{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:16:39Z","timestamp":1777914999841,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Palliative Medicine"],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:p>\n                    Dexmedetomidine, a selective alpha\n                    <jats:sub>2<\/jats:sub>\n                    agonist, is traditionally used briefly for perioperative anesthesia and sedation of mechanically ventilated patients. Reports of its use in patients with opioid-induced hyperalgesia\n                    <jats:sup>1<\/jats:sup>\n                    and intractable pain and delirium\n                    <jats:sup>2<\/jats:sup>\n                    suggested it for patients who otherwise may have required palliative sedation to relieve suffering. We present the protocol developed by the interdisciplinary team in our intensive palliative care unit that allows for safe titrated administration without required vital sign monitoring outside the intensive care unit (ICU) (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/journals.sagepub.com\/doi\/suppl\/10.1089\/jpm.2019.0427\">Supplementary Appendix SA1<\/jats:ext-link>\n                    ). We describe its efficacy in eight patients who were receiving comfort-focused care.\n                  <\/jats:p>","DOI":"10.1089\/jpm.2019.0427","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T16:42:41Z","timestamp":1579192961000},"page":"1515-1517","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Dexmedetomidine: A Novel Strategy for Patients with Intractable Pain, Opioid-Induced Hyperalgesia, or Delirium at the End of Life"],"prefix":"10.1177","volume":"23","author":[{"given":"Mara Lacy","family":"Hofherr","sequence":"first","affiliation":[{"name":"Psychosocial Oncology and Palliative Care, Dana Farber Cancer Institute, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet L.","family":"Abrahm","sequence":"additional","affiliation":[{"name":"Psychosocial Oncology and Palliative Care, Dana Farber Cancer Institute, Boston, Massachusetts, USA."},{"name":"Department of Palliative Care, Brigham and Women's Hospital, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Rickerson","sequence":"additional","affiliation":[{"name":"Psychosocial Oncology and Palliative Care, Dana Farber Cancer Institute, Boston, Massachusetts, USA."},{"name":"Department of Palliative Care, Brigham and Women's Hospital, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2010.00973.x"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269216314556923"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2011.04.016"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2678-9"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199104000-00018"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199309000-00016"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S139387"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/15360288.2010.518227"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2005.8.666"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31816b2f43"}],"container-title":["Journal of Palliative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jpm.2019.0427","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jpm.2019.0427","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jpm.2019.0427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:06:55Z","timestamp":1777655215000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jpm.2019.0427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,14]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11,1]]}},"alternative-id":["10.1089\/jpm.2019.0427"],"URL":"https:\/\/doi.org\/10.1089\/jpm.2019.0427","relation":{},"ISSN":["1096-6218","1557-7740"],"issn-type":[{"value":"1096-6218","type":"print"},{"value":"1557-7740","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,14]]}}}