{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:11:26Z","timestamp":1779106286920,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Women's Health"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Whether the sex factor influences the benefit of the implantable cardioverter-defibrillator (ICD) for the prevention of sudden death remains a subject of debate. Using a prospective registry, we sought to analyze the survival and time to first ICD therapy according to sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Retrospective analysis of a prospective cohort of patients undergoing an ICD implant from 2008 to 2019. Data about time to first appropriate therapy, type of therapy administered, and incidence and causes of mortality were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 756 ICD patients, 150 (19.8%) were women. Women were younger (51\u2009\u00b1\u200915 years vs. 61\u2009\u00b1\u200914 years;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and showed a lower rate of ischemic cardiomyopathy (23% vs. 54%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and atrial fibrillation (12% vs. 19%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.05). Women had higher left ventricular ejection fraction (39%\u2009\u00b1\u200917% vs. 35%\u2009\u00b1\u200913%) and showed more frequently left bundle branch block (39% vs. 28%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.027). The rate of primary prevention (68% vs. 59.6%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.058) and cardiac resynchronization therapy (27% vs. 19%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.02) were higher in women. After a median follow-up of 46 months (3382 patient-years), the incidence of both the primary combined endpoint of mortality\/transplant (20% vs. 29%; logrank\u2009=\u20090.031) and ICD therapies (27% vs. 34%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.138) were lower in women. According to the propensity score-matching analysis, no differences were observed between both sexes with respect to the incidence of mortality\/transplant (24.8% vs. 28.6%; logrank\u2009=\u20090.88), ICD therapies (28% vs. 27%; logrank\u2009=\u20090.17), and main cause of death (heart failure [HF]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The clinical characteristics at the moment of ICD implant are different between sexes. After adjusting them, both sexes equally benefit from the ICD. HF is the main cause of mortality both in men and women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jwh.2020.8475","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T12:23:37Z","timestamp":1605011017000},"page":"596-603","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Long-Term Survival After Implantable Cardiac Defibrillator Therapy According to Sex: A Propensity Matched Study"],"prefix":"10.1177","volume":"30","author":[{"given":"Eduardo","family":"Arana-Rueda","sequence":"first","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, Virgen del Roc\u00edo University Hospital, Sevilla, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"J\u00e1uregui","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, Virgen del Roc\u00edo University Hospital, Sevilla, Spain."},{"name":"Teknon Medical Center, Heart Institute, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Frutos-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, Virgen del Roc\u00edo University Hospital, Sevilla, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Acosta","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, Virgen del Roc\u00edo University Hospital, Sevilla, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Antonio","family":"S\u00e1nchez-Brotons","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, Virgen del Roc\u00edo University Hospital, Sevilla, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Garc\u00eda-Riesco","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, Virgen del Roc\u00edo University Hospital, Sevilla, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Campos-Pareja","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, Virgen del Roc\u00edo University Hospital, Sevilla, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Nieto","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, Virgen del Roc\u00edo University Hospital, Sevilla, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alonso","family":"Pedrote","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Department, Virgen del Roc\u00edo University Hospital, Sevilla, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22496"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euy067"},{"issue":"138","key":"e_1_3_3_4_2","first-page":"e210","article-title":"2017 AHA\/ACC\/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Executive summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"25","author":"Al-Khatib SM","year":"2018","unstructured":"Al-Khatib SM, , Stevenson WG, , Ackerman MJ, et al. 2017 AHA\/ACC\/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Executive summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. Circulation, 2018, 25; 138:e210\u2013e271.","journal-title":"Circulation"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043594"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.255"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2005.00224.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609758"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1608029"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2015.03.013"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14003"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux176"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12141"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv361"},{"key":"e_1_3_3_15_2","first-page":"1485","article-title":"Increasing sex differences in the use of cardiac resynchronization therapy with or without implantable cardioverter-defibrillator","volume":"38","author":"Chatterjee NA","year":"2017","unstructured":"Chatterjee NA, , Borgquist R, , Chang Y, et al. Increasing sex differences in the use of cardiac resynchronization therapy with or without implantable cardioverter-defibrillator. Eur Heart J, 2017; 38:1485\u20131494.","journal-title":"Eur Heart J"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv455"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu015"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1142"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1216"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000659"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux203"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.03.042"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002756"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-156-3-201202070-00007"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.05.146"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.037369"},{"key":"e_1_3_3_27_2","first-page":"800","article-title":"Biology, culture and society, factors configuring health from a gender perspective. 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