{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:36:39Z","timestamp":1790087799843,"version":"4.0.1"},"reference-count":17,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the efficacy of subconjunctival tranexamic acid (TXA) in reducing intraoperative bleeding, shortening surgery duration, and improving postoperative outcomes in pterygium surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In this double-blind, randomized controlled trial, 50 eyes of 50 patients undergoing pterygium surgery were randomly assigned to receive either subconjunctival injection of 0.25 mL of 5% TXA (TXA group,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 25) or an equivalent volume of saline (control group,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 25). Baseline characteristics, including age, gender, working environment, allergies, preoperative logMAR best-corrected visual acuity, and systemic anticoagulant or antiplatelet therapy, were similar between the groups. The primary outcome measures were intraoperative bleeding, surgery duration, and the number of eye spears used. Secondary outcome measures included postoperative visual acuity and pterygium recurrence rates at 3 years post-surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      No significant differences were observed between the TXA group and the control group in terms of surgery duration (445.3 \u00b1 94.8 s vs. 423.5 \u00b1 80.6 s,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.40), the number of eye spears used (3.5 \u00b1 2.4 vs. 3.5 \u00b1 2.6,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.97), or the weight of absorbed blood (1.94 \u00b1 1.40 grams vs. 1.90 \u00b1 1.25 grams,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.91). Additionally, there were no significant differences in postoperative visual acuity (0.14 \u00b1 0.13 logMAR vs. 0.20 \u00b1 0.19 logMAR, P = 0.39) or pterygium recurrence rates at 3 years post-surgery (8.0% vs. 4.4%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.60). Subconjunctival TXA injection was safe, with no reported adverse events or complications associated with its use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Subconjunctival injection of TXA did not significantly reduce intraoperative bleeding, shorten surgery duration, or improve postoperative outcomes in pterygium surgery. The intervention was safe and well-tolerated, but further research is warranted to explore alternative interventions or modifications to the surgical technique that may improve outcomes in pterygium surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2024.0068","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:05:31Z","timestamp":1732061131000},"page":"675-679","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Duration of Bare Sclera Pterygium Surgery Combined with Mitomycin C with and Without Tranexamic Acid: A Randomized Double-Blind Controlled Trial"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8092-0750","authenticated-orcid":false,"given":"Nevo","family":"Kovalis","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel."},{"name":"Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shmuel","family":"Graffi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel."},{"name":"Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadi","family":"Safuri","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel."},{"name":"Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinon","family":"Shapira","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel."},{"name":"Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel."},{"name":"Department of Ophthalmology, Carmel Medical Center, Haifa, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geulah","family":"Ben-David","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel."},{"name":"Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mimouni","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel."},{"name":"Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,2]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/S10792-016-0358-5"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.171508"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.18240\/IJO.2016.03.25"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011308.PUB2"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/APT.15761"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/112067210901900422"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005431.PUB3"},{"issue":"2","key":"e_1_3_5_9_2","first-page":"178","article-title":"Comparison between topical and oral tranexamic acid in management of traumatic hyphema","volume":"39","author":"Jahadi Hosseini SHR","year":"2014","unstructured":"Jahadi Hosseini SHR, , Khalili MR, , Motallebi M. 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