{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:00:23Z","timestamp":1790074823435,"version":"4.0.1"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Palliative Medicine"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Clinical usefulness of trazodone for delirium in patients receiving palliative care is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To examine the safety and effectiveness of trazodone for delirium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A secondary analysis of a multicenter prospective observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting\/Subjects:<\/jats:title>\n                    <jats:p>The setting involves nine psycho-oncology consultation services and 14 inpatient palliative care units in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements:<\/jats:title>\n                    <jats:p>The measurement involves the Delirium Rating Scale (DRS) Revised-98 for effectiveness and the CTCAE (Common Terminology Criteria for Adverse Events) version 4 for safety assessments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Thirty-eight patients enrolled the study. Mean age was 75 years. After three-day observation, the DRS total score (11.6\u2009\u00b1\u20095.3 to 8.7\u2009\u00b1\u20096.5 [difference \u22122.9, 95% confidence interval \u22125.3 to \u22120.5,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.02]); sleep\u2013wake cycle disturbance (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.047), lability of affect (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and motor agitation subscales (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were significantly decreased. The most frequent adverse event was somnolence (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20099).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Low-dose trazodone treatment was generally safe and may be effective in reducing delirium severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jpm.2020.0610","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T13:34:09Z","timestamp":1613223249000},"page":"914-918","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Low-Dose Trazodone for Delirium in Patients with Cancer Who Received Specialist Palliative Care: A Multicenter Prospective Study"],"prefix":"10.1177","volume":"24","author":[{"given":"Isseki","family":"Maeda","sequence":"first","affiliation":[{"name":"Department of Palliative Care, Senri-Chuo Hospital, Toyonaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Okayama University Hospital, Okayama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tonan Hospital, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Tanimukai","sequence":"additional","affiliation":[{"name":"Faculty of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, 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