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A 39-year-old man with advanced pancreatic fibrosarcoma metastatic to the thoracic spine presented to the hospital with severe abdominal pain refractory to escalating doses of opioids. A celiac plexus block produced significant, yet inadequate, pain reduction. Satisfactory pain control and opioid de-escalation were ultimately achieved with the application of topical diclofenac gel to an area of bony metastasis. This case illustrates the potential for pain control using topical diclofenac in patients with pancreatic soft tissue tumors and vertebral metastases. Topical diclofenac may exert antitumoral effects and targeted application may improve absorption, leading to improved pain control. The use of topical diclofenac for pain management in metastatic pancreatic cancer presents an interesting tool that should be considered in similar cases.<\/jats:p>","DOI":"10.1089\/jpm.2023.0339","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T13:54:35Z","timestamp":1694440475000},"page":"576-578","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Topical Diclofenac to Manage Opioid-Refractory Pain in a Rare Pancreatic Fibrosarcoma"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0097-0958","authenticated-orcid":false,"given":"Syed H.","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Medicine and University of Texas at Austin Dell Medical School, Austin, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler","family":"Jorgensen","sequence":"additional","affiliation":[{"name":"Department of Medicine and University of Texas at Austin Dell Medical School, Austin, Texas, USA."},{"name":"Department of Hospice and Palliative Medicine, University of Texas at Austin Dell Medical School, Austin, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit K.","family":"Prasad","sequence":"additional","affiliation":[{"name":"University of Texas at Austin Dell Medical School, Austin, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Wallingford","sequence":"additional","affiliation":[{"name":"Department of Medicine and University of Texas at Austin Dell Medical School, Austin, Texas, USA."},{"name":"Department of Hospice and Palliative Medicine, University of Texas at Austin Dell Medical School, Austin, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13796"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4637.2001.002001028.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007400.pub3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-013-0394-z"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers3010043"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4488-z"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2011.06.006"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S186659"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007400.pub2"},{"key":"e_1_3_2_12_2","unstructured":"Chou R McDonagh MS Nakamoto E et al. 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