{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:40:30Z","timestamp":1787683230358,"version":"build-2784847793"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Palliative Medicine"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Thrombotic disorders such as venous thromboembolism and disseminated intravascular coagulation (DIC) are known complications of solid tumors. To date, no reports have described the treatment of enhanced fibrinolytic-type DIC caused by end-of-life stage solid tumors. We encountered three cases of end-of-life stage solid tumors complicated by enhanced fibrinolytic-type DIC with severe bleeding symptoms. In all three cases, bleeding symptoms improved dramatically after intervention for enhanced fibrinolytic-type DIC with heparin(s) and tranexamic acid. Improvements in abnormal coagulation test results were also seen and the need for platelet concentrate transfusion and fresh frozen plasma infusion was able to be eliminated. However, one patient developed multiple cerebral infarctions. In the future, further studies to investigate the need for intervention in enhanced fibrinolytic-type DIC caused by end-of-life stage solid tumors and suitable treatment strategies are warranted.<\/jats:p>","DOI":"10.1089\/jpm.2022.0249","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T14:51:15Z","timestamp":1663253475000},"page":"307-311","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Anticoagulant\/Antifibrinolytic Combination Therapy on Enhanced Fibrinolytic-Type Disseminated Intravascular Coagulation in End-of-Life Stage Solid Tumor Patients"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7415-2918","authenticated-orcid":false,"given":"Shinya","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Hematology, Kanazawa University Hospital, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Suga","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Healthcare Science, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Science, Kanazawa University, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Morishita","sequence":"additional","affiliation":[{"name":"Department of Hematology, Kanazawa University Hospital, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidesaku","family":"Asakura","sequence":"additional","affiliation":[{"name":"Department of Hematology, Kanazawa University Hospital, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/2052-0492-2-20"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.08.102"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-6-378"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12342"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2021.2266"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.69.1150"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-020-03028-z"},{"key":"e_1_3_3_9_2","first-page":"ECR29","article-title":"Kasabach-Meritt syndrome associated with giant liver hemangioma: The effect of combined therapy with danaparoid sodium and tranexamic acid","volume":"90","author":"Ontachi Y","year":"2005","unstructured":"Ontachi Y, , Asakura H, , Omote M, et al. Kasabach-Meritt syndrome associated with giant liver hemangioma: The effect of combined therapy with danaparoid sodium and tranexamic acid. Haematologica, 2005; 90 Suppl:ECR29.","journal-title":"Haematologica"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02983996"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1616068"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.7326\/M14-1589"},{"issue":"3","key":"e_1_3_3_13_2","first-page":"828","article-title":"Disseminated intravascular coagulation in solid tumors: Clinical and pathologic study","volume":"86","author":"Sallah S","year":"2001","unstructured":"Sallah S, , Wan JY, , Nguen NP, et al. Disseminated intravascular coagulation in solid tumors: Clinical and pathologic study. Thromb Haemost, 2001; 86(3):828\u2013833.","journal-title":"Thromb Haemost"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14768"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031296"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12155"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-07375-2"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-014-0768-1"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1715840"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.04.027"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.6155"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.10.093"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3400\/avd.cr.20-00148"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V19.6.694.694"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196905152802006"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00023.2020"}],"container-title":["Journal of Palliative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jpm.2022.0249","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jpm.2022.0249","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jpm.2022.0249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:16:09Z","timestamp":1777655769000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jpm.2022.0249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,27]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1089\/jpm.2022.0249"],"URL":"https:\/\/doi.org\/10.1089\/jpm.2022.0249","relation":{},"ISSN":["1096-6218","1557-7740"],"issn-type":[{"value":"1096-6218","type":"print"},{"value":"1557-7740","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,27]]}}}