{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:33:28Z","timestamp":1777916008370,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Women's Health"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the underlying histology of HIV-infected women with minimally abnormal Pap tests compared to HIV-uninfected women by evaluating their colposcopic and histologic outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective analysis was performed to identify HIV-infected women who had at least one cervical Pap test from 2002 through 2008 at Boston Medical Center. We identified women who underwent colposcopy within 6 months of a minimally abnormal Pap test (atypical squamous cells of undetermined significance with positive high-risk human papillomavirus testing [ASCUS\/HPV+] or low-grade squamous intraepithelial lesion (LSIL)). Our outcome was the proportion of HIV-infected women with histologic cervical intraepithelial neoplasia 2 or worse (CIN2+). We then compared these outcomes to those of a cohort of HIV-uninfected women from the same institution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were 655 HIV-infected women who had Pap testing in the study time frame, and 146 (22%) had a minimally abnormal Pap test (ASCUS\/HPV+ or LSIL). Of the 90 HIV-infected women who had subsequent colposcopy within 6 months, colposcopy was negative for 20 (22%), CIN1 for 41 (46%), and CIN2+ for the remaining 29 (32%). During the same time period, there were 747 HIV-uninfected women who underwent colposcopy within 6 months of a minimally abnormal Pap test. Colposcopy was negative for 336 (45%), CIN1 for 254 (34%), and CIN2+ for 157 (21%). After adjusting for differences in age and race, the HIV-infected women were more likely to have CIN2+ after a minimally abnormal Pap test (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.002) (adjusted odds ratio [OR] 2.17, 95% confidence interval [CI] 1.33-3.62). There were no diagnosed cases of cervical cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>HIV-infected women have higher rates of underlying CIN2+ for minimally abnormal Pap tests compared with HIV-uninfected women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jwh.2010.2562","type":"journal-article","created":{"date-parts":[[2011,10,19]],"date-time":"2011-10-19T16:16:23Z","timestamp":1319040983000},"page":"87-91","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Minimally Abnormal Pap Testing and Cervical Histology in HIV-Infected Women"],"prefix":"10.1177","volume":"21","author":[{"given":"Christine L.","family":"Curry","sequence":"first","affiliation":[{"name":"Boston University Medical Campus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael Hoffman","family":"Sage","sequence":"additional","affiliation":[{"name":"Boston University Medical Campus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivera","family":"Vragovic","sequence":"additional","affiliation":[{"name":"Boston University Medical Campus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Stier","sequence":"additional","affiliation":[{"name":"Boston University Medical Campus"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,1,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp205"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm010"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-199905010-00005"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.5.397"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23760"},{"key":"e_1_3_2_7_2","article-title":"Trends in cervical cancer in the Netherlands until 2007: Has the bottom been reached?","author":"de Kok IM","year":"2010","unstructured":"de Kok IM, , van der Aa MA, , van Ballegooijen M et al. On behalf of the Working Group Output of the Netherlands Cancer Registry. Trends in cervical cancer in the Netherlands until 2007: Has the bottom been reached? Int J Cancer, 2010[Epub ahead of print, PMID: 20626043]","journal-title":"Int J Cancer"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/500404"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181bc6ce0"},{"key":"e_1_3_2_10_2","first-page":"1795","article-title":"High recurrence rate of cervical dysplasia and persistence of HPV infection in HIV-1-infected women","volume":"27","author":"Gingelmaier A","year":"2007","unstructured":"Gingelmaier A, , Grubert T, , Kaestner R et al. High recurrence rate of cervical dysplasia and persistence of HPV infection in HIV-1-infected women. Anticancer Res, 2007; 27:1795\u20131798.","journal-title":"Anticancer Res"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22015"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91889-7"},{"key":"e_1_3_2_13_2","first-page":"351","article-title":"Effect of patient age on outcomes and compliance in women with minimally abnormal Pap tests","volume":"55","author":"Carter J","year":"2010","unstructured":"Carter J, , Hoffman Sage Y, , Vragovic O, , Rosen L, , Stier E. Effect of patient age on outcomes and compliance in women with minimally abnormal Pap tests. J Reprod Med, 2010; 55:351\u2013356.","journal-title":"J Reprod Med"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00472-6"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000320309.34046.89"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/154099904322966128"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00128360-200410000-00007"},{"key":"e_1_3_2_18_2","article-title":"Human papillomavirus infection and cytologic abnormalities of the anus and cervix among HIV-infected women in the Study to Understand the Natural history of HIV\/AIDS in the era of effective therapy (The SUN Study)","author":"Kojic E","year":"2010","unstructured":"Kojic E, , Cu-Uvin S, , Conley L et al. Human papillomavirus infection and cytologic abnormalities of the anus and cervix among HIV-infected women in the Study to Understand the Natural history of HIV\/AIDS in the era of effective therapy (The SUN Study) Sex Transm Dis, 2010[Epub ahead of print, PMID 20966828]","journal-title":"Sex Transm Dis"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/505876"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1086\/500404"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181744619"},{"key":"e_1_3_2_22_2","first-page":"1","article-title":"Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: Recommendation from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. Centers for Disease Control and Prevention (CDC); National Institutes of Health; HIV Medicine Association of the Infectious Disease Society of America","volume":"58","author":"Kaplan JE","year":"2009","unstructured":"Kaplan JE, , Benson C, , Holmes KH, , Brooks JT, , Pau A, , Masur H. Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: Recommendation from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. Centers for Disease Control and Prevention (CDC); National Institutes of Health; HIV Medicine Association of the Infectious Disease Society of America. MMWR Recomm Rep, 2009; 58:1\u2013207.","journal-title":"MMWR Recomm Rep"},{"key":"e_1_3_2_23_2","unstructured":"American College of Obstetricians and Gynecologists. Practice bulletin number 117. 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