{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:03:09Z","timestamp":1778601789328,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To compare the efficacy of Brinzolamide-Brimonidine (BB) (1%+0.2%) with the gold standard Latanoprost-Timolol (LT) (0.005%+0.5%) in treating primary open-angle glaucoma (POAG) and ocular hypertension (OHT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A 1-year prospective study, spanning from May 2022 to May 2023, conducted at a tertiary eye-care hospital. Participants, aged 40\u201360, with a baseline intraocular pressure (IOP) &gt;21\u2009mm Hg, requiring a &gt;30% reduction, were enrolled. Group A (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009100) received BB, and Group B (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009100) received LT. Outcomes were assessed at 1 month (IOP difference from baseline), 3 and 6 months (mean diurnal variations).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean age at presentation was 55.5\u2009\u00b1\u20094.5 years in Group A and 54.7\u2009\u00b1\u20094.2 years in Group B. At 1 month, Group A exhibited a mean IOP of 18.7\u2009mm Hg, while Group B had 17.6\u2009mm Hg, with no statistically significant difference (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.53). No significant diurnal variation was observed in either group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.07). Target pressure was achieved in 88% of patients in Group A and slightly higher at 92% in Group B. Moreover, no serious side effects were reported, and compliance was higher in Group B (98%) compared to Group A (96%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although LT showed slightly better and sustained IOP reduction, the difference was not statistically significant. Both BB and LT demonstrated comparable outcomes for managing POAG and OHT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2023.0186","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T11:47:15Z","timestamp":1712749635000},"page":"240-245","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["A Comparative Study on Efficacy of Intraocular Pressure Lowering of Two Fixed-Dose Antiglaucoma Drug Combination Brinzolamide-Brimonidine Versus Latanoprost-Timolol in Primary Open-Angle Glaucoma and Ocular Hypertension"],"prefix":"10.1177","volume":"40","author":[{"given":"Avinash","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Military Hospital, Jalandhar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4510-0668","authenticated-orcid":false,"given":"Mohini","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Military Hospital, Jalandhar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anchal","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Military Hospital, Jammu, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul","family":"Bhirud","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Military Hospital, Jalandhar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lt Col Rajnish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Military Hospital, Danapur, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brig Baranwal","family":"Vinod K","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Sitapur Eye Hospital, Sitapur, India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/62.7.691"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2012.02773.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.081224"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.optom.2016.02.003"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/09286580701501931"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.081224"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12203"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/112067210801800517"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.05.019"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e3182058ead"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200825090-00002"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2008.08.010"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000548"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S63760"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S23780"},{"key":"e_1_3_3_17_2","first-page":"261","article-title":"Patient persistence with first-line antiglaucomatous monotherapy","author":"Arias A","year":"2010","unstructured":"Arias A, , Schargel K, , Ussa F, et al. 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