{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:02:11Z","timestamp":1789556531214,"version":"build-2803163510"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/Aims:<\/jats:title>\n                    <jats:p>To investigate the effectiveness of re-esterified triglyceride form of omega 3 (rTG-omega 3) on patients with meibomian gland dysfunction (MGD) after cataract surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This multicenter, randomized, investigator-blinded, clinical study was conducted between June 2021 and March 2023 and enrolled 107 patients with MGD who had undergone cataract surgery within 3 months at seven sites across South Korea. Patients were randomly assigned to rTG-omega 3 group or a control group. We compared (1) tear film break-up time (TBUT) (s), (2) corneal fluorescein staining score [National Eye Institute\/Industry (NEI) scale], (3) conjunctival fluorescein staining score (NEI scale), (4) strip meniscometry (SM) tube score (mm), (5) MGD stage, (6) MG quality, (7) MG expressibility, (8) Standard Patient Evaluation of Eye Dryness (SPEED) score, and (9) Ocular Surface Disease Index (OSDI) scores at baseline and 6 and 12 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      TBUT, corneal fluorescein staining score, and SM tube score were significantly improved in the rTG-omega 3 group compared with control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.005,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003, and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0049, respectively). Subjective questionnaire responses were also improved significantly (SPEED score,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.022; OSDI score,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0011). MGD parameters were not significantly different. However, during subanalysis, significant improvements in MG quality and expressibility were observed in the MGD stage 4 group with rTG-omega 3 supplementation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0177 and\n                      <jats:italic toggle=\"yes\">P =<\/jats:italic>\n                      0.0205, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>rTG-omega 3 supplementation facilitated improvements in both objective and subjective parameters. In particular, MG quality and expressibility were significantly improved in the severe MGD group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2024.0160","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T07:38:03Z","timestamp":1738741083000},"page":"65-74","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["A Multicenter, Randomized, Clinical Trial Assessing the Effect of rTG-Omega 3 Supplementation on Meibomian Gland Dysfunction Patients after Cataract Surgery rTG-Omega 3 for Meibomian Gland Dysfunction"],"prefix":"10.1177","volume":"41","author":[{"given":"Suji","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Korea University Guro Hospital, Seoul, Republic of Korea."},{"name":"Department of Ophthalmology, Seoul Shinsegae Eye Center, Eui Jung Bu, Gyeonggi-do, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minji","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Korea University Ansan Hospital, Gyeonggi-do, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngsub","family":"Eom","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Korea University Ansan Hospital, Gyeonggi-do, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Kyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kyungpook National University School of Medicine, Daegu, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Chul","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chonnam National University Medical School, Gwangju, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Sun","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yeouido St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Jin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dankook University College of Medicine, Cheonan, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Keun","family":"Lee","sequence":"additional","affiliation":[{"name":"The Institute of Vision Research, Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Suk","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Korea University Guro Hospital, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.003"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.03.006"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6997a"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-020-01294-8"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31812f67ca"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-012-0117-8"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2019.08.007"},{"key":"e_1_3_4_9_2","first-page":"1797","article-title":"Emerging treatment options for meibomian gland dysfunction","volume":"7","author":"Qiao J","year":"2013","unstructured":"Qiao J, , Yan X. 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