{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:39:20Z","timestamp":1777916360987,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Women's Health"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To assess the emotional, reproductive, sexual health, and relationship concerns of women treated for gestational trophoblastic neoplasia (GTN) and examine associations with \u00df-hCG surveillance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This institutional review board approved study surveyed GTN survivors (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200951) who received treatment from 1996 to 2008. Fifty-one women, including those actively followed or formerly treated, were surveyed. The survey consisted of background\/medical information, the Reproductive Concerns Scale, the Female Sexual Function Index, an item from the Abbreviated Dyadic Adjustment Scale, the Center for Epidemiologic Studies\u2013Depression scale, the Menopausal Symptom Checklist, the Impact of Life Events Scale, and exploratory items.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean age at diagnosis was 37.1 years; 41.6 years at study enrollment. Twenty-seven patients (56%) expressed worry about treatment harm and 30 (60%) about recurrence. Twenty percent reported significant depressive symptomatology. Mild cancer-related distress, reproductive concerns, sexual dysfunction, and bothersome menopausal symptoms were noted. Nineteen patients (40%) rated their \u00df-hCG surveillance worry as \u201chigh.\u201d Among patients who attempted conception after treatment, 3 of 12 (25%) succeeded in the \u00df-hCG high-worry group versus 13 of 19 (68%) in the \u00df-hCG low-worry group. Survivors with high \u00df-hCG worry had greater reproductive concerns than those with low worry (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.002) and reported less sexual desire (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.025). There was no difference in the number of low-worry versus high-worry participants in active surveillance (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.09).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study suggests that cancer-specific distress, sexual health, and reproductive concerns continue to impact women years after treatment. High worry about \u00df-hCG surveillance is negatively associated with the emotional well-being of GTN survivors and possibly influences reproductive attempts and success.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jwh.2016.6208","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T16:14:41Z","timestamp":1513872881000},"page":"387-393","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of \u00df-hCG Surveillance with Emotional, Reproductive, and Sexual Health in Women Treated for Gestational Trophoblastic Neoplasia"],"prefix":"10.1177","volume":"27","author":[{"given":"Elizabeth L.","family":"Jewell","sequence":"first","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center"},{"name":"Weill Cornell Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Aghajanian","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center"},{"name":"Weill Cornell Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Montovano","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharyn N.","family":"Lewin","sequence":"additional","affiliation":[{"name":"Holy Name Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond E.","family":"Baser","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Carter","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center"},{"name":"Memorial Sloan Kettering Cancer Center"},{"name":"Weill Cornell Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,3,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/01674829309084447"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1188\/11.CJON.625-632"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3138"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.01.015"},{"key":"e_1_3_3_6_2","first-page":"595","article-title":"Sexual dysfunction as a complication of treatment of gestation trophoblastic neoplasia","volume":"53","author":"Cagayan MS","year":"2008","unstructured":"Cagayan MS. Sexual dysfunction as a complication of treatment of gestation trophoblastic neoplasia. J Reprod Med, 2008; 53:595\u2013599.","journal-title":"J Reprod Med"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e3182259c04"},{"key":"e_1_3_3_8_2","first-page":"239","article-title":"Assessment of quality of life and psychologic aspects in patients with gestational trophoblastic disease","volume":"54","author":"Ferreira EG","year":"2009","unstructured":"Ferreira EG, , Maest\u00e1 I, , Michelin OC, , de Paula RC, , Consonni M, , Rudge MV. Assessment of quality of life and psychologic aspects in patients with gestational trophoblastic disease. J Reprod Med, 2009; 54:239\u2013244.","journal-title":"J Reprod Med"},{"key":"e_1_3_3_9_2","first-page":"641","article-title":"[Gestational trophoblastic disease: Psychological impact and the role of defence mechanisms during illness and follow-up]","volume":"106","author":"Di Mattei VE","year":"2015","unstructured":"Di Mattei VE, , Mazzetti M, , Carnelli L, et al. [Gestational trophoblastic disease: Psychological impact and the role of defence mechanisms during illness and follow-up]. Recenti Prog Med, 2015; 106:641\u2013645.","journal-title":"Recenti Prog Med"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153869"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgi017"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/009262300278597"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26739"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2307\/350547"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0013164484444029"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/08870448808400349"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.9.2659"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-197905000-00004"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.07.016"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-010-0121-2"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128354"},{"key":"e_1_3_3_22_2","first-page":"387","article-title":"Quality of life after gestational trophoblastic disease","volume":"47","author":"Wenzel L","year":"2002","unstructured":"Wenzel L, , Berkowitz RS, , Newlands E, et al. Quality of life after gestational trophoblastic disease. J Reprod Med, 2002; 47:387\u2013394.","journal-title":"J Reprod Med"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds575"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1191\/0269216302pm507oa"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.06.078"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00493-8"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.03.046"}],"container-title":["Journal of Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/jwh.2016.6208","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jwh.2016.6208","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/jwh.2016.6208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:46:08Z","timestamp":1777657568000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/jwh.2016.6208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1089\/jwh.2016.6208"],"URL":"https:\/\/doi.org\/10.1089\/jwh.2016.6208","relation":{},"ISSN":["1540-9996","1931-843X"],"issn-type":[{"value":"1540-9996","type":"print"},{"value":"1931-843X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}