{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:53:27Z","timestamp":1777910007923,"version":"3.51.4"},"reference-count":64,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Ozurdex had shown promising anatomical and functional outcomes in managing refractory Irvine\u2013Gass syndrome over the years. Burgeoning usage of Ozurdex has prompted the study of its related complications, particularly the anterior chamber migration of the implant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Literature reviews on the anterior chamber migration of the Ozurdex via PubMed, EBSCO, and TRIP databases were searched from 2012 to 2020. The predisposing factors, outcomes, and management of such cases were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 54 articles consisting of 105 cases of anterior migration of Ozurdex were included in this analysis. The vitrectomized eye and compromised posterior capsule were highly associated with this complication. About 81.9% of the cases had cornea edema upon presentation, with 31.4% of them ending up with cornea decompensation despite intervention. Although there was high intraocular pressure reported initially in 22 cases, only 2 cases required glaucoma filtration surgeries in which they had preexisting glaucoma. Numerous techniques of repositioning or surgical removal of the implant were described but they were challenging and the outcomes varied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A noninvasive method of manipulating the Ozurdex into the vitreous cavity via the \u201cTrendelenburg position, external pressure with head positioning\u201d maneuvers is safe yet achieves a favorable outcome. Precaution must be taken whenever offering Ozurdex to the high-risk eyes. Prompt repositioning or removal of the implant is crucial to deter cornea decompensation. Clinical Trial Registration number: NMRR-22-02092-S9X (from the Medical Research and Ethics Committee (MREC), Ministry of Health, Malaysia).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2023.0012","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T14:20:51Z","timestamp":1694096451000},"page":"342-360","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Review of Risk Factors and Complications of Anterior Migration of Ozurdex Implant: Lessons Learnt from the Previous Reports"],"prefix":"10.1177","volume":"40","author":[{"given":"Hui Gim","family":"Khor","sequence":"first","affiliation":[{"name":"University of Malaya Eye Research Centre (UMERC), Department of Ophthalmology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia."},{"name":"University of Malaya Medical Centre, Kuala Lumpur, Malaysia."},{"name":"Department of Ophthalmology, Miri Hospital, Ministry of Health Malaysia, Sarawak, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pooi Wah","family":"Lott","sequence":"additional","affiliation":[{"name":"University of Malaya Eye Research Centre (UMERC), Department of Ophthalmology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia."},{"name":"University of Malaya Medical Centre, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azida Juana","family":"Wan Ab Kadir","sequence":"additional","affiliation":[{"name":"University of Malaya Eye Research Centre (UMERC), Department of Ophthalmology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia."},{"name":"University of Malaya Medical Centre, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujaya","family":"Singh","sequence":"additional","affiliation":[{"name":"University of Malaya Eye Research Centre (UMERC), Department of Ophthalmology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia."},{"name":"University of Malaya Medical Centre, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tajunisah","family":"Iqbal","sequence":"additional","affiliation":[{"name":"University of Malaya Eye Research Centre (UMERC), Department of Ophthalmology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia."},{"name":"University of Malaya Medical Centre, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"issue":"3","key":"e_1_3_6_2_2","first-page":"333","article-title":"Effectiveness and safety of dexamethasone implants for postsurgical macular oedema including Irvine-Gass syndrome: the EPISODIC-2 study","volume":"101","author":"Bellocq D","year":"2017","unstructured":"Bellocq D, , Pierre-Kahn V, , Matonti F, et al. Effectiveness and safety of dexamethasone implants for postsurgical macular oedema including Irvine-Gass syndrome: the EPISODIC-2 study. Br J Ophthalmol, 2017; 101(3):333\u2013341; doi: 10.1136\/bjophthalmol-2016-308544","journal-title":"Br J Ophthalmol"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002475"},{"key":"e_1_3_6_4_2","unstructured":"Allergan. OZURDEX\u00ae Full Prescribing Information. Irvine CA; Allergan (2020). 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