{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:54:22Z","timestamp":1777910062051,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the durability of thermomechanical device treatment effect in patients with meibomian gland dysfunction (MGD) at 6 months post-treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was an extension of an initial 3-month, prospective, controlled, randomized, masked, multicenter pivotal study, in which subjects with MGD were randomized to thermomechanical device treatment (3 sessions, 2 weeks apart) or a single control treatment. The extension study was a single-arm, observational study in the same 5 sites of the pivotal study. A subset of subjects from the thermomechanical device group with an increase in tear break-up time (TBUT) of 2.5 s or greater in at least 1 eye at 1- or 3-month follow-up and able to attend the 6-month follow-up were included. Effectiveness endpoints included changes in TBUT, Meibomian gland score (MGS), and Ocular Surface Disease Index (OSDI) from baseline to 6 months. Device-related adverse events (AEs) were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At 6 months post-treatment, 21 subjects (42 eyes) demonstrated significant improvements from baseline in mean TBUT (5.2 \u00b1 3.8 s;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), mean MGS (18.2 \u00b1 10.9;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001), and mean OSDI (\u221224.3 \u00b1 26.5;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0004). Improvements in corneal staining scores were also observed. No ocular AEs were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The findings of the extension study demonstrate that the clinical benefit of the thermomechanical device, evaluated by TBUT, MGS, and OSDI, can be maintained out to 6 months and that the device is safe and effective in improving the signs and symptoms of evaporative dry eye disease in MGD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jop.2025.0033","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T13:10:21Z","timestamp":1744809021000},"page":"237-243","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Durability of Treatment with a Thermomechanical Device in Meibomian Gland Dysfunction: An Observational Extension Study"],"prefix":"10.1177","volume":"41","author":[{"given":"Ehsan","family":"Sadri","sequence":"first","affiliation":[{"name":"Visionary Eye Institute, Newport Beach, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Verachtert","sequence":"additional","affiliation":[{"name":"Moyes Eye Center, PC, Kansas City, Missouri, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory D.","family":"Parkhurst","sequence":"additional","affiliation":[{"name":"Parkhurst NuVision, San Antonio, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Echegoyen","sequence":"additional","affiliation":[{"name":"Anterior Segment and Refractive Surgery, Gordon Schanzlin New Vision Institute, La Jolla, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ifat","family":"Klein","sequence":"additional","affiliation":[{"name":"Novoxel Ltd, Netanya, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Agmon Gerstein","sequence":"additional","affiliation":[{"name":"Novoxel Ltd, Netanya, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1830-8935","authenticated-orcid":false,"given":"Gregg J.","family":"Berdy","sequence":"additional","affiliation":[{"name":"Ophthalmology Associates, St. Louis, Missouri, USA."},{"name":"Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.008"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6997e"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.003"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6997c"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6997b"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2013.10.008"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.05.031"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-307415"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6997g"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.006"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P051185"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e318181adef"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000258"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318239aaea"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2011.631721"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S234008"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002837"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23494"},{"issue":"1","key":"e_1_3_6_20_2","first-page":"31","article-title":"Fractional treatment of aging skin with Tixel, a clinical and histological evaluation","volume":"18","author":"Elman M","year":"2016","unstructured":"Elman M, , Fournier N, , Barn\u00e9on G, et al. 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