{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:17:25Z","timestamp":1790738245280,"version":"4.1.0"},"reference-count":73,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>\n                      Topical antihistamines, such as olopatadine hydrochloride, an H1 receptor antagonist, are commonly prescribed for treating allergic conjunctivitis. Drug delivery via eye drops has many deficiencies including a short residence time due to tear drainage via the nasolacrimal duct, which results in a low bioavailability and potential for side effects. These deficiencies could be mitigated by a drug-eluting contact lens such as the recently approved ACUVUE\n                      <jats:sup>\u00ae<\/jats:sup>\n                      THERAVISION\u2122 WITH KETOTIFEN which is a daily disposable etafilcon, a drug-eluting contact lens with ketotifen (19\u2009\u03bcg per lens). Here, we investigate the feasibility of designing a drug-eluting lens with sustained release of olopatadine for treating allergies using an extended wear lens.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Nanobarrier depots composed of vitamin-E (VE) are formed through direct entrapment by ethanol-driven swelling. The drug-loaded lenses are characterized for transparency and water content.\n                      <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                      release is measured under sink conditions and fitted to a diffusion control release model to determine diffusivity and partition coefficient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                      studies indicate that ACUVUE OASYS\n                      <jats:sup>\u00ae<\/jats:sup>\n                      and ACUVUE TruEye\u2122 lenses loaded with \u223c0.3\u2009g of VE\/g of hydrogel effectively prolong olopatadine dynamics by 7-fold and 375-fold, respectively. Incorporation of VE into the lenses retains visible light transmission and other properties.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The VE incorporation in commercial lenses significantly increases the release duration offering the possibility of antiallergy extended wear lenses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2023.0111","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T12:08:02Z","timestamp":1710504482000},"page":"126-135","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Sustained Delivery of Olopatadine from Vitamin-E Loaded Contact Lenses"],"prefix":"10.1177","volume":"40","author":[{"given":"In\u00eas M.","family":"Reis","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, University of Florida, Gainesville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Dixon","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, University of Florida, Gainesville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poorvajan","family":"Sekar","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, University of Florida, Gainesville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1920-2900","authenticated-orcid":false,"given":"Anuj","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, University of Florida, Gainesville, Florida, USA."},{"name":"Department of Chemical Engineering, Colorado School of Mines, Golden, Colorado, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1990.01070030090035"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(93)90036-7"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(86)90119-0"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.280318"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-010-0087-1"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.005"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(93)90035-6"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0149-2918(95)80058-1"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1984.01040030976029"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-39-18"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1998.0280s6039.x"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199243020-00003"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32834a9676"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2000.078s230038.x"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60130-X"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02877768"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200565020-00004"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.03.017"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1985.tb00255.x"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.09.005"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713689409167294"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2005.04.011"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.117591"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(86)33789-8"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)75754-X"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30223-1"},{"key":"e_1_3_4_28_2","first-page":"112","article-title":"The pharmacology of nedocromil sodium","volume":"147","author":"Eady R.","year":"1986","unstructured":"Eady R. 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