolamine levels underwent highest level changes in the C57BL\/6J mouse model when treated with Latanoprost.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Topical ocular FP- and EP4-receptor agonists appreciably lowered IOP in the DBA\/2J mice representing pigmentary glaucoma. The observed changes in ON lipidomics in the different models of neurodegeneration suggest possible use of such measures in the development of more effective medicines for both IOP reduction and ON protection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2023.0006","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T13:18:06Z","timestamp":1685711886000},"page":"541-550","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Ocular Treatments Targeting Separate Prostaglandin Receptors in Mice Exhibit Alterations in Intraocular Pressure and Optic Nerve Lipidome"],"prefix":"10.1177","volume":"39","author":[{"given":"Jennifer","family":"Arcuri","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine at University of Miami, Miami, Florida, USA."},{"name":"Miami Integrative Metabolomics Research Center, Miami, Florida, USA."},{"name":"Molecular Cellular Pharmacology Graduate Program, University of Miami, Miami, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelrahman","family":"Elbaz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine at University of Miami, Miami, Florida, USA."},{"name":"Miami Integrative Metabolomics Research Center, Miami, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najam A.","family":"Sharif","sequence":"additional","affiliation":[{"name":"Eye-APC Duke-National University of Singapore Medical School, Singapore."},{"name":"Singapore Eye Research Institute, Singapore."},{"name":"Department of Pharmacology and Neuroscience, University of North Texas Health Sciences Center, Fort Worth, Texas, USA."},{"name":"Department of Pharmacy Sciences, Creighton University, Omaha, Nebraska, USA."},{"name":"Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA."},{"name":"Imperial College of Science and Technology, St. Mary's Campus, London, United Kingdom."},{"name":"Institute of Ophthalmology, University College London, London, United Kingdom."},{"name":"Ophthalmology Innovation Center and Product Development Division, Santen Inc., Emeryville, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjoy K.","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine at University of Miami, Miami, Florida, USA."},{"name":"Miami Integrative Metabolomics Research Center, Miami, Florida, 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