{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T04:29:47Z","timestamp":1783225787328,"version":"3.54.6"},"reference-count":13,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Women's Health"],"published-print":{"date-parts":[[2017,6]]},"abstract":"\n Background:<\/jats:title>\n \n BRCA1<\/jats:italic>\n and\n BRCA2<\/jats:italic>\n gene mutations carry with them a 50%\u201380% risk of developing breast cancer. The best choice for managing breast cancer risk in patients with a\n BRCA1\/2<\/jats:italic>\n mutation is a highly personal decision. Options for risk management include surveillance with multiple modalities or prophylactic surgical intervention. The goal of this study was to gain a better understanding of contributing factors affecting the decision for managing breast cancer risk made by patients who are\n BRCA<\/jats:italic>\n mutation positive and cancer free.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n A retrospective chart review of patients, who tested positive for\n BRCA1\/2<\/jats:italic>\n gene mutation between 2003 and 2013 without history of breast cancer, was performed. A logistic regression model was used to assess the association between preselected risk factors and the decision of the patient to undergo prophylactic mastectomy versus surveillance.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Of the 106 patients who were cancer free and\n BRCA<\/jats:italic>\n positive, seventy (66%) opted for surveillance, whereas 36 (34%) chose prophylactic mastectomy. Three preselected risk factors were found to significantly affect a patient's likelihood of choosing surgery: having a family member with breast cancer before the age of 50 (OR: 4.67 [95% CI: 1.86\u201311.68]),\n p<\/jats:italic>\n \u2009=\u20090.001), cancer-related death of a relative younger than 50 years old (OR: 2.26 [95% CI: 0.92\u20135.55],\n p<\/jats:italic>\n \u2009=\u20090.07), and prophylactic oophorectomy before planned mastectomy (OR: 3.72 [95% CI: 1.49\u20139.31],\n p<\/jats:italic>\n \u2009=\u20090.005). Patient age less than 30 was found to be significantly associated with the decision to proceed with surveillance (OR: 0.2 [95% CI: 0.05\u20130.75],\n p<\/jats:italic>\n \u2009=\u20090.02).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Risk-reducing strategy is a very personal decision for the patient with positive\n BRCA<\/jats:italic>\n mutation, and many factors go into choosing which options are best for each individual. We found that age of patient, relative with breast cancer or death of a relative before age 50, and prophylactic oophorectomy all play significant roles in which risk reduction strategy is chosen.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/jwh.2016.5931","type":"journal-article","created":{"date-parts":[[2016,12,6]],"date-time":"2016-12-06T16:46:40Z","timestamp":1481042800000},"page":"702-706","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Breast Cancer Risk Reduction Decisions of the\n BRCA<\/i>\n -Positive Patient: An Observational Study at a Single Institution"],"prefix":"10.1177","volume":"26","author":[{"given":"Dana","family":"Johns","sequence":"first","affiliation":[{"name":"University of Utah Health Sciences Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute\u2013University of Utah Health Care"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layla","family":"Anderson","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute\u2013University of Utah Health Care"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ying","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute\u2013University of Utah Health Care"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Kohlmann","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute\u2013University of Utah Health Care"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,6,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000153220.66955.39"},{"key":"e_1_3_2_3_2","unstructured":"Genetic\/Familial High-risk Assessment: Breast and ovarian NCCN practice guidelines 2016. Available at: www.nccn.org\/professionals\/physician_gls\/pdf\/genetics_screening.pdf Accessed September11 2016."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.21.1633"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107193450301"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1237"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.6875"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705153362022"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6970"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22352"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-5-200509060-00012"},{"key":"e_1_3_2_12_2","first-page":"260847","article-title":"Identification, evaluation, and treatment of patients with hereditary cancer risk within the United States","volume":"2013","author":"Cragun D","year":"2013","unstructured":"Cragun D, , Pal T. Identification, evaluation, and treatment of patients with hereditary cancer risk within the United States. ISRN Oncol, 2013; 2013:260847.","journal-title":"ISRN Oncol"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.05.028"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015269620265"}],"container-title":["Journal of Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jwh.2016.5931","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jwh.2016.5931","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jwh.2016.5931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:45:04Z","timestamp":1777657504000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jwh.2016.5931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1089\/jwh.2016.5931"],"URL":"https:\/\/doi.org\/10.1089\/jwh.2016.5931","relation":{},"ISSN":["1540-9996","1931-843X"],"issn-type":[{"value":"1540-9996","type":"print"},{"value":"1931-843X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}