{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:09:03Z","timestamp":1777914543284,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Palliative Medicine"],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Neurolytic celiac plexus block is increasingly used to treat refractory pain associated with abdominal malignancies, especially pancreatic cancer. While self-limiting diarrhea can occur commonly in patients post procedure, a very rare risk of persistent diarrhea exists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We present a case of a 70 year old female with locally advanced pancreatic adenocarcinoma who was hospitalized for persistent severe diarrhea post celiac plexus block and discuss management options for this adverse effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A review of the current literature within the past 20 years (PubMed and Ovid databases) was conducted to discuss alternatives of management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements\/Results:<\/jats:title>\n                    <jats:p>Ninety-three entries were found in total including duplicates and only two were included for relevance. Management options that were discussed included anti-motility agents, alpha-adrenergic agonists, and somastatin analog (octreotide). Our patient was initially treated with loperamide, hyoscine, psyllium, and cholestyramine before responding to octreotide. The patient was discharged on long-acting octreotide after her bowel routine stabilized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Persistent diarrhea is a very rare complication of celiac plexus block and current literature regarding proper management is based largely on anecdotal evidence. For this patient octreotide was an effective agent for the management of this complication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jpm.2015.0117","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T12:57:03Z","timestamp":1442581023000},"page":"83-86","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Persistent Diarrhea after Celiac Plexus Block in a Pancreatic Cancer Patient: Case Report and Literature Review"],"prefix":"10.1177","volume":"19","author":[{"given":"Anjie","family":"Yang","sequence":"first","affiliation":[{"name":"University Health Network","place":["Canada"]},{"name":"University of Toronto","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyn","family":"Brown","sequence":"additional","affiliation":[{"name":"University Health Network","place":["Canada"]},{"name":"University of Toronto","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernie","family":"Mak","sequence":"additional","affiliation":[{"name":"University Health Network","place":["Canada"]},{"name":"University of Toronto","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,1,1]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"CD007519","article-title":"Celiac plexus block for pancreatic cancer pain in adults","volume":"16","author":"Arcidiacono PG","year":"2011","unstructured":"Arcidiacono PG, , Calori G: Celiac plexus block for pancreatic cancer pain in adults. Cochrane Database Syst Rev, 2011; 16:CD007519.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12083"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2003.12.14.11414"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1049909111402185"},{"key":"e_1_3_2_6_2","first-page":"205","article-title":"Chronic diarrhea: An uncommon side effect of celiac plexus block","volume":"82","author":"Chan VW","year":"1996","unstructured":"Chan VW: Chronic diarrhea: An uncommon side effect of celiac plexus block. Anesth Analg, 1996; 82:205\u2013207.","journal-title":"Anesth Analg"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)00267-I"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-007-0399-4"},{"key":"e_1_3_2_9_2","unstructured":"Novartis Product Monograph. Sandostatin\u00ae and Sandostatin\u00ae LAR\u00ae. Health Canada Drug Product Database. webprod5.hc-sc.gc.ca\/dpd-bdpp\/info.do?code=9917&lang=eng>. [Last accessed June 22 2015.]"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1185\/03007990903328959"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e31821f66b4"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i6.1945"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2005.05.018"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1191\/0269216306070751"},{"key":"e_1_3_2_15_2","first-page":"380","article-title":"Octreotide LAR resolves severe chemotherapy induced diarrhoea (CID) and allows continuation of full dose therapy","volume":"13","author":"Rosenoff SH","year":"2004","unstructured":"Rosenoff SH: Octreotide LAR resolves severe chemotherapy induced diarrhoea (CID) and allows continuation of full dose therapy. Eur J Cancer Care, 2004; 13:380\u2013383.","journal-title":"Eur J Cancer Care"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.50.8077"},{"key":"e_1_3_2_17_2","first-page":"2325","article-title":"Octreotide long-acting formulation (LAR) in chronic loperamide-refractory diarrhea not related to cancer treatment","volume":"26","author":"Mystakidou K","year":"2006","unstructured":"Mystakidou K, , Katsouda E, , Tsilika E, et al.: Octreotide long-acting formulation (LAR) in chronic loperamide-refractory diarrhea not related to cancer treatment. Anticancer Res, 2006; 26:2325\u20132328.","journal-title":"Anticancer Res"},{"key":"e_1_3_2_18_2","first-page":"561","article-title":"Resolution of refractory chemotherapy-induced diarrhea (CID) with octreotide long-acting formulation in cancer patients: 11 case studies","volume":"12","author":"Rosenhoff SH","year":"2004","unstructured":"Rosenhoff SH: Resolution of refractory chemotherapy-induced diarrhea (CID) with octreotide long-acting formulation in cancer patients: 11 case studies. Support Care Cancer, 2004; 12:561\u2013570.","journal-title":"Support Care Cancer"},{"key":"e_1_3_2_19_2","first-page":"289","article-title":"A multi-center, randomized trial of long acting octreotide for the optimum prevention of chemotherapy-induced diarrhea: Results of the STOP trial","volume":"4","author":"Rosenhoff SH","year":"2006","unstructured":"Rosenhoff SH, , Gabrail NY, , Conklin R, et al.: A multi-center, randomized trial of long acting octreotide for the optimum prevention of chemotherapy-induced diarrhea: Results of the STOP trial. J Support Oncol, 2006; 4:289\u2013294.","journal-title":"J Support Oncol"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6478.1315"}],"container-title":["Journal of Palliative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jpm.2015.0117","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jpm.2015.0117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jpm.2015.0117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:55:01Z","timestamp":1777654501000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jpm.2015.0117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1,1]]}},"alternative-id":["10.1089\/jpm.2015.0117"],"URL":"https:\/\/doi.org\/10.1089\/jpm.2015.0117","relation":{},"ISSN":["1096-6218","1557-7740"],"issn-type":[{"value":"1096-6218","type":"print"},{"value":"1557-7740","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,1]]}}}