{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:34:09Z","timestamp":1783488849049,"version":"3.55.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Women's Health"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Quality of life in adenomyosis (AD) patients has been poorly investigated. Previous data suggest that AD has negative impact on the quality of life in these women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>From September 2018 to December 2019, all consecutive female premenopausal patients aged \u226518 years diagnosed with AD by transvaginal ultrasound (TVU) were invited to participate in a comparative cross-sectional study. The Short Form-36-item (SF-36) health questionnaire and the Hospital Anxiety and Depression Scale (HADS) were administered. Work productivity and activity impairment were assessed using the Work Productivity and Activity Impairment Questionnaire: General Health version (WPAI:GH). Data obtained from these patients were compared with women with normal-appearing myometrium in the TVU recruited during routine gynecological visits. The study was approved by the Clinical Research Ethics Committee of the Hospital Clinic (reference HCB\/2018\/0919).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      One hundred three patients with AD and 214 without AD were analyzed. Patients with AD compared to those without AD showed significantly lower scores in all domains of the SF-36 questionnaire and mean (SD) higher scores in the HADS questionnaire for anxiety (10.06 [3.04] vs. 6.92 [2.98],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and depression (6.39 [3.89] vs. 2.74 [2.01],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.002). Significant differences (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were also found for the percentages of absenteeism (12.2% vs. 1.1%), presenteeism (31.1% vs. 11.4%), overall work productivity loss (38.2% vs. 12.4%), and activity impairment (55.7% vs. 9.9%). The presence of AD was associated with higher yearly estimated indirect costs of \u20ac5161.32 (\u20ac7928.0 vs. \u20ac2460.8,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>AD negatively affects women's health-related quality of life, psychological health, and work productivity, with impairment at work and daily activities, and higher risk for anxiety and depression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/jwh.2020.8789","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T11:38:27Z","timestamp":1611056307000},"page":"1653-1659","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Impact of Adenomyosis on Women's Psychological Health and Work Productivity: A Comparative Cross-Sectional Study"],"prefix":"10.1177","volume":"30","author":[{"given":"Ana Mar\u00eda","family":"Alcalde","sequence":"first","affiliation":[{"name":"Gynecology Department, Institute Clinic of Gynecology, Obstetrics, and Neonatology, Hospital Clinic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"Mart\u00ednez-Zamora","sequence":"additional","affiliation":[{"name":"Gynecology Department, Institute Clinic of Gynecology, Obstetrics, and Neonatology, Hospital Clinic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meritxell","family":"Gracia","sequence":"additional","affiliation":[{"name":"Gynecology Department, Institute Clinic of Gynecology, Obstetrics, and Neonatology, Hospital Clinic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Ros","sequence":"additional","affiliation":[{"name":"Gynecology Department, Institute Clinic of Gynecology, Obstetrics, and Neonatology, Hospital Clinic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariona","family":"Rius","sequence":"additional","affiliation":[{"name":"Gynecology Department, Institute Clinic of Gynecology, Obstetrics, and Neonatology, Hospital Clinic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Nicol\u00e1s","sequence":"additional","affiliation":[{"name":"Gynecology Department, Institute Clinic of Gynecology, Obstetrics, and Neonatology, Hospital Clinic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Carmona","sequence":"additional","affiliation":[{"name":"Gynecology Department, Institute Clinic of Gynecology, Obstetrics, and Neonatology, Hospital Clinic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,11,12]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"20","article-title":"Long-term efficacy and quality of life with bilateral uterine artery occlusion plus partial resection of symptomatic adenomyosis","volume":"176","author":"Liu M","year":"2014","unstructured":"Liu M. 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