{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:14:55Z","timestamp":1777914895071,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:00:00Z","timestamp":1558396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Palliative Medicine"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Neoplastic pericardial effusion (NPE) is a life-threatening condition that can worsen clinical outcome in cancer patients. The optimal management of NPE has yet to be defined because randomized studies are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We report a retrospective monoinstitutional experience describing characteristics, management and prognostic factors in NPE patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>We reviewed clinical, pathological, and echocardiographic features, therapeutic strategies, and outcome in NPE patients referred to our institute from August 2011 to December 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements:<\/jats:title>\n                    <jats:p>Twenty-nine patients with NPE from solid tumors have been identified: 21 lung, 5 breast, and 3 other cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Median age was 62 years. Most of the patients had Eastern Cooperative Oncology Group (ECOG) performance status (PS) \u22652 (69%) and a symptomatic NPE (69%). In 52% of patients NPE was detected at first diagnosis of metastatic disease, and in 20% of patients pericardium was the only site of metastases. Most of the patients (62%) received systemic therapy, 28% received combined locoregional and systemic therapy, and 10% received locoregional therapy alone. Median overall survival (OS) from NPE diagnosis was 3.9 months. Patients with PS \u22652 had worse OS than patients with better PS &lt;2 (hazard ratio [HR] 3.56, IC 95% 1.19\u201310.65,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      0.02). Older age, extrapericardial disease, and NPE at progression showed a trend of association with worse OS. Patients treated with locoregional therapy alone showed the shortest median OS (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>NPE is related to dismal prognosis. Poor PS significantly worsens survival and influences therapeutic approaches. Randomized studies are required to investigate prognostic factors and appropriate clinical management for patients with NPE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jpm.2018.0491","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T15:57:31Z","timestamp":1553011051000},"page":"691-695","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Neoplastic Pericardial Effusion: A Monocentric Retrospective Study"],"prefix":"10.1177","volume":"22","author":[{"given":"Elisabetta","family":"Di Liso","sequence":"first","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, Universit\u00e0 degli Studi di Padova, Padova, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Menichetti","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, Universit\u00e0 degli Studi di Padova, Padova, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Vittoria","family":"Dieci","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, Universit\u00e0 degli Studi di Padova, Padova, Italy."},{"name":"Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Ghiotto","sequence":"additional","affiliation":[{"name":"Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Banzato","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Istituto Oncologico Veneto IRCCS, Padova, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Istituto Oncologico Veneto IRCCS, Padova, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Pintacuda","sequence":"additional","affiliation":[{"name":"Radiology Unit, Istituto Oncologico Veneto IRCCS, Padova, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Padovan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, Universit\u00e0 degli Studi di Padova, Padova, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floriana","family":"Nappo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, Universit\u00e0 degli Studi di Padova, Padova, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Cumerlato","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, Universit\u00e0 degli Studi di Padova, Padova, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Miglietta","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, Universit\u00e0 degli Studi di Padova, Padova, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Mioranza","sequence":"additional","affiliation":[{"name":"Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Zago","sequence":"additional","affiliation":[{"name":"Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Corti","sequence":"additional","affiliation":[{"name":"Radiotherapy Unit, Istituto Oncologico Veneto IRCCS, Padova, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Guarneri","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, Universit\u00e0 degli Studi di Padova, Padova, Italy."},{"name":"Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierfranco","family":"Conte","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, Universit\u00e0 degli Studi di Padova, Padova, Italy."},{"name":"Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,5,21]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"675","article-title":"A 30-year analysis of cardiac neoplasms at autopsy","volume":"21","author":"Butany J","year":"2005","unstructured":"Butany J, , Leong SW, , Carmichael K, et al.: A 30-year analysis of cardiac neoplasms at autopsy. 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