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Here, we present the case of a patient whose intractable pain was successfully palliated with a dexmedetomidine infusion but who then developed severe withdrawal when the infusion was stopped with a change in her plan of care. We present a review of the literature around transitioning patients off dexmedetomidine and highlight the need for more guidance on nonintensive care unit management of its side effects and alternatives.<\/jats:p>","DOI":"10.1089\/jpm.2025.0053","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T10:00:26Z","timestamp":1745229626000},"page":"1416-1420","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Utilizing Dexmedetomidine for Opioid-Resistant Pain and Anxiety in the Palliative Care Unit: A Case Report on Efficacy, Withdrawal Challenges, and Protocol Adaptations"],"prefix":"10.1177","volume":"28","author":[{"given":"Matthew","family":"Mason","sequence":"first","affiliation":[{"name":"UC San Diego &amp; Scripps Health Palliative Medicine Fellowship, San Diego, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Mesarwi","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Gerontology, &amp; 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