{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:11:24Z","timestamp":1788495084538,"version":"build-2803163510"},"reference-count":51,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Palliative Medicine"],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients with advanced nonsmall cell lung cancer (NSCLC) experience burdensome symptoms, psychological distress, and poor quality of life (QOL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We developed and pilot-tested a digital health application (\u201cTHRIVE\u201d), consisting of six modules designed to improve patients\u2019 symptom management and coping with NSCLC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Randomized pilot feasibility trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting\/Subjects:<\/jats:title>\n                    <jats:p>Eligible patients included adults within 12 weeks of an advanced NSCLC diagnosis receiving care at a participating institution in the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements:<\/jats:title>\n                    <jats:p>Participants completed baseline and 12-week assessments of QOL (Functional Assessment of Cancer Therapy-Lung), physical symptoms (MD Anderson Symptom Inventory; MDASI), psychological distress (Hospital Anxiety and Depression Scale), and coping (Brief COPE). The primary outcome was study feasibility, defined as \u226565% of approached patients consenting to participate; \u226570% of intervention participants completing \u22654 of 6 app modules; and \u226570% of the sample completing the 12-week assessments. We used the System Usability Scale (SUS) to assess intervention acceptability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 232 patients approached, 135 (58.2%) provided consent, and 120 (51.7%) were randomized (Age\n                      <jats:sub>mean<\/jats:sub>\n                      = 67.90 years, 61.7% female, 90.8% White). Among intervention participants, 70.5% (43\/61) completed \u22654 modules, with 77.3% reporting above-average SUS usability ratings for THRIVE. Ninety-four (78.3%) participants completed the 12-week assessments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although the enrollment rate was lower than anticipated, patients with advanced NSCLC who received THRIVE met the feasibility criterion for app completion and reported high acceptability. These results support conducting a follow-up efficacy trial of THRIVE for improving patients\u2019 QOL, physical symptoms, and other psychosocial outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jpm.2025.0066","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T03:24:58Z","timestamp":1749093898000},"page":"1210-1219","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Pilot Feasibility Trial of a Supportive Care Digital Application for Patients with Advanced Nonsmall Cell Lung Cancer"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1368-6350","authenticated-orcid":false,"given":"Mary C.","family":"Boulanger","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital, Boston, Massachusetts, USA."},{"name":"Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Lo","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, Massachusetts, USA."},{"name":"Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joely A.","family":"Centracchio","sequence":"additional","affiliation":[{"name":"University of Miami, Coral Gables, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna","family":"Jewett","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Freese","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Holtze","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie M.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, Massachusetts, USA."},{"name":"Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Petrillo","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, Massachusetts, USA."},{"name":"Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Bauman","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areej","family":"El-Jawahri","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, Massachusetts, USA."},{"name":"Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Temel","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, Massachusetts, USA."},{"name":"Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Greer","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, Massachusetts, USA."},{"name":"Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2017.02.008"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2019.11.015"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-1959-4"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.0033"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.70.1474"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000678"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.7996"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.4459"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.70.5046"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.21037\/apm-22-162"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2018.0092"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780197525173.001.0001"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/OP.21.00516"},{"issue":"3","key":"e_1_3_4_15_2","first-page":"122","article-title":"Early integration of palliative care into oncology: Evidence, challenges and barriers","volume":"4","author":"Zhi WI","year":"2015","unstructured":"Zhi WI, , Smith TJ. Early integration of palliative care into oncology: Evidence, challenges and barriers. Ann Palliat Med, 2015; 4(3):122\u2013131.","journal-title":"Ann Palliat Med"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2015.12.013"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2013.03.008"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.2581"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/16506070903318960"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/16506070802694776"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-019-00777-7"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-018-0730-8"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4867"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34645"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2009.11.001"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.0830"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1200\/CCI.22.00185"},{"key":"e_1_3_4_28_2","unstructured":"IQVIA Institute. Digital Health Trends: Innovation. Evidence Regulation and Adoption. 2021."},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/2055207620905413"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-019-0093-1"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.2196\/12645"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-025483"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2013.03.008"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1200\/OP.24.00299"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34369"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2627"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.1874"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.6676"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.73.7221"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2023.1184482"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1080\/10447310802205776"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-5002(95)00450-F"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(01)00477-2"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001001)89:7<1634::AID-CNCR29>3.0.CO;2-V"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(01)00358-X"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1207\/s15327558ijbm0401_6"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2016.06.005"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11135-006-9018-6"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1080\/10447318.2018.1455307"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.2196\/42092"}],"container-title":["Journal of Palliative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jpm.2025.0066","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jpm.2025.0066","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jpm.2025.0066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T04:37:54Z","timestamp":1784349474000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jpm.2025.0066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,5]]},"references-count":51,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,1]]}},"alternative-id":["10.1089\/jpm.2025.0066"],"URL":"https:\/\/doi.org\/10.1089\/jpm.2025.0066","relation":{},"ISSN":["1096-6218","1557-7740"],"issn-type":[{"value":"1096-6218","type":"print"},{"value":"1557-7740","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,5]]}}}