{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:24:11Z","timestamp":1777915451987,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Palliative Medicine"],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Naldemedine, a peripherally acting opioid \u03bc receptor antagonist, is effective for prevention of opioid-induced constipation (OIC); however, evidence on its use in children is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of naldemedine in pediatric patients with OIC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, Setting\/Subjects:<\/jats:title>\n                    <jats:p>Retrospective analysis of 32 pediatric patients with OIC treated with naldemedine in a single institution in Japan from June 2017 to March 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements:<\/jats:title>\n                    <jats:p>Efficacy was evaluated in 13 evaluable patients with bowel movement (BM) response, defined as those with at least three BMs in the first 7 days after naldemedine initiation and an increase of at least one BM from baseline. Safety was evaluated by examining adverse events (AEs) based on the Common Terminology Criteria for AEs (v5.0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      BM response was recorded in 11 of the 13 patients (85%), and the number BMs per day significantly increased from 0.43 before naldemedine to 1.00 after naldemedine (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.025). The most common AE was diarrhea, observed in 16 of the 32 patients (50%), and all instances were grade 1 or 2. In three of the 16 patients, naldemedine was discontinued owing to worsening diarrhea.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In pediatric patients, naldemedine resulted in a high rate of BM response and increased the BM frequency, indicating its efficacy. In some patients, grade 2 diarrhea required naldemedine discontinuation, suggesting that it should be used with caution in pediatric patients. Further studies are warranted to determine the optimal naldemedine dose in pediatric patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jpm.2024.0018","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T20:16:13Z","timestamp":1723234573000},"page":"1354-1358","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and Safety of Naldemedine for Opioid-Induced Constipation in Children"],"prefix":"10.1177","volume":"27","author":[{"given":"Rina","family":"Miura","sequence":"first","affiliation":[{"name":"Department of Pharmaceuticals, National Center for Child Health and Development, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Utano","sequence":"additional","affiliation":[{"name":"Department of Pharmaceuticals, National Center for Child Health and Development, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoriko","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Pharmaceuticals, National Center for Child Health and Development, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Pharmaceuticals, National Center for Child Health and Development, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayaka","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceuticals, National Center for Child Health and Development, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Takafuji","sequence":"additional","affiliation":[{"name":"Department of Pharmaceuticals, National Center for Child Health and Development, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayato","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceuticals, National Center for Child Health and Development, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayano","family":"Tanzawa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceuticals, National Center for Child Health and Development, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kana","family":"Iwahashi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceuticals, National Center for Child Health and Development, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akimasa","family":"Yamatani","sequence":"additional","affiliation":[{"name":"Department of Pharmaceuticals, National Center for Child Health and Development, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Yotani","sequence":"additional","affiliation":[{"name":"Division of Palliative Medicine, National Center of Child Health and Development, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2017.06.001"},{"key":"e_1_3_3_3_2","volume-title":"WHO Guidelines on the Pharmacological Treatment of Persisting Pain in children with Medical Illnesses","author":"World Health Organization","year":"2012","unstructured":"World Health Organization. WHO Guidelines on the Pharmacological Treatment of Persisting Pain in children with Medical Illnesses. World Health Organization: Geneva, 2012."},{"key":"e_1_3_3_4_2","volume-title":"WHO guidelines for the pharmacological and radiotherapeutic management of cancer pain in adults and adolescents","author":"World Health Organization","year":"2018","unstructured":"World Health Organization. WHO guidelines for the pharmacological and radiotherapeutic management of cancer pain in adults and adolescents. 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