{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:42:45Z","timestamp":1792636965202,"version":"4.5.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Women's Health"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Despite high prevalence rates among women of mood disorders and of infertility, there is a paucity of systematic data to inform the treatment of women at risk for psychiatric morbidity in the context of assisted reproductive technologies (ART). The objective was to delineate predictors of depressive relapse in women with histories of mood disorders during ART, including the role of psychotropic medication continuation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a prospective observational study of women undergoing ART with past diagnoses of major depressive disorder (MDD) or bipolar depression. For 6-months, follow-up included assessments of mood, perceived stress, and partner support. A subsample participated in biomarker collection. Depressive relapse was confirmed using Mini-International Neuropsychiatric Interview.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      \u2009=\u200938 were evaluable. Participants with MDD (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      \u2009=\u200925) experienced a depressive relapse rate of 44.0%. Relapse rates among antidepressant maintainers (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      \u2009=\u200915; relapse rate\u2009=\u200940.0%) and antidepressant discontinuers (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      \u2009=\u200910; relapse rate\u2009=\u200950.0%) were not significantly different. Among participants with bipolar disorder (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      \u2009=\u200913), the overall relapse rate was 30.8%. Among psychotropic medication maintainers (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      \u2009=\u200910), 40.0% relapsed, and among discontinuers (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      \u2009=\u20093), none relapsed. Scores on the Perceived Stress Scale correlated with relapse risk (odds ratio [OR]\u2009=\u20091.17, 95% confidence interval [CI]: 1.08\u20131.26,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.0065). C-reactive protein was associated with relapse (OR\u2009=\u20091.92, 95% CI: 1.43\u20132.55,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.0001); blood cortisol and interleukin-6 were not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Risk of depressive relapse among women undergoing ART is considerable. Medication continuation does not adequately confer relapse prevention. Stress and inflammation appear to contribute to risk of relapse. Additional strategies to mitigate depressive relapse in at-risk women undergoing ART are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jwh.2017.6878","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T11:27:48Z","timestamp":1533122868000},"page":"1408-1414","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Predictors of Depressive Relapse in Women Undergoing Infertility Treatment"],"prefix":"10.1177","volume":"27","author":[{"given":"Marlene P.","family":"Freeman","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Lee","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina M.","family":"Savella","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra Z.","family":"Sosinsky","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha P.","family":"Marfurt","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon K.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee S.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,11,2]]},"reference":[{"issue":"7","key":"e_1_3_3_2_2","first-page":"9","article-title":"Epidemiology of depression throughout the female life cycle","volume":"63","author":"Burt VK","year":"2002","unstructured":"Burt VK, , Stein K. 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