{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:24:54Z","timestamp":1777915494145,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Palliative Medicine"],"published-print":{"date-parts":[[2025,6]]},"abstract":"\n Objective:<\/jats:title>\n Spiritual well-being (SWB) has been shown to delay the onset of cognitive decline among older adults predisposed to Alzheimer\u2019s disease and related neurodegenerative dementias. It was, however, unknown if SWB is also associated with delay in disease manifestation (\u201cphenoconversion\u201d) in rare, genetic neurodegenerative dementias, such as Huntington\u2019s disease (HD). Thus, we sought to evaluate the association between SWB and phenocovnersion in people at-risk for HD.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n The \u201cProspective Huntington At Risk Observation Study\u201d (PHAROS), a large-scale national prospective research study, recruited a substantial cohort of 1001 participants. These participants, who were first-degree relatives of individuals diagnosed with HD and had a 50% chance of carrying the HD genetic mutation, were blinded to their genetic status and underwent repeated clinical assessments every 12 months. The study used Cox proportional models to examine the relationship between SWB and time to phenoconversion while also considering subcomponents of SWB and adjusting for age, sex, and CAG repeat length.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The study found no significant association between SWB and time to phenoconversion in individuals with the HD gene mutation.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n While existing data suggest that SWB may be an actionable target to improve health-related quality of life in HD and other serious illnesses, there is a lack of evidence supporting the role of SWB in attenuating phenoconversion in people with the HD genetic mutation. Unlike Alzheimer\u2019s, HD may be less responsive to analogous factors in delaying disease onset.<\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/jpm.2024.0227","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T03:19:51Z","timestamp":1741144791000},"page":"803-807","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Spiritual Well-Being and Phenoconversion in Huntington\u2019s Disease: Analysis from the Prospective Huntington at Risk Observational Study"],"prefix":"10.1177","volume":"28","author":[{"given":"Leonard L.","family":"Sokol","sequence":"first","affiliation":[{"name":"The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA."},{"name":"McGaw Bioethics Scholars Program, Center for Bioethics and Humanities, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA."},{"name":"Division of Palliative Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA."},{"name":"Division of Neurology, Department of Medicine, Scripps Clinic, La Jolla, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marissa C.","family":"Ashner","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danny","family":"Bega","sequence":"additional","affiliation":[{"name":"The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benzi M.","family":"Kluger","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Medicine, University of Rochester Medical Center, Rochester, New York, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander K.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Medicine, University of California, San Francisco, San Francisco, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen S.","family":"Marder","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University Medical Center, New York, New York, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya P.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the PHAROS Investigators of the Huntington Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13310-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2021.05.007"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.208"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51424"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.7.991"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/009164718301100406"},{"issue":"11","key":"e_1_3_3_8_2","first-page":"1382","article-title":"Relationship of mediterranean diet and caloric intake to phenoconversion in Huntington disease","volume":"70","author":"Marder K","year":"2013","unstructured":"Marder K, , Gu Y, , Eberly S, et al.; Huntington Study Group PHAROS Investigators. Relationship of mediterranean diet and caloric intake to phenoconversion in Huntington disease. JAMA Neurol, 2013; 70(11):1382\u20131388.","journal-title":"JAMA Neurol"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.116523"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.11.038"}],"container-title":["Journal of Palliative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jpm.2024.0227","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jpm.2024.0227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jpm.2024.0227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:21:53Z","timestamp":1777656113000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jpm.2024.0227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1089\/jpm.2024.0227"],"URL":"https:\/\/doi.org\/10.1089\/jpm.2024.0227","relation":{},"ISSN":["1096-6218","1557-7740"],"issn-type":[{"value":"1096-6218","type":"print"},{"value":"1557-7740","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]}}}